Dna Arrays
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Dna Microarrays
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Author : Mark Schena
language : en
Publisher: Practical Approach Series
Release Date : 1999
Dna Microarrays written by Mark Schena and has been published by Practical Approach Series this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
DNA microarrays, or biochips, are small glass chips embedded with ordered rows of DNA and by providing a massive parallel platform for data gathering represent a fundamental technical advance in biomedical research. Such biochips enable the use of advanced fabrication, detection, and data mining technologies that allow data gathering at an unprecedented rate. The first chapter is an introduction to the technology of DNA microarrays, emphasizing the methodological fundamentals of biochips. The next two chapters describe the use of confocal scanning in microarray detection and techniques for the efficient cloning and screening of differentially expressed genes. Chapter 4 describes assay optimization for enzymatic assays and chapter 5 antisense scanning arrays. This is followed by a chapter on the manufacture of molecular arrays using ink-jet printing technology. Chapter 7 describes gene expression analysis from cDNA microarrays and then chapter 8 covers the use of expression data in bioinformatics. Chapter 9 describes the use of active microelectronic arrays for DNA hybridization analysis and the last chapter details the use of microarray technology in pharmacogenomics. This Practical Approach book is a comprehensive overview of the new and expanding field of DNA microarray technology and will be invaluable to any researcher interested in the use of biochips.
Dna Microarrays And Gene Expression
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Author : Pierre Baldi
language : en
Publisher: Cambridge University Press
Release Date : 2011-04-28
Dna Microarrays And Gene Expression written by Pierre Baldi and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. Originally published in 2002, this inter-disciplinary introduction to DNA arrays will be of value to anyone with an a interest in this powerful technology.
Dna Arrays
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Author : Jang B. Rampal
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Dna Arrays written by Jang B. Rampal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
Microarray technology provides a highly sensitive and precise te- nique for obtaining information from biological samples, with the added advantage that it can handle a large number of samples simultaneously that may be analyzed rapidly. Researchers are applying microarray technology to understand gene expression, mutation analysis, and the sequencing of genes. Although this technology has been experimental, and thus has been through feasibility studies, it has just recently entered into widespread use for advanced research. The purpose of DNA Arrays: Methods and Protocols is to provide instruction in designing and constructing DNA arrays, as well as hybridizing them with biological samples for analysis. An additional purpose is to p- vide the reader with a broad description of DNA-based array technology and its potential applications. This volume also covers the history of DNA arrays—from their conception to their ready off-the-shelf availability—for readers who are new to array technology as well as those who are well versed in this field. Stepwise, detailed experimental procedures are described for constructing DNA arrays, including the choice of solid support, attachment methods, and the general conditions for hybridization. With microarray technology, ordered arrays of oligonucleotides or other DNA sequences are attached or printed to the solid support using au- mated methods for array synthesis. Probe sequences are selected in such a way that they have the appropriate sequence length, site of mutation, and T .
Dna Microarrays
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Author : David Bowtell
language : en
Publisher:
Release Date : 2003
Dna Microarrays written by David Bowtell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
DNA microarray technology is a new and powerful means to analyze genomes and characterize patterns of gene expression. Its applications are widespread across the many fields of plant and animal biological and biomedical research. This manual, designed to extend and to complement the information in the best–selling Molecular Cloning,is a synthesis of the expertise and experience of more than 30 contributors—all innovators in a fast–moving field. DNA Microarraysprovides authoritative, detailed instruction on the design, construction, and applications of microarrays, as well as comprehensive descriptions of the software tools and strategies required for analysis of images and data.
Dna Methylation Microarrays
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Author : Sun-Chong Wang
language : en
Publisher: CRC Press
Release Date : 2008-04-24
Dna Methylation Microarrays written by Sun-Chong Wang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-24 with Mathematics categories.
Providing an interface between dry-bench bioinformaticians and wet-lab biologists, DNA Methylation Microarrays: Experimental Design and Statistical Analysis presents the statistical methods and tools to analyze high-throughput epigenomic data, in particular, DNA methylation microarray data. Since these microarrays share the same under
Dna Microarrays Part A Array Platforms And Wet Bench Protocols
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Author :
language : en
Publisher: Elsevier
Release Date : 2011-08-19
Dna Microarrays Part A Array Platforms And Wet Bench Protocols written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-19 with Science categories.
Modern DNA microarray technologies have evolved over the past 25 years to the point where it is now possible to take many million measurements from a single experiment. These two volumes, Parts A & B in the Methods in Enzymology series provide methods that will shepard any molecular biologist through the process of planning, performing, and publishing microarray results. Part A starts with an overview of a number of microarray platforms, both commercial and academically produced and includes wet bench protocols for performing traditional expression analysis and derivative techniques such as detection of transcription factor occupancy and chromatin status. Wet-bench protocols and troubleshooting techniques continue into Part B. These techniques are well rooted in traditional molecular biology and while they require traditional care, a researcher that can reproducibly generate beautiful Northern or Southern blots should have no difficulty generating beautiful array hybridizations. Data management is a more recent problem for most biologists. The bulk of Part B provides a range of techniques for data handling. This includes critical issues, from normalization within and between arrays, to uploading your results to the public repositories for array data, and how to integrate data from multiple sources. There are chapters in Part B for both the debutant and the expert bioinformatician. - Provides an overview of platforms - Includes experimental design and wet bench protocols - Presents statistical and data analysis methods, array databases, data visualization and meta-analysis
Dna Microarrays And Gene Expression
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Author : Pierre Baldi
language : en
Publisher: Cambridge University Press
Release Date : 2011-04-28
Dna Microarrays And Gene Expression written by Pierre Baldi and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
Massive data acquisition technologies--such as genome sequencing, high-throughput drug screening, and DNA arrays--are in the process of revolutionizing biology and medicine. This concise, user-friendly and interdisciplinary guide to DNA microarray technology is an introduction and a reference for both biologists and computational scientists. The authors describe the underlying technologies and offer an awareness of the "noise" and pitfalls present in the data generated. They also provide an idea of the different data mining techniques and algorithms that are available to interpret data, and the advantages and disadvantages of each in differing situations.
Microarray Technology Through Applications
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Author : Francesco Falciani
language : en
Publisher: Garland Science
Release Date : 2007-06-30
Microarray Technology Through Applications written by Francesco Falciani and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-30 with Science categories.
Microarray Technology Through Applications provides the reader with an understanding, from an applications perspective, of the diverse range of concepts required to master the experimental and data analysis aspects of microarray technology. The first chapter is a concise introduction to the technology and provides the theoretical background required to understand the subsequent sections. The following chapters are a series of case studies representative of the most general and important applications of microarray technology, including CGH, analysis of gene expression, SNP arrays and protein arrays. The case studies are written by experts in the field and describe prototypic projects, indicating how to generalize the approach to similar studies. There are detailed step-by-step protocols describing the specific experimental and data analysis protocols mentioned in the case study section. There is also information on printing glass DNA microarray slides and data interpretation. Colour figures and data sets are provided on the website at http://www.garlandscience.com/9780415378536
Microarrays
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Author : Jang B. Rampal
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-07-27
Microarrays written by Jang B. Rampal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-27 with Medical categories.
Microarray Technology, Volumes 1 and 2, present information in designing and fabricating arrays and binding studies with biological analytes while providing the reader with a broad description of microarray technology tools and their potential applications. The first volume deals with methods and protocols for the preparation of microarrays. The second volume details applications and data analysis, which is important in analyzing the enormous data coming out of microarray experiments. Among the topics discussed in Volume 1: Synthesis Methods, are matrices in the synthesis of microarrays, array optimization processes, array-based comparative genomic hybridization, 60-mer oligonucleotide probes, bifunctional reagents NTMTA and NTPAC, and high density arrays using digital microarray synthesis platforms. Other topics include multiplex ligation-dependent probe amplification (MLPA), hybridization conditions in situ-synthesized oligo arrays, peptide arrays, high density replication tools (HDRT), protocols for the quantification of oligo hybridization, glyco-bead arrays, and an investigation into the emerging nano technology. Microarray Technology, Volumes 1 and 2, provide ample information to all levels of scientists from novice to those intimately familiar with array technology.
Dna Microarrays Part B Databases And Statistics
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Author :
language : en
Publisher: Elsevier
Release Date : 2006-08-28
Dna Microarrays Part B Databases And Statistics written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-28 with Science categories.
Modern DNA microarray technologies have evolved over the past 25 years to the point where it is now possible to take many million measurements from a single experiment. These two volumes, Parts A & B in the Methods in Enzymology series provide methods that will shepard any molecular biologist through the process of planning, performing, and publishing microarray results. Part A starts with an overview of a number of microarray platforms, both commercial and academically produced and includes wet bench protocols for performing traditional expression analysis and derivative techniques such as detection of transcription factor occupancy and chromatin status. Wet-bench protocols and troubleshooting techniques continue into Part B. These techniques are well rooted in traditional molecular biology and while they require traditional care, a researcher that can reproducibly generate beautiful Northern or Southern blots should have no difficulty generating beautiful array hybridizations. Data management is a more recent problem for most biologists. The bulk of Part B provides a range of techniques for data handling. This includes critical issues, from normalization within and between arrays, to uploading your results to the public repositories for array data, and how to integrate data from multiple sources. There are chapters in Part B for both the debutant and the expert bioinformatician. - Provides an overview of platforms - Includes experimental design and wet bench protocols - Presents statistical and data analysis methods, array databases, data visualization and meta analysis