Emerging Roles And Mechanisms Of Stromal Cells In Carcinomas At The Molecular Level
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Emerging Roles And Mechanisms Of Stromal Cells In Carcinomas At The Molecular Level
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Author : Jaewoo Hong
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-18
Emerging Roles And Mechanisms Of Stromal Cells In Carcinomas At The Molecular Level written by Jaewoo Hong and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-18 with Medical categories.
Mesenchymal Stromal Cells As Tumor Stromal Modulators
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Author : Marcela Bolontrade
language : en
Publisher: Academic Press
Release Date : 2016-10-24
Mesenchymal Stromal Cells As Tumor Stromal Modulators written by Marcela Bolontrade and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-24 with Medical categories.
Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges
The Unfolded Protein Response In Cancer
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Author : Robert Clarke
language : en
Publisher: Springer
Release Date : 2019-03-01
The Unfolded Protein Response In Cancer written by Robert Clarke and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-01 with Medical categories.
This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.
The Tumor Stroma
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Author : Jai Prakash
language : en
Publisher: CRC Press
Release Date : 2022-01-27
The Tumor Stroma written by Jai Prakash and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-27 with Medical categories.
The identification of the role of tumor stroma—the tissue in the surroundings of cancer cells—in cancer development, progression, and metastasis has revolutionized the fields of cancer biology as well as cancer therapeutics. This book provides a comprehensive overview of this rapidly-evolving field including tumor stroma biology, therapeutic targets, molecular imaging, and advanced tumor stroma in vitro models. The book will serve as a handbook for graduate students, postgraduate researchers, pharmaceutical scientists, and biomedical engineers.
New Roles Of Autophagy Pathways In Cancer
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Author : Daniel Hector Grasso
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-10
New Roles Of Autophagy Pathways In Cancer written by Daniel Hector Grasso and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-10 with Science categories.
Tumor Microenvironment Molecular Mechanisms And Signaling Pathways Involved In Metastatic Progression
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Author : Antonella Zannetti
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-30
Tumor Microenvironment Molecular Mechanisms And Signaling Pathways Involved In Metastatic Progression written by Antonella Zannetti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-30 with Medical categories.
Cancer Immunotherapy Immuno Monitoring Mechanism Treatment Diagnosis And Emerging Tools
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Author : Chao Ma
language : en
Publisher: Frontiers E-books
Release Date : 2014-12-16
Cancer Immunotherapy Immuno Monitoring Mechanism Treatment Diagnosis And Emerging Tools written by Chao Ma and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-16 with Cancer categories.
In the past decade, significant progresses have taken place in the field of cancer immunotherapy. Tumor-targeting immunotherapies are being developed for most human cancers, including melanoma, prostate cancer, glioblastoma, sarcoma, lung carcinoma and hepatocellular carcinoma. The FDA has approved multiple molecular immunotherapeutics, such as Ipilimumab; cellular immunotherapies (e.g. adoptive cell transfer) are being tested in phase II/III clinical trials. Immunotherapetics has evolved into a sophisticated field: Multimodal therapeutic regimens are administrated to induce focused responses, curtail side- effects and improve therapeutic efficacy. The lack of effective clinical assessment tools remains a major challenge. Because of the intricacy of antitumor response, it is essential to scrutinize individual tumor-targeting immune cells and their functions at the finest details – molecules. In this regard, flow cytometry analysis modernized hematology and allows characterization of surface molecular signature on individual cells. More recently, microchip technologies and new variations of cytometry have enormously expanded the spectrum, throughout and multiplexity of single cell analysis. Nowadays, tens of millions of readouts can be generated through the course of a cancer immunotherapy to monitor the abundance, phenotype and a myriad of effector functions of single immune cells. At the same time, big data analytics and data mining methodologies have been adapted to achieve sensible diagnostic interpretations. Such a marriage of technology and analytics opens the door for informative point-of-care assessment of therapeutic efficacy and ensures timely therapeutic decisions. The new generation of personalized clinical diagnostics will revolutionize healthcare in the years to come.
The Cancer Stem Cell Niche
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Author : Susie Nilsson
language : en
Publisher: Academic Press
Release Date : 2021-02-09
The Cancer Stem Cell Niche written by Susie Nilsson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-09 with Science categories.
The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche
Inflammation And Cancer
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Author : Bharat B. Aggarwal
language : en
Publisher: Springer
Release Date : 2014-05-12
Inflammation And Cancer written by Bharat B. Aggarwal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-12 with Medical categories.
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Cancer Metastasis Molecular And Cellular Mechanisms And Clinical Intervention
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Author : Wen G. Jiang
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11
Cancer Metastasis Molecular And Cellular Mechanisms And Clinical Intervention written by Wen G. Jiang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.
This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology.