Down Syndrome Neurodegeneration And Dementia
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Down Syndrome Neurodegeneration And Dementia
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Author : Sylvia Eva Perez
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-27
Down Syndrome Neurodegeneration And Dementia written by Sylvia Eva Perez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-27 with Science categories.
The Neurobiology Of Aging And Alzheimer Disease In Down Syndrome
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Author : Elizabeth Head
language : en
Publisher: Academic Press
Release Date : 2021-08-31
The Neurobiology Of Aging And Alzheimer Disease In Down Syndrome written by Elizabeth Head and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-31 with Medical categories.
The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. Discusses the complexities involved with aging and Alzheimer’s disease in Down syndrome Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research
Down Syndrome And Alzheimer S Disease
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Author : Vee Prasher
language : en
Publisher: CRC Press
Release Date : 2018-12-14
Down Syndrome And Alzheimer S Disease written by Vee Prasher and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-14 with Medical categories.
This is the first book in the field to address the underlying biological abnormalities of Dementia in Alzheimer’s Disease (DAD) in people with Down syndrome. It brings together research findings relating to the neuropathology, genetics, blood markers and neurophysiology of Alzheimer’s disease in older adults with Down syndrome. Down Syndrome and Alzheimer’s Disease presents vital information to medical professionals who provide clinical care to people with Alzheimer’s disease and Down syndrome. It will also be of great benefit to researchers with an interest in Alzheimer’s disease and Down syndrome and academics researching ageing issues in people with Down Syndrome. It complements Alzheimer's Disease and Dementia in Down Syndrome and Intellectual Disabilities by the same author.
Intellectual Disabilities In Down Syndrome From Birth And Throughout Life Assessment And Treatment
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Author : Marie-Claude Potier
language : en
Publisher: Frontiers Media SA
Release Date : 2017-02-24
Intellectual Disabilities In Down Syndrome From Birth And Throughout Life Assessment And Treatment written by Marie-Claude Potier and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-24 with Electronic book categories.
Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.
Alzheimer S Disease And Dementia In Down Syndrome And Intellectual Disabilities
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Author : Vee P. Prasher
language : en
Publisher: Radcliffe Publishing
Release Date : 2005
Alzheimer S Disease And Dementia In Down Syndrome And Intellectual Disabilities written by Vee P. Prasher and has been published by Radcliffe Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Alzheimer's disease categories.
The basic aim of this book is to help carers and professionals living or working with adults with intellectual disability to understand further Alzheimer's disease and other forms of dementia.
Down Syndrome And Alzheimer S Disease
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Author :
language : en
Publisher:
Release Date : 2009
Down Syndrome And Alzheimer S Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Down syndrome categories.
Neuropsychological Assessments Of Dementia In Down Syndrome And Intellectual Disabilities
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Author : Vee P. Prasher
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-04-29
Neuropsychological Assessments Of Dementia In Down Syndrome And Intellectual Disabilities written by Vee P. Prasher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-29 with Medical categories.
This book reviews important neuropsychological measures currently used in the assessment of dementia by the principal clinicians and researchers associated with the test, offering practical guidance on each test along with an analysis of its limitations.
Dementia Aging And Intellectual Disabilities
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Author : Matthew P. Janicki
language : en
Publisher: Psychology Press
Release Date : 1999
Dementia Aging And Intellectual Disabilities written by Matthew P. Janicki and has been published by Psychology Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Aged people with mental disabilities categories.
First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.
Down S Syndrome And Dementia
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Author : Diana Kerr
language : en
Publisher:
Release Date : 1997
Down S Syndrome And Dementia written by Diana Kerr and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Alzheimer's disease categories.
Recent Advances In Alzheimer Research
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Author : Ahmad Salehi
language : en
Publisher: Bentham Science Publishers
Release Date : 2015-11-11
Recent Advances In Alzheimer Research written by Ahmad Salehi and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-11 with Medical categories.
Recent Advances in Alzheimer Disease Research is a book series focusing on contemporary research on Alzheimer’s disease epidemiology, pathophysiology, diagnosis and therapy. The series features reviews by experts in neuroscience and aims to provide current information in the field to both researchers and clinicians. Down syndrome is a chromosomal disorder affecting more than 5.8 million individuals worldwide. Down syndrome can be viewed as a complex multi-system disorder as it manifests into significant physical, psychological, and cognitive abnormalities in affected persons. With aging, most adults with Down syndrome develop the clinical and neuropathological hallmarks of Alzheimer's disease. Unfortunately, no extant treatments have proven beneficial for cognitive dysfunction for either Down syndrome or Alzheimer’s disease. An incomplete understanding of the common pathogenic mechanisms that link these two disorders has limited researchers’ progress to this end. Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a novel attempt to fill this void, by summarizing the work of world-renowned scientists in the field of Alzheimer’s disease and Down syndrome, and thus providing an unprecedented opportunity to attract attention to Down syndrome as a tool for understanding the common molecular mechanisms that underlie Alzheimer’s disease and to develop new therapies for similar neurodegenerative disorders of the brain. The book covers the fundamental pathophysiology and molecular mechanisms behind the incidence of Alzheimer’s disease in Down syndrome affected individuals as well other key topics such as diagnosis and management, in vivo brain imaging studies, and progressive neurodegeneration of the monoaminergic system. The book concludes with a review of recent clinical trials of drugs designed to mitigate cognitive dysfunction in aging adults with Down syndrome and establishes a scientific warrant for the increased testing of candidate pharmacotherapies. Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a useful reference clinicians involved in treating Down syndrome patients as well as for neuroscience researchers seeking to understand the influence of a specific case of aneuploidy on Alzheimer’s disease incidence and its progression at the molecular level.