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Drug Toxicity In Embryonic Development


Drug Toxicity In Embryonic Development
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Drug Toxicity In Embryonic Development I


Drug Toxicity In Embryonic Development I
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Author : Robert J. Kavlock
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Drug Toxicity In Embryonic Development I written by Robert J. Kavlock and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.


Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that the experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.



Drug Toxicity In Embryonic Development


Drug Toxicity In Embryonic Development
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Author : Robert J. Kavlock
language : en
Publisher:
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Drug Toxicity In Embryonic Development written by Robert J. Kavlock and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.




Drug Toxicity In Embryonic Development Ii


Drug Toxicity In Embryonic Development Ii
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Author : Robert J. Kavlock
language : en
Publisher: Springer
Release Date : 2011-11-23

Drug Toxicity In Embryonic Development Ii written by Robert J. Kavlock and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-23 with Medical categories.


Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.



Drug Toxicity In Embryonic Development Ii


Drug Toxicity In Embryonic Development Ii
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Author : Robert J. Kavlock
language : en
Publisher: Springer
Release Date : 1996-11-04

Drug Toxicity In Embryonic Development Ii written by Robert J. Kavlock and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-11-04 with Medical categories.


Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.



Drug Toxicity In Embryonic Development Ii


Drug Toxicity In Embryonic Development Ii
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Author : Robert J. Kavlock
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Drug Toxicity In Embryonic Development Ii written by Robert J. Kavlock and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.


Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.



Drug Toxicity In Embryonic Development I


Drug Toxicity In Embryonic Development I
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Author : Robert J. Kavlock
language : en
Publisher: Springer
Release Date : 1997

Drug Toxicity In Embryonic Development I written by Robert J. Kavlock and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.


Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that the experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.



Developmental Toxicology


Developmental Toxicology
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Author : CaroleAKimmel
language : en
Publisher: CRC Press
Release Date : 1994-06-30

Developmental Toxicology written by CaroleAKimmel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-06-30 with Medical categories.


The Second Edition of this highly regarded work provides a state-of-the-art review of developmental toxicology from basic science, clinical, epidemiological, and regulatory perspectives. This new edition highlights the latest approaches to understanding the mechanisms of developmental toxicity, testing pharmaceutical and environmental agents, and interpreting developmental toxicity data.; The contributors demonstrate how new information on molecular embryology and cell biology is being applied to problems in developmental toxicology. Chapters describe the effects of toxic exposure on the functional development of various organs, examine the relationship between maternal and developmental toxicity, and discuss current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the use of mathematical and statistical techniques in data interpretation, as well as to the regulatory aspects of testing and risk assessment. Other chapters focus on pre- and post conceptional clinical care and on genetic factors in clinical developmental toxicology.



Handbook Of Developmental Toxicology


Handbook Of Developmental Toxicology
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Author : Ronald D. Hood
language : en
Publisher: CRC Press
Release Date : 1996-10-23

Handbook Of Developmental Toxicology written by Ronald D. Hood and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-10-23 with Medical categories.


Developmental toxicology, an increasingly important area, encompasses the study of toxicant effects on development, from conception through puberty. The Handbook of Developmental Toxicology provides useful insights gained from hands-on experience, as well as a theoretical foundation. In this convenient reference you will find information not previously gathered in one source-including comparative developmental milestones, historical data, and a glossary of terms used in developmental toxicity evaluation. This handbook is a practical guide for individuals who are responsible for testing chemical agents and for regulatory scientists who must evaluate studies, interpret data, and perform risk assessments. Packed with features, the Handbook of Developmental Toxicology is ideal for training students and technicians in developmental toxicology.



Teratogenicity Testing


Teratogenicity Testing
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Author : Luís Félix
language : en
Publisher: Humana
Release Date : 2024-02-24

Teratogenicity Testing written by Luís Félix and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-24 with Science categories.


This fully updated volume collects laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. Beginning with a section detailing basic principles of teratogenicity, the book continues with application of in vitro models for teratogenic screening to predict toxicity in embryonic animals and humans, as well as a variety of well-established in vivo animal model tests, which offer solutions for evaluating the efficacy and the teratogenicity of compounds in preclinical trials before human safety testing. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Teratogenicity Testing: Methods and Protocols, Second Edition serves as an ideal guide to tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.



Developmental And Reproductive Toxicology


Developmental And Reproductive Toxicology
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Author : Ronald D. Hood
language : en
Publisher: CRC Press
Release Date : 2005-08-30

Developmental And Reproductive Toxicology written by Ronald D. Hood and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-08-30 with Medical categories.


Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers e