Epigenetic Mechanisms Of Neurogenesis In The Developing Neocortex
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Epigenetic Mechanisms Of Neurogenesis In The Developing Neocortex
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Author : Magdalena Götz
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-30
Epigenetic Mechanisms Of Neurogenesis In The Developing Neocortex written by Magdalena Götz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-30 with Science categories.
Neocortical Neurogenesis In Development And Evolution
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Author : Wieland B. Huttner
language : en
Publisher: John Wiley & Sons
Release Date : 2023-08-08
Neocortical Neurogenesis In Development And Evolution written by Wieland B. Huttner and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-08 with Medical categories.
NEOCORTICAL NEUROGENESIS IN DEVELOPMENT AND EVOLUTION Understanding the development and evolution of the mammalian neocortex The development of the mammalian brain, including the human brain, is inextricably linked with its evolution. Of particular interest is the development of the neocortex, the youngest part of the cerebral cortex in evolutionary terms and the seat of such vital functions as sensory perception, generation of motor commands, and higher-order cognition. The process of neurogenesis is crucial to the formation and function of the neocortex, but this process is complex, based on species-specific adaptations of old and acquired new traits that subserve specific functions introduced during mammalian evolution. Neocortical Neurogenesis in Development and Evolution provides a groundbreaking and comprehensive overview of neurogenesis in the developing neocortex and its evolutionary implications. It covers the generation of neurons and their migration to their functional positions, neural patterning, cortical folding, and variations and malformations of cortical development. Readers will find: A comprehensive review of the evolution and development of the neocortex in mammals — the part of our brain involved in the higher cognitive functions A multitude of subject disciplines ranging from neuroscience, molecular biology, genetics, developmental biology, evolutionary biology and medicine to provide a holistic understanding of the evolutionary youngest part of the cerebral cortex Coverage of neurogenesis in the developing neocortex and how this contributes to our understanding of the evolutionary implications Neocortical Neurogenesis in Development and Evolution is essential for researchers and postgraduates in neuroscience, developmental biology, evolutionary biology, and medical research.
Pharmacoepigenetics
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Author : Ramón Cacabelos
language : en
Publisher: Academic Press
Release Date : 2019-06-04
Pharmacoepigenetics written by Ramón Cacabelos and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-04 with Medical categories.
Pharmacoepigenetics provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. - Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development - Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry - Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety - Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine
The Neuroscience Of Normal And Pathological Development
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Author : Colin R Martin
language : en
Publisher: Academic Press
Release Date : 2021-10-12
The Neuroscience Of Normal And Pathological Development written by Colin R Martin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-12 with Psychology categories.
Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of Development is a comprehensive reference on the diagnosis and management of neurodevelopment and associated disorders. This book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of development-related conditions. Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. This book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. It also examines in vitro and in vivo modelling of development with stem cells and model systems.Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience Of Development: - Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of development - Features sections on diagnosis and biomarkers - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Focuses on neurodevelopmental disorders and environmental factors that influence neural development - Includes more than 500 illustrations and tables Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet: - Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of development - Features sections on the genetics of developmental conditions and accompanying behavior - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Focuses on neurodevelopmental disorders and environmental factors that influence neural development - Includes more than 500 illustrations and tables
Frontiers In Developmental Biology
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Author : Robert A. Meyers
language : en
Publisher: John Wiley & Sons
Release Date : 2019-05-28
Frontiers In Developmental Biology written by Robert A. Meyers and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-28 with Science categories.
This topical volume in the respected Encyclopedia series is the first in many years to bring together all important aspects of developmental biology in one source, from morphogenesis and organogenesis, via epigenetic regulation of gene expression to evolutionary developmental biology. The editor-in-chief has assembled an outstanding team of contributors to review these topics, creating an authoritative work for many years to come. The result is a unique, top-level reference in developmental biology for researchers, students and professionals alike.
Mechanisms Of Neuronal Migration During Corticogenesis
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Author : Chiaki Ohtaka-Maruyama
language : en
Publisher: Frontiers Media SA
Release Date : 2016-07-15
Mechanisms Of Neuronal Migration During Corticogenesis written by Chiaki Ohtaka-Maruyama and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-15 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
The cerebral cortex plays central roles in many higher-order functions such as cognition, language, consciousness, and the control of voluntary behavior. These processes are performed by the densely interconnected networks of excitatory pyramidal neurons and inhibitory interneurons, and the balanced development of these two types of neuron is quite important. During cortical development, pyramidal neurons and interneurons show quite different migratory behaviors: radial migration and tangential migration, respectively. Pyramidal neurons are generated in the ventricular zone of the dorsal telencephalon, and migrate radially along radial glial fibers toward the pial surface, forming a six-layered cortical structure in an “ inside-out” manner. On the other hand, cortical interneurons are generated in the medial and caudal ganglionic eminence in the ventral telencephalon, and follow long tangential migratory paths into the cortex. Defects in these migration processes result in abnormalities in the cortical layer structure and neuronal networks, which may cause various neurological and psychiatric conditions such as epilepsy and schizophrenia. Accordingly, besides basic scientific interest, elucidation of the mechanism of neuronal migration is essential for understanding the pathogenesis of these diseases. This Research Topic includes a series of articles ranging from the basic mechanism of neocortical development to the malformation and evolution of the neocortex. We do hope that the present ebook will further stimulate the interest in the fascinating investigations of neuronal migration and corticogenesis.
Handbook Of Epigenetics
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Author : Trygve O. Tollefsbol
language : en
Publisher: Academic Press
Release Date : 2022-09-08
Handbook Of Epigenetics written by Trygve O. Tollefsbol and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-08 with Science categories.
Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses. In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources. - Provides a timely and comprehensive collection of fully up-to-date coverage of epigenetics - Covers basic epigenetic biology, research methods and technology, disease relationships and clinical medicine - Written at a verbal and technical level that can be understood by scientists and students alike, with chapter summaries and conclusions included throughout - Discusses exciting new topics in epigenetics, such as DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction - Includes step-by-step instructions in research protocols to aid reproducibility, as well as easy-to-digest disease case studies and clinical trials, providing context and applied examples of recent clinical translation
Context Dependent Regulation Of Neurogenesis Common Themes And Unique Features Of The Neurogenic Process In Different Model Systems
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Author : Giuseppe Lupo
language : en
Publisher: Frontiers Media SA
Release Date : 2021-05-25
Context Dependent Regulation Of Neurogenesis Common Themes And Unique Features Of The Neurogenic Process In Different Model Systems written by Giuseppe Lupo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-25 with Science categories.
Patho Epigenetics Of Disease
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Author : Janos Minarovits
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-14
Patho Epigenetics Of Disease written by Janos Minarovits and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-14 with Medical categories.
In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences. Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases.
Epigenomic And Epitranscriptomic Basis Of Development And Human Disease
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Author : Yujing Li
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-05
Epigenomic And Epitranscriptomic Basis Of Development And Human Disease written by Yujing Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-05 with Science categories.