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Dna Topoisomerases In Cancer Chemotherapy

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Dna Topoisomerases And Cancer

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Author : Yves Pommier
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-21

Dna Topoisomerases And Cancer written by Yves Pommier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-21 with Medical categories.

DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.

Dna Topoisomerases In Cancer Therapy

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Author : Toshiwo Andoh
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Dna Topoisomerases In Cancer Therapy written by Toshiwo Andoh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators, especially Leroy Liu and his collaborators at Johns Hopkins University. Readers will find a series of chapters written by researchers actively engaged in the expanding field of topoisomerase and their inhibitors. The series of chapters cover review articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer drugs in mammals and in the yeast Saccharomyces cerevisiae, which has proved to be a superb model organism for studies of anticancer drugs. This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology.

First Conference On Dna Topoisomerases In Cancer Chemotherapy

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Author :
language : en
Publisher:
Release Date : 1987

First Conference On Dna Topoisomerases In Cancer Chemotherapy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Antineoplastic agents categories.

Dna Topoisomerases And Cancer

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Author :
language : en
Publisher:
Release Date : 2011-09-21

Dna Topoisomerases And Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-21 with categories.

Dna Topoisomerases In Cancer

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Author : Milan Potmesil
language : en
Publisher: Oxford University Press, USA
Release Date : 1991

Dna Topoisomerases In Cancer written by Milan Potmesil and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.

DNA Topoisomerases are a unique class of enzymes that are responsible for the control and modification of DNA topology (tertiary structure); one example of their function is the transformation of chromosomes from a supercoiled condensed state to uncoiled strands and vice versa. They are of interest both for their intrinsic role in cell biology (i.e. control of cell division) and also because some anticancer drugs, such as camptothecin, act by inhibiting their action.

Molecular Biology Of Dna Topoisomerases And Its Application To Chemotherapy

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Author : Toshiwo Andoh
language : en
Publisher: CRC Press
Release Date : 1992-10-26

Molecular Biology Of Dna Topoisomerases And Its Application To Chemotherapy written by Toshiwo Andoh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-10-26 with Medical categories.

Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy is based on conference proceedings from the International Symposium on DNA Topoisomerases in Chemotherapy, held in Nagoya, Japan, in November 1991. The book opens with a discussion of the structural and functional properties of various types of DNA topoisomerases identified in prokaryotes and eukaryotes, in addition to their roles as cellular targets of anticancer and antimicrobial agents. Other topics addressed include the genetics and biology of DNA topoisomerases, inhibitors of microbial DNA topoisomerases and drug resistance, inhibitors of mammalian DNA topoisomerases and drug resistance, and preclinical and clinical studies of DNA topoisomerase inhibitors. Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy will broaden the understanding of biology and genetics of DNA topoisomerases and contribute to the development of antimicrobial and anticancer agents-inhibitors of topoisomerases. It will be invaluable for oncologists, molecular biologists, cellular biologists, geneticists, biochemists, and pharmaceutical researchers.