Dna Topoisomerases And Cancer

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Dna Topoisomerases And Cancer

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Author : Yves Pommier
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-21

Dna Topoisomerases And Cancer written by Yves Pommier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-21 with Medical categories.

DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.

Dna Topoisomerases In Cancer Therapy

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Author : Toshiwo Andoh
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Dna Topoisomerases In Cancer Therapy written by Toshiwo Andoh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators, especially Leroy Liu and his collaborators at Johns Hopkins University. Readers will find a series of chapters written by researchers actively engaged in the expanding field of topoisomerase and their inhibitors. The series of chapters cover review articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer drugs in mammals and in the yeast Saccharomyces cerevisiae, which has proved to be a superb model organism for studies of anticancer drugs. This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology.

Dna Topoisomerases In Cancer

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Author : Milan Potmesil
language : en
Publisher: Oxford University Press, USA
Release Date : 1991

Dna Topoisomerases In Cancer written by Milan Potmesil and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.

DNA Topoisomerases are a unique class of enzymes that are responsible for the control and modification of DNA topology (tertiary structure); one example of their function is the transformation of chromosomes from a supercoiled condensed state to uncoiled strands and vice versa. They are of interest both for their intrinsic role in cell biology (i.e. control of cell division) and also because some anticancer drugs, such as camptothecin, act by inhibiting their action.

Dna Topoisomerases And Cancer

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Author :
language : en
Publisher:
Release Date : 2011-09-21

Dna Topoisomerases And Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-21 with categories.

First Conference On Dna Topoisomerases In Cancer Chemotherapy

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Author :
language : en
Publisher:
Release Date : 1987

First Conference On Dna Topoisomerases In Cancer Chemotherapy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Antineoplastic agents categories.

Molecular Biology Of Dna Topoisomerases And Its Application To Chemotherapy

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Author : Toshiwo Andoh
language : en
Publisher: CRC Press
Release Date : 1992-10-26

Molecular Biology Of Dna Topoisomerases And Its Application To Chemotherapy written by Toshiwo Andoh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-10-26 with Medical categories.

Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy is based on conference proceedings from the International Symposium on DNA Topoisomerases in Chemotherapy, held in Nagoya, Japan, in November 1991. The book opens with a discussion of the structural and functional properties of various types of DNA topoisomerases identified in prokaryotes and eukaryotes, in addition to their roles as cellular targets of anticancer and antimicrobial agents. Other topics addressed include the genetics and biology of DNA topoisomerases, inhibitors of microbial DNA topoisomerases and drug resistance, inhibitors of mammalian DNA topoisomerases and drug resistance, and preclinical and clinical studies of DNA topoisomerase inhibitors. Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy will broaden the understanding of biology and genetics of DNA topoisomerases and contribute to the development of antimicrobial and anticancer agents-inhibitors of topoisomerases. It will be invaluable for oncologists, molecular biologists, cellular biologists, geneticists, biochemists, and pharmaceutical researchers.

Dna Topoisomerases

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Author : Duncan J. Clarke
language : en
Publisher: Methods in Molecular Biology
Release Date : 2009-09-25

Dna Topoisomerases written by Duncan J. Clarke and has been published by Methods in Molecular Biology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-25 with Medical categories.

DNA topoisomerases and gyrases have been studied thoroughly from a biochemical perspective, and expanding research at the molecular and cellular level shows great promise. This book gives a compendium of protocols that extends into such new areas of research.

First Conference On Dna Topoisomerases In Cancer Chemotherapy

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Author :
language : en
Publisher:
Release Date : 1987

First Conference On Dna Topoisomerases In Cancer Chemotherapy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Antineoplastic agents categories.

Dna Topoisomerases

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Author : Leroy F. Liu
language : en
Publisher:
Release Date : 1994

Dna Topoisomerases written by Leroy F. Liu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

Cytotoxic Payloads For Antibodydrug Conjugates

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Author : David E Thurston
language : en
Publisher: Royal Society of Chemistry
Release Date : 2019-07-11

Cytotoxic Payloads For Antibodydrug Conjugates written by David E Thurston and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-11 with Medical categories.

Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.