Dna Microarrays And Gene Expression
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Dna Microarrays And Gene Expression
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Author : Pierre Baldi
language : en
Publisher:
Release Date : 2002
Dna Microarrays And Gene Expression written by Pierre Baldi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with DNA microarrays categories.
DNA microarrays are revolutionizing biology and medicine. They can provide a snapshot of the level of gene expression in a cell and are therefore a powerful tool with which to study biological phenomena at the molecular level. This inter-disciplinary introduction will be essential reading for researchers of all disciplines.
Design And Analysis Of Dna Microarray Investigations
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Author : Richard M. Simon
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-05-09
Design And Analysis Of Dna Microarray Investigations written by Richard M. Simon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-09 with Medical categories.
DNA microarrays are an important technology for studying gene expression. With a single hybridization, the level of expression of thousands of genes, or even an entire genome, can be estimated for a sample of cells. Consequently, manylaboratoriesareattemptingtoutilizeDNAmicroarraysintheirresearch. Whereaslaboratoriesarewellpreparedtoaddressthesigni?cantexperimental challenges in obtaining reproducible data from this RNA-based assay, inv- tigators are less prepared to analyze the large volumes of data produced by DNA microarrays. Although many software packages have been developed for the analysis of DNA microarray data, software alone is insu?cient. One needs knowledge aboutthevariousaspectsofdataanalysisinordertoselectandutilizesoftware e?ectively. There is a plethora of analysis methods being published and it is di?cult for biologists to determine which methods are valid and appropriate for their problems. Many scientists have learned that software is not an adequate substitute for biostatistical knowledge and seek statistical collaborators. Unfortunately, there is presently a shortage of statisticians who are available and knowled- able about DNA microarrays. For statisticians to be e?ective collaborators in anyarea,theymustinvestthetimetounderstandthesubjectmatterareaand become familiar with the literature so that they can ask the right questions and identify the key issues. Our objectives in this book are twofold: to provide scientists with infor- tion about the design and analysis of studies using DNA microarrays that will enable them to plan and analyze their own studies or to work with statistical collaborators e?ectively, and to aid statistical and computational scientists wishing to develop expertise in this area.
Dna Microarrays And Gene Expression
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Author : Pierre Baldi
language : en
Publisher: Cambridge University Press
Release Date : 2011-04-28
Dna Microarrays And Gene Expression written by Pierre Baldi and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. Originally published in 2002, this inter-disciplinary introduction to DNA arrays will be of value to anyone with an a interest in this powerful technology.
Dna Microarrays
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Author : Mark Schena
language : en
Publisher: Practical Approach Series
Release Date : 1999
Dna Microarrays written by Mark Schena and has been published by Practical Approach Series this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
DNA microarrays, or biochips, are small glass chips embedded with ordered rows of DNA and by providing a massive parallel platform for data gathering represent a fundamental technical advance in biomedical research. Such biochips enable the use of advanced fabrication, detection, and data mining technologies that allow data gathering at an unprecedented rate. The first chapter is an introduction to the technology of DNA microarrays, emphasizing the methodological fundamentals of biochips. The next two chapters describe the use of confocal scanning in microarray detection and techniques for the efficient cloning and screening of differentially expressed genes. Chapter 4 describes assay optimization for enzymatic assays and chapter 5 antisense scanning arrays. This is followed by a chapter on the manufacture of molecular arrays using ink-jet printing technology. Chapter 7 describes gene expression analysis from cDNA microarrays and then chapter 8 covers the use of expression data in bioinformatics. Chapter 9 describes the use of active microelectronic arrays for DNA hybridization analysis and the last chapter details the use of microarray technology in pharmacogenomics. This Practical Approach book is a comprehensive overview of the new and expanding field of DNA microarray technology and will be invaluable to any researcher interested in the use of biochips.
Dna Microarrays And Gene Expression
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Author : Pierre Baldi
language : en
Publisher: Cambridge University Press
Release Date : 2011-04-28
Dna Microarrays And Gene Expression written by Pierre Baldi and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
Massive data acquisition technologies--such as genome sequencing, high-throughput drug screening, and DNA arrays--are in the process of revolutionizing biology and medicine. This concise, user-friendly and interdisciplinary guide to DNA microarray technology is an introduction and a reference for both biologists and computational scientists. The authors describe the underlying technologies and offer an awareness of the "noise" and pitfalls present in the data generated. They also provide an idea of the different data mining techniques and algorithms that are available to interpret data, and the advantages and disadvantages of each in differing situations.
