Drug Monitoring By Hplc
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Therapeutic Drug Monitoring And Toxicology By Liquid Chromatography
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Author : Steven H.Y. Wong
language : en
Publisher: Routledge
Release Date : 2017-09-19
Therapeutic Drug Monitoring And Toxicology By Liquid Chromatography written by Steven H.Y. Wong and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-19 with Medical categories.
This important, new reference provides the first , up-to-date, and comprehensive treatmentof the various liquid chromatography (LC) instrumentation for Therapeutic DrugMonitoring (TDM) and toxicology drug assays and reviews the clinical pharmacologyof major classes of drugs and their LC analyses.Written by authoritative contributors who bring many years of personal laboratory/clinical experience to the book, this interdisciplinary work : presents the principlesof TDM, sampling techniques, and various instrumentation topics, including computerinterfacing, mass spectrometry, fluorescence , electrochemical detection, and bloodcollection devices . .. examines six primary classes of drugs, complete with recommendedLC procedures and emphasizing recently introduced drugs and their LC analyses. .. and documents medicolegal guidelines and laboratory management considerations,providing a contemporary assessment of today's laboratory needs.The only practical, current guide available on the subject, Therapeutic Drug Monitoringand Toxicology by Li([uid Chromatography belongs in the personal libraries of clinicaland analytical chemists and biochemists, clinical pharmacologists, clinical toxicologists,clinical pathologists, immunologists, liquid chromatographers, mass spectroscopists, laboratorydirectors, laboratory instrument manufacturers , and medical technologists. Thebook is also vital supplementary reading for advanced undergraduate and graduate-levelclinical chemistry, toxicology, clinical pathology, and liquid chromatography course.
Drug Monitoring By Hplc
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Author : Victoria Samanidou
language : en
Publisher: Nova Science Publishers
Release Date : 2010
Drug Monitoring By Hplc written by Victoria Samanidou and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Drug monitoring categories.
Recently HPLC-MS/MS has gained increasing popularity in clinical laboratories due to the advantages of the technology over other methods, while the capital cost for instruments has been decreased. HPLC-MS/MS provides high specificity and sensitivity for the simultaneous measurement of several drugs and/or their major metabolites in one single analytical run. In this new book chromatographic methods published in the last decade are reviewed regarding their applicability to drug monitoring. HPLC methods for anti-cancer drugs, bronchodilators, cardiovascular drugs, antipsychotics, antibiotics, antiepileptic drugs, antidepressants, and immunosuppressants have been presented comprehensively regarding sample preparation and chromatographic separation. Supportive information has been included on HPLC analysis and sample preparation.
Therapeutic Drug Monitoring Of Antipsychotics Hplc Analytical Method Development And Pharmaceutical Advices To The Ward Clinicians For Successful Individualized Therapy
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Author : Mary Remigius Agatha Onuoha
language : en
Publisher:
Release Date : 2016
Therapeutic Drug Monitoring Of Antipsychotics Hplc Analytical Method Development And Pharmaceutical Advices To The Ward Clinicians For Successful Individualized Therapy written by Mary Remigius Agatha Onuoha and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Analytical Methods For Therapeutic Drug Monitoring And Toxicology
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Author : Q. Alan Xu
language : en
Publisher: John Wiley & Sons
Release Date : 2011-04-12
Analytical Methods For Therapeutic Drug Monitoring And Toxicology written by Q. Alan Xu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-12 with Science categories.
This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.
Kalman And Clark S Drug Assay
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Author : Arthur J. Atkinson (Jr.)
language : en
Publisher:
Release Date : 1984
Kalman And Clark S Drug Assay written by Arthur J. Atkinson (Jr.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Medical categories.
Handbook Of Analytical Therapeutic Drug Monitoring And Toxicology 1996
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Author : Steven H.Y. Wong
language : en
Publisher: CRC Press
Release Date : 2017-11-22
Handbook Of Analytical Therapeutic Drug Monitoring And Toxicology 1996 written by Steven H.Y. Wong and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-22 with Medical categories.
Adapting modern advances in analytical techniques to daily laboratory practices challenges many toxicologists, clinical laboratories, and pharmaceutical scientists. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you keep abreast of the innovative changes that can make your laboratory - and the studies undertaken in it - a success. This volume simplifies your search for appropriate techniques, describes recent contributions from leading investigators, and provides valuable evaluations and advice.
Advances In Chromatographic Techniques For Therapeutic Drug Monitoring
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Author : Amitava Dasgupta
language : en
Publisher: CRC Press
Release Date : 2009-10-06
Advances In Chromatographic Techniques For Therapeutic Drug Monitoring written by Amitava Dasgupta and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-06 with Medical categories.
For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for imp
Hplc Method Development For Pharmaceuticals
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Author : Satinder Ahuja
language : en
Publisher: Elsevier
Release Date : 2011-09-21
Hplc Method Development For Pharmaceuticals written by Satinder Ahuja and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-21 with Medical categories.
High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge. Covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory Provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities) Discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase
Handbook Of Drug Targeting And Monitoring
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Author : Boris Andreev
language : en
Publisher: Nova Science Publishers
Release Date : 2010
Handbook Of Drug Targeting And Monitoring written by Boris Andreev and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Drug monitoring categories.
Drug monitoring in clinical chemistry refers to the measurement of drug concentration in blood serum/plasma so that an optimal concentration is obtained to benefit patients with minimal toxic adverse effects. Drug delivery systems have been developed for enhancing the pharmacokinetic profile of any given active agent, increasing the accumulation at the target site, while minimising their systemic distribution. Magnetic colloids, for example, are very promising stimuli-sensitive drug delivery systems because of their magnetic-field responsiveness. This book describes the main synthesis strategies and surface functionalisation processes of magnetic colloids, giving an overview of the recent developments in magnetic drug targeting. The possibilities of very promising strategies for controlling the biodistribution profiles of chemotherapy agents are also investigated, including passive and active targeting strategies involving the use of drug carriers. Other chapters in this book examine the application of nanotechnology in pharmacotherapy, therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDS), a mathematical modelling approach to testing drug effects on Hepatitis C virus (HCV), and the recent developments in drug monitoring by high performance liquid chromatography (HPLC).
Drug Monitoring And Clinical Chemistry
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Author : Georg Hempel
language : en
Publisher: Elsevier
Release Date : 2004-05-15
Drug Monitoring And Clinical Chemistry written by Georg Hempel and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-05-15 with Science categories.
Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation, validation of the analytical methods and pharmacokinetic methods for interpreting the data. Areas where therapeutic drug monitoring is used frequently such as antibiotics, immunosuppressant drugs, antipsychotic and anticancer drugs will be discussed in detail. In addition, the important field of phenotyping and genotyping for therapy optimisation with special focus on real-life applications is also covered. The book contains important information for analyst working on drug analysis in clinical chemistry, hospital pharmacists involved in therapeutic drug monitoring, other pharmacists, chemists or physicians working on pharmacokinetic studies in industry or academia. In contrast to other books in this field, this book provides up-to-date information regarding both methodology and clinical applications. For the applications, only fields are described where therapeutic drug monitoring is used in clinical routine and provides benefit to the patients. Overview of all important field where therapeutic drug monitoring is applied All relevant analytical and computational methods are discussed Written by experts with a lot of practical experience in the field