Dna Microarray Technology And Data Analysis In Cancer Research

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Dna Microarray Technology And Data Analysis In Cancer Research

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Author : Shaoguang Li
language : en
Publisher: World Scientific
Release Date : 2009-02-04

Dna Microarray Technology And Data Analysis In Cancer Research written by Shaoguang Li and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-04 with Medical categories.

DNA microarray technology has become a useful technique in gene expression analysis for the development of new diagnostic tools and for the identification of disease genes and therapeutic targets for human cancers. Appropriate control for DNA microarray experiment and reliable analysis of the array data are key to performing the assay and utilizing the data correctly. The most difficult challenge has been the lack of a powerful method to analyze the data for all genes (more than 30,000 genes) simultaneously and to use the microarray data in a decision-making process. In this book, the authors describe DNA microarray technology and data analysis by pointing out current advantages and disadvantages of the technique and available analytical methods. Crucially, new ideas and analytical methods based on the authors' own experience in DNA microarray study and analysis are introduced. It is believed that this new way of interpreting and analyzing microarray data will bring us closer to success in decision-making using the information obtained through the DNA microarray technology.

High Dimensional Data Analysis In Cancer Research

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Author : Xiaochun Li
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-19

High Dimensional Data Analysis In Cancer Research written by Xiaochun Li and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-19 with Medical categories.

Multivariate analysis is a mainstay of statistical tools in the analysis of biomedical data. It concerns with associating data matrices of n rows by p columns, with rows representing samples (or patients) and columns attributes of samples, to some response variables, e.g., patients outcome. Classically, the sample size n is much larger than p, the number of variables. The properties of statistical models have been mostly discussed under the assumption of fixed p and infinite n. The advance of biological sciences and technologies has revolutionized the process of investigations of cancer. The biomedical data collection has become more automatic and more extensive. We are in the era of p as a large fraction of n, and even much larger than n. Take proteomics as an example. Although proteomic techniques have been researched and developed for many decades to identify proteins or peptides uniquely associated with a given disease state, until recently this has been mostly a laborious process, carried out one protein at a time. The advent of high throughput proteome-wide technologies such as liquid chromatography-tandem mass spectroscopy make it possible to generate proteomic signatures that facilitate rapid development of new strategies for proteomics-based detection of disease. This poses new challenges and calls for scalable solutions to the analysis of such high dimensional data. In this volume, we will present the systematic and analytical approaches and strategies from both biostatistics and bioinformatics to the analysis of correlated and high-dimensional data.

Feature Selection For High Dimensional Data

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Author : Verónica Bolón-Canedo
language : en
Publisher: Springer
Release Date : 2015-10-05

Feature Selection For High Dimensional Data written by Verónica Bolón-Canedo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-05 with Computers categories.

This book offers a coherent and comprehensive approach to feature subset selection in the scope of classification problems, explaining the foundations, real application problems and the challenges of feature selection for high-dimensional data. The authors first focus on the analysis and synthesis of feature selection algorithms, presenting a comprehensive review of basic concepts and experimental results of the most well-known algorithms. They then address different real scenarios with high-dimensional data, showing the use of feature selection algorithms in different contexts with different requirements and information: microarray data, intrusion detection, tear film lipid layer classification and cost-based features. The book then delves into the scenario of big dimension, paying attention to important problems under high-dimensional spaces, such as scalability, distributed processing and real-time processing, scenarios that open up new and interesting challenges for researchers. The book is useful for practitioners, researchers and graduate students in the areas of machine learning and data mining.

Cancer Diagnostics With Dna Microarrays

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Author : Steen Knudsen
language : en
Publisher: John Wiley & Sons
Release Date : 2006-11-03

Cancer Diagnostics With Dna Microarrays written by Steen Knudsen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-03 with Science categories.

Authored by an international authority in the field,Cancer Diagnostics with DNA Microarrays is a complete reference work on the rapidly growing use of DNA microarray data in the diagnosis of and treatment planning for a large number of human cancers. Uniquely deals with direct clinical application of microarray data to oncology diagnosis, leading to more effective diagnosis of and clearer treatment regimens for a wide range of human cancers Offers clinicians summary presentation of state-of-the-art science of DNA microarrays Each chapter includes bibliographic and further reading suggestions Easily accessible, assuming no special training in statistics or bioinformatics Replete with examples and mini-cases, Cancer Diagnostics with DNA Microarrays offers cancer researchers in private, pharmacologic, and governmental institutions, biomedical statisticians, and practicing oncologists concise, thoughtfully authored guidance on the use of microarray data and analysis as clinical tools. The text carefully addresses the needs of end users – researchers and physicians – using microarrays as a tool to be applied in common clinical situations, and is of interest for students in medicine and biology and professionals in health care as well.

Recent Developments In Machine Learning And Data Analytics

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Author : Jugal Kalita
language : en
Publisher: Springer
Release Date : 2018-09-11

Recent Developments In Machine Learning And Data Analytics written by Jugal Kalita and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-11 with Computers categories.

