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Developmental Neurotoxicology

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Handbook Of Developmental Neurotoxicology

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Author : William Slikker, Jr.
language : en
Publisher: Academic Press
Release Date : 2018-01-04

Handbook Of Developmental Neurotoxicology written by William Slikker, Jr. and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-04 with Science categories.

Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition Contains new chapters that focus on subjects recent to the field Includes well-illustrated material, with diagrams, charts, and tables Contains compelling case studies and chapters written by world experts

Developmental Neurotoxicology

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Author : G Jean Harry
language : en
Publisher: CRC Press
Release Date : 1994-07-13

Developmental Neurotoxicology written by G Jean Harry and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-07-13 with Medical categories.

Developmental Neurotoxicology addresses a number of basic principles underlying the vulnerability of the developing nervous system to environmental toxicant exposure. Evidence of functional alterations, induced at levels of chemical exposure that fail to produce structural teratological alterations, indicates that the evaluation of the functional capacity of exposed animals may indeed offer a sensitive evaluation of developmental toxicity. The contributing authors discuss the basic principles of development in structure and functional components and present information covering various methodological approaches, as well as evidence for the value of examining the developing nervous system for environmentally induced perturbations. The final chapter covers how this type of data is used to evaluate human risk potential.

Developmental Neurotoxicology Research

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Author : Cheng Wang
language : en
Publisher: John Wiley & Sons
Release Date : 2011-04-12

Developmental Neurotoxicology Research written by Cheng Wang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-12 with Science categories.

This book describes how systems biology, pharmacogenomic and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. Authors review and discuss approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. This book presents cross-cutting research tools and animal models, along with applications to the studies associated with potential anesthetic-induced developmental neurotoxicity; the developmental basis of adolescent or adult onset of disease; risk assessment of methyl mercury and its effects on neurodevelopment; challenges in the field to identify environmental factors of relevance to autism; and the strategy and progress of epilepsy research.

Developmental Neurotoxicology

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Author : G Jean Harry
language : en
Publisher: CRC Press
Release Date : 1994-07-13

Human Developmental Neurotoxicology

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Author : David C. Bellinger
language : en
Publisher: CRC Press
Release Date : 2006-04-06

Human Developmental Neurotoxicology written by David C. Bellinger and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-06 with Medical categories.

This reference describes the most recent developments in the design, execution, and interpretation of human developmental neurotoxicology studies. Assessing critical issues and controversies in the field, this guide focuses on dose-response/effect relationships and explores challenges in the measurement of exposure to different types of chemicals, including selected metals, organic pollutants, pesticides, and recreational and therapeutic drugs.

Handbook Of Neurotoxicology

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Author : Edward J. Massaro
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-03-20

Handbook Of Neurotoxicology written by Edward J. Massaro and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-20 with Medical categories.

N eurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, 1ead, mercury, and the polytypic byproducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins ofbroadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentalIy by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor of some neurotoxicants of anthropogenic ori tunately, the environmental accumulation gin, expecialIy pesticides and metals, has resulted in incidents ofhuman poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the re suit of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxicants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.

International Review Of Research In Mental Retardation

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Author : Laraine Masters Glidden
language : en
Publisher: Gulf Professional Publishing
Release Date : 2005-12-09

International Review Of Research In Mental Retardation written by Laraine Masters Glidden and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-09 with Medical categories.

Neurotoxicity and Developmental Disabilities is a comprehensive review of the relationship between neurotoxicity and mental retardation. Though individual chapters each focus on a specific toxin, the chapters jointly emphasize that many variables influence the developmental outcomes following exposure to neurotoxicants, including timing of exposure, pattern of exposure, dose, susceptibility, and environmental conditions. Coverage includes the developmental consequences of maternal exposure to methyl mercury, and direct exposure to PCBs and Dioxins, lead, methanol, parental smoking, pthalates and pesticides. Additional chapters review research on environmental agents and autism, and assessment studies of exposure. This thematic volume in the International Review of Research in Mental Retardation begins with forewords by Stephen R. Schroeder, and series editor Laraine Glidden.

Neurotoxicology

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Author : Louis W. Chang
language : en
Publisher: Elsevier
Release Date : 1995-04-20

Neurotoxicology written by Louis W. Chang and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-04-20 with Science categories.

Neurotoxicology: Approaches and Methods provides a unique and comprehensive presentation of the current concepts and state-of-the-art methods for the assessment of neurotoxicity. The book analyzes various techniques available and discusses their strengths and weaknesses. This volume will serve as an excellent desk companion and laboratory guide for all investigators, researchers, clinicians, and students interested in neurotoxicology. The internationally knowngroup of editors divide the book into seven sections: Neuromorphological and Neuropathological Approaches; Neurophysiological Approaches; Neurobehavioral Toxicology; Neurochemical and Biomolecular Approaches; In-Vitro Models; Clinical Neurotoxicology; and Risk Assessment of Neurotoxicity. Each section yields the most up-to-date information by experts in their fields. Meticulously organized and edited, Neurotoxicology: Approaches and Methods is the most authoritative and well-planned neurotoxicology book on the market. Discusses neurobehavioral testing methods for assessment of neural dysfunctions Explains state-of-the-art diagnostic methods, such as clinico-neuropsychological and neurophysiological methods, for patients confronted by neurotoxic problems Discusses In Vitro methods, including aggregating brain cell methods, organotypic cultures, and the use of human neuronal cell lines for the assessment of neurotoxicity Presents step-by-step procedures for many methods Provides state-of-the-art neuromorphological and biomolecular methods and approaches for neurotoxicity investigation

In Vitro Neurotoxicology

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Author : Lucio G. Costa
language : en
Publisher: Humana Press
Release Date : 2011-08-09

In Vitro Neurotoxicology written by Lucio G. Costa and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-09 with Medical categories.

In recent years, the need to develop acceptable alternatives to conventional animal testing for neurotoxicity and developmental neurotoxicity has been increasingly recognized, and much effort is being directed toward the development of alternative models, utilizing mostly mammalian cells in culture but also non-mammalian model systems. In Vitro Neurotoxicology: Methods and Protocols presents a series of cellular, biochemical, and molecular methodological protocols in the area of in vitro neurotoxicology, with an emphasis on mammalian cell culture systems. Opening with a section on methodologies for preparing several cellular systems of variable complexity, amenable for in vitro neurotoxicological studies, the thorough volume continues with coverage of methods to measure cellular death and major mechanisms, methods for assessing mechanisms of nervous system cell toxicity related to impairment of cell signaling, while a final section illustrates additional methods for assessing important nervous system processes such as cell proliferation, neuritogenesis, and synaptogenesis. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, In Vitro Neurotoxicology: Methods and Protocols serves researchers with an interest in assessing or characterizing the potential neurotoxicity of environmental contaminants, drugs, or other chemicals.

Neurobehavioral Toxicity

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Author : Bernard Weiss
language : en
Publisher: CRC Press
Release Date : 1994-06-30

Neurobehavioral Toxicity written by Bernard Weiss and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-06-30 with Medical categories.

In establishing how certain chemicals can cause behavioural disorders, the process of neurotoxicity risk assessment poses significant challenges to every discipline within neuroscience. In this volume, leaders from industrial, academic, and government settings share insights on behavioural measurement in neurotoxicity risk assessment, and address the critical scientific issues arising from the expanding role of neurobehavioral toxicology in public policy development.; The authors set out to provide a comprehensive and authoritative review of current methods in the analysis and interpretation of neurobehavioural toxicology. Coverage begins with a discussion of criteria for determining neurotoxic potential. The next section examines neurobehavioural evaluations in developmental neurotoxicity. Subsequent sections focus on activity and observational data and applications of schedule-controlled operant behaviour in toxicity testing. The contributors address controversies surrounding the suitability and interpretation of procedures designed for neurotoxicological assessments. Some case studies are also included.

Developmental Neurotoxicology

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