Dna Methylation Microarrays
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Dna Methylation Microarrays
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Author : Sun-Chong Wang
language : en
Publisher: CRC Press
Release Date : 2008-04-24
Dna Methylation Microarrays written by Sun-Chong Wang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-24 with Mathematics categories.
Providing an interface between dry-bench bioinformaticians and wet-lab biologists, DNA Methylation Microarrays: Experimental Design and Statistical Analysis presents the statistical methods and tools to analyze high-throughput epigenomic data, in particular, DNA methylation microarray data. Since these microarrays share the same under
Microarrays In Inflammation
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Author : Andreas Bosio
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-05-14
Microarrays In Inflammation written by Andreas Bosio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-14 with Medical categories.
This book summarizes the most advanced technical aspects covering all steps for a thorough application of microarrays to inflammation topics – from sample generation to data analysis. In addition selected examples of successful applications of microarrays in major fields of inflammation research are presented. The book will help a researcher or clinician to plan, perform and analyze or to critically review microarray experiments related to inflammation research.
Microarray Innovations
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Author : Gary Hardiman
language : en
Publisher: CRC Press
Release Date : 2009-04-02
Microarray Innovations written by Gary Hardiman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-02 with Medical categories.
In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarr
Dna Methylation
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Author : Jörg Tost
language : en
Publisher: Humana Press
Release Date : 2010-12-01
Dna Methylation written by Jörg Tost and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-01 with Medical categories.
Over the past few years, DNA methylation technologies and our knowledge of DNA methylation patterns have been advancing at a breathtaking pace. Due to this fact, DNA Methylation: Methods and Protocols, Second Edition completely revises, updates, and expands upon the popular first edition with the most current novel techniques, easier to use and more refined by the tested experience of leading experts. This revision reflects contemporary study of the subject: the analysis of gene-specific DNA methylation patterns has been complemented by genome-wide approaches, and epigenomics takes a central place. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters in this volume present brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, DNA Methylation: Methods and Protocols, Second Edition is the perfect resource for scientists who wish to further our understanding of the molecular processes that determine the genomic DNA methylation landscape and for those who aim to identify and implement DNA methylation-based biomarkers for clinical and diagnostic applications.
Principles Of Nutrigenetics And Nutrigenomics
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Author : Raffaele De Caterina
language : en
Publisher: Academic Press
Release Date : 2019-09-22
Principles Of Nutrigenetics And Nutrigenomics written by Raffaele De Caterina and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-22 with Medical categories.
Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields. - Uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics - Includes a valuable guide to ethics for genetic testing for nutritional advice - Chapters include definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts - Companion website includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book
The Use Of Genome Wide Dna Methylation Microarray To Study Both The Common And Rare Diseases
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Author : 楊傑燊
language : en
Publisher:
Release Date : 2014
The Use Of Genome Wide Dna Methylation Microarray To Study Both The Common And Rare Diseases written by 楊傑燊 and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with DNA categories.
Molecular Genetics And Emerging Therapies For Epithelial Ovarian Cancer Basic Research And Clinical Perspectives
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Author : Stergios Boussios
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-06
Molecular Genetics And Emerging Therapies For Epithelial Ovarian Cancer Basic Research And Clinical Perspectives written by Stergios Boussios and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-06 with Medical categories.
Epithelial ovarian cancer (EOC) is the most lethal gynecological disorder due to a lack of effective early detection strategies. Worldwide, approximately 230,000 women are diagnosed annually, whereas 150,000 die. It represents the seventh most commonly diagnosed cancer among women in the world with 5-year survival rate of 46%. More than one-fifth of EOC have been related to hereditary conditions. Considerable efforts have been made to implement screening of the general population to diagnose EOC early; nevertheless, this has been ineffective and there is no approved strategy. Nowadays, new approaches for early diagnosis and prevention based on molecular genomics are in development. Whole genome sequencing has established the potency of the somatic genome, characterised with diverse DNA repair deficiencies that can be used to stratify EOCs into distinct biological groups with predictive signatures of resistance or relapse. The incorporation of next-generation sequencing (NGS) into clinical practice remains challenging for two reasons. Firstly, the EOC risk is not clear for some of the included genes and secondly, the variant of uncertain significance rates increase as more genes are analyzed. Finally, beyond germline pathogenic variants, somatic mutations may also affect therapeutic choices, and as such upfront tumor sequencing may be equally important to NGS, particularly as we continue to challenge treatment paradigms in the first‐line management of EOC.
The Use Of Genome Wide Dna Methylation Microarray To Study Both The Common And Rare Diseases
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Author : Kit-San Yeung
language : en
Publisher:
Release Date : 2017-01-26
The Use Of Genome Wide Dna Methylation Microarray To Study Both The Common And Rare Diseases written by Kit-San Yeung and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-26 with categories.
