Dna Modifications In The Brain
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Dna Modifications In The Brain
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Author : Timothy W Bredy
language : en
Publisher: Academic Press
Release Date : 2016-12-23
Dna Modifications In The Brain written by Timothy W Bredy and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-23 with Science categories.
DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease. - Provides a comprehensive overview of the many facets of DNA modifications - Discusses the impact of this dynamic epigenetic mechanism across brain development and lifespan at behavioral, cognitive, molecular and genetic levels - Contains contributions by influential leaders in the field - Edited by a Neuroscientist to further promote synthesis between epigenetics, neuroscience, and clinical relevance
Brain Iron Metabolism And Cns Diseases
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Author : Yan-Zhong Chang
language : en
Publisher: Springer Nature
Release Date : 2019-08-27
Brain Iron Metabolism And Cns Diseases written by Yan-Zhong Chang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-27 with Medical categories.
This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.
Neuroscience In The 21st Century
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Author : Donald W. Pfaff
language : en
Publisher: Springer Nature
Release Date : 2022-10-17
Neuroscience In The 21st Century written by Donald W. Pfaff and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-17 with Medical categories.
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its third edition serves as a comprehensive resource to students and researchers alike.
Rosenberg S Molecular And Genetic Basis Of Neurological And Psychiatric Disease Seventh Edition
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Author : Roger N. Rosenberg
language : en
Publisher: Elsevier
Release Date : 2024-10-04
Rosenberg S Molecular And Genetic Basis Of Neurological And Psychiatric Disease Seventh Edition written by Roger N. Rosenberg and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-04 with Medical categories.
Rosenberg's Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Seventh Edition, provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to neurologic and psychiatric disease. This volume has been thoroughly revised and includes newly commissioned chapters on ethics, genetic counselling and genet therapy for the central nervous system disorders. A favorite of over four generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the previous edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community at large. - Both volumes combined provide a comprehensive coverage on the neurogenetic foundation of neurological and psychiatric disease - This volume provides a detailed introduction on both the clinical and basic research implications of molecular and genetics surrounding the brain - Includes new chapters on genomics of human neurological disorders, CRISPR and genome engineering
Epigenetic Mechanisms Of Neurogenesis In The Developing Neocortex
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Author : Magdalena Götz
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-30
Epigenetic Mechanisms Of Neurogenesis In The Developing Neocortex written by Magdalena Götz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-30 with Science categories.
Stress Genetics Epigenetics And Genomics
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Author : George Fink
language : en
Publisher: Academic Press
Release Date : 2020-10-24
Stress Genetics Epigenetics And Genomics written by George Fink and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-24 with Science categories.
This fourth volume in the Handbook of Stress series, Stress: Genetics, Epigenetics and Genomics, deals with the influence that genetics, epigenetics, and genomics have on the effects of and responses to stress. Chapters refer to epigenetic mechanisms that involve DNA methylation, histone modification, and/or noncoding RNA-associated gene activation or silencing. There is also coverage of epigenetic mechanisms in stress-related transgenerational transmission of characteristics, and how these may help explain heritability in some complex human diseases.The Handbook of Stress series, comprised of self-contained volumes that each focus on a specific stress area, covers the significant advances made since the publication of Elsevier's Encyclopedia of Stress (2000 and 2007). Volume 4 is ideal for graduate students, post-doctoral fellows, faculty and clinicians interested in stress genetics, epigenetics and genomics involved in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry and the social sciences - Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge - Richly illustrated with explanatory figures and tables - Each chapter includes a boxed "Key points call out section - Affordably priced, self-contained volume for readers specifically interested in stress genetics and epigenetics, removing the need to purchase the whole Handbook series
Frontiers In Clinical Drug Research Cns And Neurological Disorders Volume 11
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Author : Zareen Amtul
language : en
Publisher: Bentham Science Publishers
Release Date : 2023-05-02
Frontiers In Clinical Drug Research Cns And Neurological Disorders Volume 11 written by Zareen Amtul and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-02 with Medical categories.
Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The eleventh volume of this series features reviews that cover the following topics related to the treatment of a variety of CNS disorders, related diseases, and basic research: - The Multi-target Directed Ligands candidate (MTDLs) prototypes for neurodegenerative diseases - Drugs for relapse prevention in addiction - Neuroprotective activities of cinnamic acids and their derivatives in neurodegenerative disorders - Phytosome for targeted delivery of natural compounds in treating alzheimer's disease - Physical activity as a non-pharmacologic method for treatment of alzheimer’s disease
Handbook Of Epigenetics
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Author : Trygve O. Tollefsbol
language : en
Publisher: Academic Press
Release Date : 2022-09-08
Handbook Of Epigenetics written by Trygve O. Tollefsbol and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-08 with Science categories.
Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses. In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources. - Provides a timely and comprehensive collection of fully up-to-date coverage of epigenetics - Covers basic epigenetic biology, research methods and technology, disease relationships and clinical medicine - Written at a verbal and technical level that can be understood by scientists and students alike, with chapter summaries and conclusions included throughout - Discusses exciting new topics in epigenetics, such as DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction - Includes step-by-step instructions in research protocols to aid reproducibility, as well as easy-to-digest disease case studies and clinical trials, providing context and applied examples of recent clinical translation
Two Faces Of Evil Cancer And Neurodegeneration
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Author : Thomas Curran
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-16
Two Faces Of Evil Cancer And Neurodegeneration written by Thomas Curran and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-16 with Science categories.
Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes
Knobil And Neill S Physiology Of Reproduction
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Author : Tony M. Plant
language : en
Publisher: Academic Press
Release Date : 2014-11-15
Knobil And Neill S Physiology Of Reproduction written by Tony M. Plant and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-15 with Science categories.
The Fourth Edition of Knobil & Neill continues to serve as a reference aid for research, to provide the historical context to current research, and most importantly as an aid for graduate teaching on a broad range of topics in human and comparative reproduction. In the decade since the publication of the last edition, the study of reproductive physiology has undergone monumental changes. Chief among these advances are in the areas of stem cell development, signaling pathways, the role of inflammation in the regulatory processes in the various tissues, and the integration of new animal models which have led to a greater understanding of human disease. The new edition synthesizes all of this new information at the molecular, cellular, and organismal levels of organization and present modern physiology a more understandable and comparative context. - The Fourth Edition has been extensively revised, reflecting new fundamental advancements in this rapidly advancing field. - Provides a common language for researchers across the fields of physiology, endocrinology, and biology to discuss their understanding of reproduction. - Saves academic researchers time in quickly accessing the very latest details on reproductive physiology, as opposed to searching through thousands of journal articles.