Diabetic Cardiomyopathy
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Diabetic Cardiomyopathy
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Author : Belma Turan
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-01-08
Diabetic Cardiomyopathy written by Belma Turan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-08 with Science categories.
Diabetes has long been recognized as a disease of high blood sugar, and there has been a continuous search of the exact reason for its development and effective treatment. In 2005, the World Health Organization had estimated that more than 180 million people worldwide suffer from diabetes mellitus and indicated that this figure is likely to double within the next 20 years. Among the 3.8 million deaths each year associated with diabetes, about two thirds are attributable to cardiovascular complications, and diabetes is now considered to be a major metabolic risk factor for the occurrence of heart disease. Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms is a compilation of review articles devoted to the study on the topic with respect to biochemical and molecular mechanisms of hyperglycaemia. The wide range of areas covered here is of interest to basic research scientists, clinicians and graduate students, who are devoted to study the pathogenesis of diabetes-induced cardiovascular dysfunction. Furthermore, some chapters are directed towards increasing our understanding of novel ways for the prevention/treatment of cardiomyopathy. Twenty five articles in this book are organized in three sections. The first section discusses general aspects of the metabolic derangements in diabetic cardiomyopathy including metabolic alterations and substrate utilization as well as cardiac remodelling in the heart; role of diet in the development of metabolic syndrome in the heart; effect of hyperglycaemia in terms of biochemical and structural alterations in heart. In the second section, several cellular and molecular mechanisms are discussed indicating that diabetic cardiomyopathy is a multifactorial and complex problem. The third section discusses the prevention and treatment of diabetes using appropriate diet, proper supplements including antioxidants, angiotensin inhibitors and some other drugs. All in all, this book discusses the diverse mechanisms of diabetic cardiomyopathy with some information on new therapeutic approaches for finding solutions to prevent or reverse the development of cardiac dysfunction.
Diabetic Cardiomyopathy
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Author : Slavica Mitrovska
language : en
Publisher:
Release Date : 2020-04-14
Diabetic Cardiomyopathy written by Slavica Mitrovska and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-14 with categories.
Diabetic cardiomyopathy is defined as heart failure independent of the coronary artery, valve disease and hypertension. It has multifactorial aetiology but the pathogenesis is incompletely understood. Hyperglycemia, hyperlipidemia and inflammation with high oxidative stress lead to structural and functional alterations of the left ventricle (LV) and promote diabetic cardiomyopathy. Diastolic dysfunction is an early sign of diabetic cardiomyopathy. It has a long asymptomatic period, but with time leads to loss of contractile function. Hence, the identification of subclinical diabetic cardiomyopathy and correction of potentially modified risk factors are very important to delay the onset of heart failure. The aim: We aimed to assess the LV function in asymptomatic diabetic patients and its correlation with clinical and biochemical parameters. Study design: Cross-sectional study that includes a total number of 137 subjects. The target group consists of 72 asymptomatic normotensive patients with diabetes mellitus type 2, without coronary artery and valve disease. The control group is composed of 65 healthy subjects. Methods: All patients were subject to echocardiography (conventional 2D, M-mode, PW Doppler analysis and contemporary techniques-TDI and 2D-Speckle-Tracking Echocardiography). We evaluate LV diastolic and systolic function and its correlation with basic clinical characteristics (age, gender, BMI, BSA, waist to hip ratio, duration of diabetes) and biochemical analyses (glucose profile, lipid profile, CRP). The correlation between clinical, biochemical and echocardiographic parameters was assessed by the Pearson Product Moment of Correlation. A p-value of
Diabetes And Heart Failure Pathogenesis And Novel Therapeutic Approaches
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Author : Celestino Sardu
language : en
Publisher: Frontiers Media SA
Release Date : 2019-05-15
Diabetes And Heart Failure Pathogenesis And Novel Therapeutic Approaches written by Celestino Sardu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-15 with categories.
Understanding Molecular Mechanisms In Diabetic Cardiomyopathy Dcm
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Author : VijayaKumar Sukumaran
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-03
Understanding Molecular Mechanisms In Diabetic Cardiomyopathy Dcm written by VijayaKumar Sukumaran and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-03 with Medical categories.
Diabetes
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Author : Somasundaram Arumugam
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-10-29
Diabetes written by Somasundaram Arumugam and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-29 with Medical categories.
Diabetes mellitus (DM) is the most common metabolic disorder associated with high mortality, which is mostly due to its cardiovascular complications. Diabetic cardiomyopathy (CM) is characterized by abnormal ventricular function in the absence of DM-associated risk factors such as obesity, hypertension, hypercholesterolemia, or coronary artery disease. Oxidative stress plays a pivotal role in the development of diabetic CM, in which chronic hyperglycemia plays a major role. As this develops, the endogenous antioxidant system becomes suppressed and so cannot counter-balance the increased oxidative stress. The metabolic abnormalities of DM cause mitochondrial superoxide overproduction, which further enhances the production of other reactive species, including nitric oxide, hydroxyl radical, hydrogen peroxide and peroxy nitrite, causing aggravation of the myocardial damage. In addition, free-radical-mediated platelet activation in the narrowed arteries culminates in acute myocardial infarction and stroke, indirectly affecting cardiac function. This chapter focuses on various aspects of the oxidative stress induced by reactive species during the pathogenesis of diabetic CM.
The Heart In Diabetes
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Author : J.C. Chatham
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Heart In Diabetes written by J.C. Chatham and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Diabetes is a major public health problem which is expected to affect 160 million people worldwide by the year 2000. Clearly an understanding of the effects of diabetes on the heart is an important step in the development of strategies to reduce the incidence of heart disease for diabetic patients, thus increasing their overall life-expectancy and quality of life. In this book, the editors bring together the different lines of evidence supportive of the idea of a diabetic cardiomyopathy. The first chapter provides an overview of the impact of cardiac dysfunction on the mortality and morbidity of the diabetic population in general, as well as a presentation of clinical aspects of heart disease in diabetes. This is followed by chapters concerned with the pathological and functional changes that occur in the heart as a result of diabetes and a description of the various therapeutic interventions that are available to reverse the effects of diabetes on the heart. Subsequent chapters focus on changes in protein synthesis, membrane function and intermediary metabolism that take place following the onset of diabetes. Since these alterations precede many of the functional and pathological changes, it may be that the processes responsible for the functional decline and tissue injury are initiated by diabetes-induced changes at the cellular and/or biochemical level.
Medical Management Of Diabetes And Heart Disease
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Author : Burton E. Sobel
language : en
Publisher: CRC Press
Release Date : 2002-03-06
Medical Management Of Diabetes And Heart Disease written by Burton E. Sobel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-06 with Medical categories.
This state-of-the-art reference details current and effective symptom-specific strategies for the diagnosis and management of diabetic patients-emphasizing the exploration of therapeutic options available for the treatment of accelerated coronary complications associated with diabetes. Addresses the pathophysiology underlying advanced heart
Diabetes And Cardiovascular Disease
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Author : Aubie Angel
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Diabetes And Cardiovascular Disease written by Aubie Angel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Diabetes and cardiovascular disease together account for the largest portion of health care spending compared to all other diseases in Western society. This work seeks to provide an understanding of the causes of diabetes and its cardiovascular complications. As this understanding becomes more widely appreciated, it will serve as a foundation for evidence-based care and wider acceptance of sound science. The International Conference on Diabetes and Cardiovascular Disease, held in Winnipeg, in June 1999, was organized to bring together a multi-disciplinary group of researchers dedicated to further knowledge amongst researchers, care givers, and the managers of the health system. The invited speakers submitted their works for publication, which serves as the basis for this book. Major themes include: epidemiology of diabetes mellitus, metabolic risk factors in diabetes and cardiovascular disease, hypertension in diabetes mellitus, cardiac function in diabetes, glycemic control and improved cardiovascular function, diabetes management, and endothelial function in diabetes.
Heart Dysfunction In Diabetes
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Author : Grant N. Pierce
language : en
Publisher: CRC Press
Release Date : 2019-06-14
Heart Dysfunction In Diabetes written by Grant N. Pierce and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-14 with Medical categories.
Published in 1988: The enormous literature, scattered through journals devoted to physiology, biochemistry, pharmacology, ultrastructure, and clinical medicine, together with the laboratory observations of the authors, is reviewed and integrated in an effort to portray the origin, evolution, and consequences of heart dysfunction during diabetes.
The Diabetic Heart
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Author : Makoto Nagano
language : en
Publisher: New York : Raven Press
Release Date : 1991
The Diabetic Heart written by Makoto Nagano and has been published by New York : Raven Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.