This book presents high-quality papers from an international forum for research on computational approaches to learning. It includes current research and findings from various research labs, universities and institutions that may lead to development of marketable products. It also provides solid support for these findings in the form of empirical studies, theoretical analysis, or comparison to psychological phenomena. Further, it features work that shows how to apply learning methods to solve important application problems as well as how machine learning research is conducted. The book is divided into two main parts: Machine Learning Techniques, which covers machine learning-related research and findings; and, Data Analytics, which introduces recent developments in this domain. Additionally, the book includes work on data analytics using machine learning techniques.

Microarray Image And Data Analysis

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Author : Luis Rueda
language : en
Publisher: CRC Press
Release Date : 2018-09-03

Microarray Image And Data Analysis written by Luis Rueda and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with Science categories.

Microarray Image and Data Analysis: Theory and Practice is a compilation of the latest and greatest microarray image and data analysis methods from the multidisciplinary international research community. Delivering a detailed discussion of the biological aspects and applications of microarrays, the book: Describes the key stages of image processing, gridding, segmentation, compression, quantification, and normalization Features cutting-edge approaches to clustering, biclustering, and the reconstruction of regulatory networks Covers different types of microarrays such as DNA, protein, tissue, and low- and high-density oligonucleotide arrays Examines the current state of various microarray technologies, including their availability and affordability Explains how data generated by microarray experiments are analyzed to obtain meaningful biological conclusions An essential reference for academia and industry, Microarray Image and Data Analysis: Theory and Practice provides readers with valuable tools and techniques that extend to a wide range of biological studies and microarray platforms.

Journal Of The National Cancer Institute

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Author :
language : en
Publisher:
Release Date : 2007

Journal Of The National Cancer Institute written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Cancer categories.

Each issue is packed with extensive news about important cancer related science, policy, politics and people. Plus, there are editorials and reviews by experts in the field, book reviews, and commentary on timely topics.

Biochemistry And Molecular Biology Compendium

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Author : Roger L. Lundblad
language : en
Publisher: CRC Press
Release Date : 2019-11-11

Biochemistry And Molecular Biology Compendium written by Roger L. Lundblad and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-11 with Medical categories.

This book is an accessible resource offering practical information not found in more database-oriented resources. The first chapter lists acronyms with definitions, and a glossary of terms and subjects used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. There follows chapters on chemicals employed in biochemistry and molecular biology, complete with properties and structure drawings. Researchers will find this book to be a valuable tool that will save them time, as well as provide essential links to the roots of their science. Key selling features: Contains an extensive list of commonly used acronyms with definitions Offers a highly readable glossary for systems and techniques Provides comprehensive information for the validation of biotechnology assays and manufacturing processes Includes a list of Log P values, water solubility, and molecular weight for selected chemicals Gives a detailed listing of protease inhibitors and cocktails, as well as a list of buffers

Research And Applications In Global Supercomputing

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Author : Segall, Richard S.
language : en
Publisher: IGI Global
Release Date : 2015-01-31

Research And Applications In Global Supercomputing written by Segall, Richard S. and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-31 with Computers categories.

Rapidly generating and processing large amounts of data, supercomputers are currently at the leading edge of computing technologies. Supercomputers are employed in many different fields, establishing them as an integral part of the computational sciences. Research and Applications in Global Supercomputing investigates current and emerging research in the field, as well as the application of this technology to a variety of areas. Highlighting a broad range of concepts, this publication is a comprehensive reference source for professionals, researchers, students, and practitioners interested in the various topics pertaining to supercomputing and how this technology can be applied to solve problems in a multitude of disciplines.

Analyzing Microarray Gene Expression Data

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Author : Geoffrey J. McLachlan
language : en
Publisher: John Wiley & Sons
Release Date : 2005-02-18

Analyzing Microarray Gene Expression Data written by Geoffrey J. McLachlan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-02-18 with Mathematics categories.

A multi-discipline, hands-on guide to microarray analysis of biological processes Analyzing Microarray Gene Expression Data provides a comprehensive review of available methodologies for the analysis of data derived from the latest DNA microarray technologies. Designed for biostatisticians entering the field of microarray analysis as well as biologists seeking to more effectively analyze their own experimental data, the text features a unique interdisciplinary approach and a combined academic and practical perspective that offers readers the most complete and applied coverage of the subject matter to date. Following a basic overview of the biological and technical principles behind microarray experimentation, the text provides a look at some of the most effective tools and procedures for achieving optimum reliability and reproducibility of research results, including: An in-depth account of the detection of genes that are differentially expressed across a number of classes of tissues Extensive coverage of both cluster analysis and discriminant analysis of microarray data and the growing applications of both methodologies A model-based approach to cluster analysis, with emphasis on the use of the EMMIX-GENE procedure for the clustering of tissue samples The latest data cleaning and normalization procedures The uses of microarray expression data for providing important prognostic information on the outcome of disease