Dna Microarrays
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Author : Bertrand Jordan
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-08-28
Dna Microarrays written by Bertrand Jordan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-08-28 with Medical categories.
DNA Arrays for expression measurement: an historical perspective. (Bertrand R. Jordan). Expression profiling with cDNA microarrays: a user's perspective and guide. (Sean Grimmond and Andy Greenfield). cDNA microarrays on nylon membranes with enzyme colorimetric detection. (Konan Peck and Yuh-Pyng Sher). cDNA macroarrays and microarrays on nylon membranes with radioactive detection. (Beatrice Loriod, Geneviève Victorero and Catherine Nguyen). Oligonucleotide chips for expression analysis: principles and practical procedures. (Pierre Casellas, Annick Peleraux and Sylvaine Galiegue). Gene expression Data mining and analysis (Alvis Brazma, Alan Robinson and Jaak Vilo). Future trends in the use of DNA arrays for expression measurement. (Bertrand R. Jordan).
Microarray Gene Expression Data Analysis
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Author : Helen Causton
language : en
Publisher: John Wiley & Sons
Release Date : 2009-04-01
Microarray Gene Expression Data Analysis written by Helen Causton and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-01 with Science categories.
This guide covers aspects of designing microarray experiments and analysing the data generated, including information on some of the tools that are available from non-commercial sources. Concepts and principles underpinning gene expression analysis are emphasised and wherever possible, the mathematics has been simplified. The guide is intended for use by graduates and researchers in bioinformatics and the life sciences and is also suitable for statisticians who are interested in the approaches currently used to study gene expression. Microarrays are an automated way of carrying out thousands of experiments at once, and allows scientists to obtain huge amounts of information very quickly Short, concise text on this difficult topic area Clear illustrations throughout Written by well-known teachers in the subject Provides insight into how to analyse the data produced from microarrays
Dna Arrays
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Author : Jang B. Rampal
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-03-16
Dna Arrays written by Jang B. Rampal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-03-16 with Medical categories.
Annotation Researchers, engineers, and technologists explain in detail how to design and construct DNA microarrays, as well as how to hybridize them with biological samples for analysis. They offer step-by-step instructions for attaching and printing arrays on various matrices, and for biological sample preparation, hybridization conditions, signal detection, probe optimization, different printing technologies, and data collection and analysis (bioinformatics). Additional topics covered include genotyping, sequencing by hybridization, and HLA-DQA typing techniques. For biological and biomedical researchers. Rampal works in the private sector. Annotation c. Book News, Inc., Portland, OR (booknews.com).
Analyzing Microarray Gene Expression Data
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Author : Geoffrey J. McLachlan
language : en
Publisher: John Wiley & Sons
Release Date : 2005-02-18
Analyzing Microarray Gene Expression Data written by Geoffrey J. McLachlan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-02-18 with Mathematics categories.
A multi-discipline, hands-on guide to microarray analysis of biological processes Analyzing Microarray Gene Expression Data provides a comprehensive review of available methodologies for the analysis of data derived from the latest DNA microarray technologies. Designed for biostatisticians entering the field of microarray analysis as well as biologists seeking to more effectively analyze their own experimental data, the text features a unique interdisciplinary approach and a combined academic and practical perspective that offers readers the most complete and applied coverage of the subject matter to date. Following a basic overview of the biological and technical principles behind microarray experimentation, the text provides a look at some of the most effective tools and procedures for achieving optimum reliability and reproducibility of research results, including: An in-depth account of the detection of genes that are differentially expressed across a number of classes of tissues Extensive coverage of both cluster analysis and discriminant analysis of microarray data and the growing applications of both methodologies A model-based approach to cluster analysis, with emphasis on the use of the EMMIX-GENE procedure for the clustering of tissue samples The latest data cleaning and normalization procedures The uses of microarray expression data for providing important prognostic information on the outcome of disease
Advanced Analysis Of Gene Expression Microarray Data
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Author : Aidong Zhang
language : en
Publisher: World Scientific
Release Date : 2006
Advanced Analysis Of Gene Expression Microarray Data written by Aidong Zhang and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Science categories.
Focuses on the development and application of the latest advanced data mining, machine learning, and visualization techniques for the identification of interesting, significant, and novel patterns in gene expression microarray data. Describes cutting-edge methods for analyzing gene expression microarray data. Coverage includes gene-based analysis, sample-based analysis, pattern-based analysis and visualization tools.