Drug Development For Parasite Induced Diarrheal Diseases
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Drug Development For Parasite Induced Diarrheal Diseases
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Author : Anjan Debnath
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-25
Drug Development For Parasite Induced Diarrheal Diseases written by Anjan Debnath and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-25 with Electronic book categories.
One of the top four contributors to the global burden of disease is diarrheal infections. Intestinal parasites are major causes of morbidity and mortality associated with diarrheal diseases in both the developed and developing world. Amebiasis is responsible for 50 million cases of invasive disease and 70,000 deaths annually in the world. Giardiasis has an estimated worldwide prevalence of 280 million cases annually. In developed countries, Giardia lamblia infects about 2% of adults and 6-8% of children. The prevalence of G. lamblia infection is generally higher in developing countries, ranging from 3% to 90%. Furthermore, giardial infections contribute substantially to the 2.5 million annual deaths from diarrheal disease. In Asia, Africa, and Latin America, about 500,000 new giardiasis cases are reported each year. Cryptosporidium accounts for 20% and 9% of diarrheal episodes in children in developing and developed countries, respectively. Infection with Cryptosporidium can be chronic and especially debilitating in immunosuppressed individuals and malnourished children. A recent study to measure disease burden, based on disability-adjusted life years (DALYs), found that cryptosporidiosis and amebiasis produce about 10.6 million DALYs. This exceeds the DALYs of any helminth infection currently being targeted by the World Health Organization for preventive chemotherapy. Because of its link with poverty, Giardia and Cryptosporidium were included in the WHO Neglected Diseases Initiative in 2004. E. histolytica, G. lamblia, and C. parvum have been listed by the National Institutes of Health (NIH) as category B priority biodefense pathogens due to low infectious dose and potential for dissemination through compromised food and water supplies in the United States. Despite the prevalence of amebiasis, giardiasis, and cryptosporidiosis there are no vaccines or prophylactic drugs. The first-line drugs for invasive amebiasis and giardiasis chemotherapy are nitroimidazoles, with the prototype, metronidazole, being the most common drug used worldwide. Metronidazole has been shown to be both mutagenic in a microbiological system and carcinogenic to rodents, and frequently causes gastrointestinal side effects. In spite of the efficacy of nitroimidazole drugs, treatment failures in giardiasis occur in up to 20% of cases. Clinical resistance of G. lamblia to metronidazole is proven and cross resistance is a concern with all commonly used antigiardial drugs. Nitazoxanide, the only FDA-approved drug for the treatment of cryptosporidiosis, is effective in the treatment of immunocompetent patients and partially effective for immunosuppressed patients. Therefore, it is critical to search for more effective drugs to treat amebiasis, giardiasis, and cryptosporidiosis. This Research Topic for Frontiers in Microbiology will explore the recent progress in drug development for parasitic diarrheal diseases. This includes an understanding of drug resistance mechanisms. We would also welcome submissions on the drug development for other diarrheal parasites. We hope that this research topic will include a comprehensive survey of various attempts by the parasitology research community to create effective drugs for these diseases.
Agriculture Rural Development Food And Drug Administration And Related Agencies Appropriations For 1997
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Author : United States. Congress. House. Committee on Appropriations Subcommittee on Agriculture, Rural Development, Food and Drug Administration, and Related Agencies
language : en
Publisher:
Release Date : 1996
Agriculture Rural Development Food And Drug Administration And Related Agencies Appropriations For 1997 written by United States. Congress. House. Committee on Appropriations Subcommittee on Agriculture, Rural Development, Food and Drug Administration, and Related Agencies and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with United States categories.
Advances In Molecular Biology Pathogenesis Diagnosis Vaccines And Treatment Of Diseases Caused By Apicomplexan Parasites
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Author : Mingming Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-26
Advances In Molecular Biology Pathogenesis Diagnosis Vaccines And Treatment Of Diseases Caused By Apicomplexan Parasites written by Mingming Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-26 with Science categories.
Departments Of Labor Health And Human Services Education And Related Agencies Appropriations For 1998
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Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
language : en
Publisher:
Release Date : 1997
Departments Of Labor Health And Human Services Education And Related Agencies Appropriations For 1998 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Political Science categories.
Malaria
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 1991-02-01
Malaria written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-02-01 with Medical categories.
Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
Disease Control Priorities Third Edition Volume 6
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Author : King K. Holmes
language : en
Publisher: World Bank Publications
Release Date : 2017-11-06
Disease Control Priorities Third Edition Volume 6 written by King K. Holmes and has been published by World Bank Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-06 with Medical categories.
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Wipo Re Search Collaborating To Mobilize The Power Of Intellectual Property For Global Health
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Author : World Intellectual Property Organization
language : en
Publisher: WIPO
Release Date : 2018-11-15
Wipo Re Search Collaborating To Mobilize The Power Of Intellectual Property For Global Health written by World Intellectual Property Organization and has been published by WIPO this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-15 with Law categories.
WIPO Re:Search aims to catalyze the development of medical products for neglected tropical diseases, malaria and tuberculosis through innovative research partnerships and knowledge sharing.
Apicomplexan Parasites
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Author : Katja Becker
language : en
Publisher: John Wiley & Sons
Release Date : 2011-01-19
Apicomplexan Parasites written by Katja Becker and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-19 with Medical categories.
This handbook is the first dealing with the discovery of drugs directed against apicomplexan parasites. Amongst others, this group of endoparasites includes the causative agents of Malaria, Toxoplasmosis, and Babesiosis, the latter occurring mainly in animals. Written by renowned scientific experts from academia and industry, the book focuses on currentdrug development approaches for all apicomplexan diseases making it appealing to a large audience, ranging from research labs in academia to the human and veterinarian pharmaceutical industry. This work is the second volume of the new book series 'Drug Discovery in Infectious Diseases', edited by Prof. Dr Paul M. Selzer.
Protein Phosphorylation In Parasites
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Author : Christian Doerig
language : en
Publisher: John Wiley & Sons
Release Date : 2013-10-11
Protein Phosphorylation In Parasites written by Christian Doerig and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-11 with Medical categories.
This is the first book to collect and summarize in one publication the efforts to use kinases or phosphatases for drug development against parasite infections. The editors and contributors comprise the Who is Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug development The result will be welcomed by everyone in academia and industry participating in the global effort to finally combat the major diseases caused by eukaryotic parasites. This is volume one of a two-volume treatise, the second being exclusively dedicated to efforts to combat malaria using the same approach.
Foodborne Parasites
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Author : Ynes R. Ortega
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-11-22
Foodborne Parasites written by Ynes R. Ortega and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-22 with Technology & Engineering categories.
This book examines the two major parasite groups that are transmitted via water or foods: the single-celled protozoa, and the helminths: cestodes (tapeworms), nematodes (round worms), and trematodes (flukes). Each chapter covers the biology, mechanisms of pathogenesis, epidemiology, treatment, and inactivation of these parasites. This important new text offers a better understanding of the biology and control of parasitic infections necessary to reduce or eliminate future outbreaks in the U.S. and elsewhere.