Effect Of Exercise On The Mrna Expression Of Growth Factors Metabolic Genes And Myosin Heavy Chain Isoforms In Skeletal Muscles Of The Rat
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Effect Of Exercise On The Mrna Expression Of Growth Factors Metabolic Genes And Myosin Heavy Chain Isoforms In Skeletal Muscles Of The Rat
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Author : Antonios Matsakas
language : en
Publisher: diplom.de
Release Date : 2004-09-27
Effect Of Exercise On The Mrna Expression Of Growth Factors Metabolic Genes And Myosin Heavy Chain Isoforms In Skeletal Muscles Of The Rat written by Antonios Matsakas and has been published by diplom.de this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-27 with Medical categories.
Inhaltsangabe:Abstract: Skeletal muscle is a complex and heterogeneous tissue capable of remarkable adaptation in response to various stimuli such as exercise training. Molecular biology approaches have made a large contribution to our current understanding of how mechanical loading can alter gene expression and muscle protein synthesis rates in skeletal muscle. The steady-state level of a given mRNA is a function of both its rate of synthesis and its rate of degradation, implying that the rate of change in response to a cellular stimulus is dependent on the dynamics of mRNA turnover. Changes in muscle mRNA steady-state levels can be taken as an index of changes in gene expression, constituting currently one of the best described and understood molecular events that underlie muscle plasticity. The discovery of new growth factors involved in the regulation of muscle development provides a better understanding of the molecular mechanisms involved in the adaptation of skeletal muscle to exercise training. Since it has been shown that changes in contractile function can be brought about by switching on one subset and repressing another subset of genes, it was hypothesized that the steady state level of multiple mRNAs (growth factors and metabolic genes) involved in regulatory functions in a muscle which is frequently recruited during exercise is different between endurance trained versus untrained rats. Recent scientific data indicate that myostatin constitutes a limiting factor in normal muscle development playing a crucial role in skeletal muscle hypertrophy. Nevertheless, there are only scarce data so far about the role of myostatin in the exercise-induced skeletal muscle adaptation. The transient changes in regulatory and structural gene expression provide the molecular basis of the adaptability of the skeletal muscle to exercise stimulus. To get an insight into the molecular mechanisms of skeletal muscle adaptation, the main objective of this study was to examine the effect of both the short- and long- term effect of exercise (five day of swimming vs. chronic wheel running) on IGF-I and MSTN (positive and negative skeletal muscle regulators respectively) mRNA contents in male Wistar rats. Potential increase of positive and/or decrease of negative regulators of muscle growth lead to enhanced muscle-progenitor proliferation providing a new perspective in the mechanism of muscle adaptability. It was hypothesized that exercise training could be [...]
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 2000
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medicine categories.
The Endocrine System In Sports And Exercise
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Author : William J. Kraemer
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15
The Endocrine System In Sports And Exercise written by William J. Kraemer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Medical categories.
This valuable new addition to the Encyclopaedia of Sports Medicine series provides a comprehensive and logical look at the principles and mechanisms of endocrinology as related to sports and exercise. It looks at growth hormone factors involved in exercise and the endocrinology of sport competition. It considers various factors and stresses on the body that may alter sporting performance. It covers topics from the acute responses and chronic adaptations of the human endocrine system to the muscular activity involved in conditioning exercise, physical labor, and sport activities. This book is an essential reference for helping to plan better programs of physical fitness, to prepare for sports competitions, and to manage the medical care of athletes.
Skeletal Muscle As A Response Target The Link Between Growth And Metabolism
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Author : Michael B. Ranke
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2006
Skeletal Muscle As A Response Target The Link Between Growth And Metabolism written by Michael B. Ranke and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2004
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Skeletal Muscle Plasticity In Health And Disease
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Author : Roberto Bottinelli
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-08
Skeletal Muscle Plasticity In Health And Disease written by Roberto Bottinelli and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-08 with Medical categories.
The ability of striated muscle tissue to adapt to changes in activity or in working conditions is extremely high. In some ways it is comparable to the ability of the brain to learn. The interest in muscle adaptation is increasing in relation to the idea that physical fitness helps in the prevention of disease, may counteract the loss of physical performance and generally improves wellbeing. Plasticity is the word used since the late 1970’s to indicate collectively all the processes and mechanisms which form the background of muscle adaptation. This book aims to provide a systematic updating of the available knowledge on molecular and cellular mechanisms, as well as on changes at whole muscle level. The book means to be a guide and a help for people who enter the field as PhD or medical students, but is also a tool for refreshing and updating knowledge for people already active in the field in basic sciences as well as in applied disciplines such as neurology, sports science and rehabilitation.