This dissertation, "The Use of Genome-wide DNA Methylation Microarray to Study Both the Common and Rare Diseases" by Kit-san, Yeung, 楊傑燊, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: DNA methylation plays many important roles in human physiology such as imprinting and X chromosome inactivation (XCI), and therefore disruption in DNA methylation can lead to disease development. The objective of this study is to study the role of DNA methylation in both the common and rare disease, using Systemic Lupus Erythematosus (SLE) and chromosome X translocation as the example respectively. The genome-wide DNA methylation analysis was studied by Illumina HumanMethylation450 BeadChip, which is the microarray that allows the detection of more than 480,000 CpG sites across 99% of reference sequence genes. Numerous studies have shown that hypomethylation occurred in specific genes of SLE patients, and genome-wide DNA methylation analysis has never been performed in Chinese before. Since DNA methylation can be ethnicity-specific, we aim to identify the Chinese-specific DNA methylation pattern in SLE patients. Microarray results showed that differential DNA methylation changes were loci-specific, where 36 CpG sites showed loss of DNA methylation while 8 of them showed gain of it, representing 24 genes and 7 genes respectively. In order to replicate the microarray findings, bisulfite pyrosequencing was performed in an additional cohort of 100 patients and 100 controls on four hypomethylated genes, which were selected based on their relevance with immunity. Bisulfite pyrosequencing confirmed the microarray result that hypomethylation occurred in SLE, and were associated with increased in the corresponding gene's mRNA expressions. Gene ontology analysis revealed that hypomethylated genes identified in the microarray study were overrepresented in type I interferon pathway, where type I interferon has long been implicated in SLE pathogenesis. Therefore this study also support the importance of type I interferon in SLE from the epigenetic point of view. X;autosome translocation is a rare condition and the autosome with chromosome X translocated on can be inactivated by XCI, but DNA methylation change is rarely used to investigate the spread of XCI. In this study, we aim to identify genes subjected to XCI in X;15 translocation using the DNA methylation microarray. Results of microarray showed that 586 CpG sites spanning the long arm of chromosome 15 had DNA methylation gain of more than 20%. Since genes subjected to XCI are known to have gain of DNA methylation in their corresponding CpG-island promoters, the analysis was then focused on CpG sites in these regions, and a total of 75 sites representing 24 genes were hypermethylated. Nearly all of these CpG sites are located in region proximal to the breakpoint, from 15q11.2 to 15q21.3 accounting for 35Mb, suggesting that XCI was spread to the proximal region of 15q. Gain of DNA methylation, especially in the CpG-island promoter, can result in functional inactivation of genes, and therefore could explain the worsen phenotype of the patient. In conclusion, we successfully demonstrated the use of genome-wide DNA methylation microarray in different diseases, allowing the identification of genes or pathways important in diseases and opened the door for further investigation of the effect of these differentially methylated genes on disease. DOI: 10.5353/th_b5334844 Subjects: DNA - Methylation Medical genetics
Role Of Epigenetic Regulators In The Initiation Progression And Metastasis Of Cancer
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Author : Ritu Kulshreshtha
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-30
Role Of Epigenetic Regulators In The Initiation Progression And Metastasis Of Cancer written by Ritu Kulshreshtha and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-30 with Science categories.
Molecular Exercise Physiology
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Author : Adam P Sharples
language : en
Publisher: Routledge
Release Date : 2022-05-11
Molecular Exercise Physiology written by Adam P Sharples and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-11 with Science categories.
Fully revised and expanded, the second edition of Molecular Exercise Physiology offers a student-friendly introduction. It introduces a history documenting the emergence of molecular biology techniques to investigate exercise physiology, the methodology used, exercise genetics and epigenetics, and the molecular mechanisms that lead to adaptation after different types of exercise, with explicit links to outcomes in sport performance, nutrition, physical activity and clinical exercise. Structured around key topics in sport and exercise science and featuring contributions from pioneering scientists, such as Nobel Prize winners, this edition includes new chapters based on cutting-edge research in epigenetics and muscle memory, satellite cells, exercise in cancer, at altitude, and in hot and cold climates. Chapters include learning objectives, structured guides to further reading, review questions, overviews of work by key researchers and box discussions from important pioneers in the field, making it a complete resource for any molecular exercise physiology course. The book includes cell and molecular biology laboratory methods for dissertation and research projects in molecular exercise physiology and muscle physiology. This book is essential reading for upper-level undergraduate or postgraduate courses in cellular and molecular exercise physiology and muscle physiology. It is a valuable resource for any student with an advanced interest in exercise physiology in both sport performance and clinical settings.