Stem Cells And Cell Signalling In Skeletal Myogenesis
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Author : D.A. Sassoon
language : en
Publisher: Elsevier
Release Date : 2002-02-08
Stem Cells And Cell Signalling In Skeletal Myogenesis written by D.A. Sassoon and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-02-08 with Science categories.
Skeletal muscle development is perhaps one of the best understood processes at the molecular, cellular and organismal level due in large part to the fact that primary myogenic cells (myoblasts) will grow and subsequently differentiate into myotubes in culture. With the advent of reverse mouse genetics, many of the observations gained through the study of myogenic cells in vitro have been directly tested in vivo. What has emerged is a complex but cohesive story of how myogenic cells are initially specified in the vertebrate embryo and how muscle fibers ultimately achieve their respective identities (i.e. fast versus slow) to perform their function. This collection of chapters is focused on these developments. The book discusses old and new directions for the skeletal muscle field and points out directions where the field may eventually progress.
Thyroid And Heart Failure
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Author : Giorgio Iervasi
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-08-29
Thyroid And Heart Failure written by Giorgio Iervasi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-29 with Medical categories.
Both thyroid dysfunction and heart failure show a high prevalence in the adult population. Frequently, in clinical practice, a multidisciplinary approach is useful to optimize the management of patients with these conditions. Although there is no doubt regarding the close link between cardiovascular pathophysiology and thyroid homeostasis, our understanding of this association is far from being exhaustive. Thyroid hormone regulates the expression of cardiac-specific functional contractile and structural proteins and plays a pivotal role in modulating both diastolic and systolic function as well as peripheral vascular resistance. The close relationship between thyroid and heart dysfunction is strongly supported by recent evidence demonstrating that an altered thyroid profile is a negative prognostic predictor in patients with heart failure. The treatment of chronic heart failure, especially in advanced stages of the disease, continues to be an open and challenging field. The potential of novel thyroid hormone therapies that address the molecular biology of thyroid dysfunction and heart failure thus represents an attractive area of multidisciplinary scientific interest. This book is a readable, integrated, and highly up to date presentation of the clinical, pathophysiological, and basic science aspects of thyroid–heart failure interactions. It addresses a complex subject in an approach that targets a large audience of readers.
The Biology Of Exercise
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Author : Michael J. Joyner
language : en
Publisher: Perspectives Cshl
Release Date : 2017
The Biology Of Exercise written by Michael J. Joyner and has been published by Perspectives Cshl this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medical categories.
Exercise training provokes widespread transformations in the human body, requiring coordinated changes in muscle composition, blood flow, neuronal and hormonal signaling, and metabolism. These changes enhance physical performance, improve mental health, and delay the onset of aging and disease. Understanding the molecular basis of these changes is therefore important for optimizing athletic ability and for developing drugs that elicit therapeutic effects. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biological basis of exercise from the molecular to the systemic levels. Contributors discuss how transcriptional regulation, cytokine and hormonal signaling, glucose metabolism, epigenetic modifications, microRNA profiles, and mitochondrial and ribosomal functions are altered in response to exercise training, leading to improved skeletal muscle, hippocampal, and cardiovascular function. Cross talk among the pathways underlying tissue-specific and systemic responses to exercise is also considered. The authors also discuss how the understanding of such molecular mechanisms may lead to the development of drugs that mitigate aging and disease. This volume will therefore serve as a vital reference for all involved in the fields of sports science and medicine, as well as anyone seeking to understand the molecular mechanisms by which exercise promotes whole-body health.
Frontiers In Skeletal Muscle Wasting Regeneration And Stem Cells
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Author : Carlos Hermano J. Pinheiro
language : en
Publisher: Frontiers Media SA
Release Date : 2016-05-25
Frontiers In Skeletal Muscle Wasting Regeneration And Stem Cells written by Carlos Hermano J. Pinheiro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-25 with Electronic book categories.
The search for knowledge on cellular and molecular mechanisms involved in skeletal muscle mass homeostasis and regeneration is an exciting scientific area and extremely important to develop therapeutic strategies for neuromuscular disorders and conditions related to muscle wasting. The mechanisms involved in the regulation of skeletal muscle mass and regeneration consist of molecular signaling pathways modulating protein synthesis and degradation, bioenergetics alterations and preserved function of muscle stem cells. In the last years, different kinds of stem cells has been reported to be localized into skeletal muscle (satellite cells, mesoangioblasts, progenitor interstitial cells and others) or migrate from non-muscle sites, such as bone marrow, to muscle tissue in response to injury. In addition, myogenic progenitor cells are also activated in skeletal muscle wasting disorders. The goal of this research topic is to highlight the available knowledge regarding skeletal muscle and stem cell biology in the context of both physiological and pathological conditions. Our purpose herein is to facilitate better dissemination of research into skeletal muscle physiology field. Frontiers in Physiology is a journal indexed in: PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef.