Emerging Roles Of The Gut Microbiota In The Pathogenesis Of Metabolic Disorders
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Emerging Roles Of The Gut Microbiota In The Pathogenesis Of Metabolic Disorders
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Author : Isabel Moreno-Indias
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-01
Emerging Roles Of The Gut Microbiota In The Pathogenesis Of Metabolic Disorders written by Isabel Moreno-Indias and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-01 with Medical categories.
Role Of Flavonoids In Chronic Metabolic Diseases
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Author : Neeraj Mishra
language : en
Publisher: John Wiley & Sons
Release Date : 2024-08-28
Role Of Flavonoids In Chronic Metabolic Diseases written by Neeraj Mishra and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-28 with Technology & Engineering categories.
This comprehensive volume covers the entire field of flavonoids by explaining their complex functions in reducing chronic metabolic illnesses, from the early stages of laboratory research to the development of therapeutic uses. Flavonoids are plant-based substances proven to have potential medical benefits in managing chronic metabolic disorders. This book explores concepts in laboratory research and therapeutic capabilities to enhance awareness of flavonoids in a medical context. The book begins with a thorough examination of the basic biochemical and molecular processes that underlie long-term metabolic disorders. It looks into these bioactive substances, from their natural origins to the synthesis of innovative derivatives. Analyzing both lab research and preclinical trials critically, it provides a solid basis for understanding the exciting opportunities flavonoids bring in treating metabolic diseases. The scope of this work extends beyond theoretical domains into clinical environments. It closes the gap between bench-side findings and bedside applications by revealing the translational potential of flavonoids. It is possible to understand the practical implications and future directions of flavonoid-based therapeutics through the synthesis of evidence-based clinical studies, therapeutic approaches, and possible healthcare issues. Readers will find the book: contains cutting-edge insights into metabolic disease research and delves into recent discoveries on the molecular mechanisms of flavonoids; facilitates a viewpoint into the findings of practical clinical implementations and the progression of flavonoid investigations from controlled experimental environments to prospective therapeutic interventions; explores the scientific effects of flavonoids on chronic metabolic disorders; presents evidence from human trials and epidemiological research on flavonoid clinical processes; encompasses various aspects of preventive measures for managing widespread metabolic diseases, containing dietary recommendations, lifestyle interventions, and the potential involvement of flavonoids; offers a comprehensive guide on how to effectively utilize flavonoids for therapeutic purposes. Audience This book is intended for researchers, scientists, clinicians/physicians, and public health professionals who work in pharmacology settings. The book is a vital tool for clinicians, nutritionists, and other healthcare professionals who are concerned about cutting-edge methods for dietary guidelines to gain an understanding of flavonoids and long-term metabolic disorders.
Central Regulation Of Metabolism
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Author : Hu Huang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-04
Central Regulation Of Metabolism written by Hu Huang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-04 with Science categories.
Metabolic Steatotic Liver Disease
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Author : Mindie Nguyen
language : en
Publisher: Elsevier
Release Date : 2024-06-21
Metabolic Steatotic Liver Disease written by Mindie Nguyen and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-21 with Science categories.
Metabolic Fatty Liver Disease: Current Knowledge, Therapeutic Treatments, and Future Directions provides the most updated research findings and defines the current data gaps on metabolic fatty liver disease. The book extensively covers key areas in metabolic fatty liver disease research, including epidemiology (adults and children), economic burden, patient-reported outcome burden, natural history, current treatments, current diagnostic methods, controversies (NAFLD/MAFLD), current guidelines, fatty liver disease in the presence of other liver diseases as well as guidance on future research. This book will provide translational researchers with a current and comprehensive resource dedicated to all aspects of research in metabolic fatty liver disease, identify current gaps in research and make future research recommendations. It also offers clinicians a look at important background information in metabolic fatty liver disease and thoroughly reviews the latest research in this area to inform treatment outcomes. - Compiles the latest, up-to-date science from key experts in the field on metabolic fatty liver disease - Reviews best practices and current guidelines for a comprehensive overview - Identifies recommendations for future research endeavors
Gut Microbiome And Brain Ageing
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Author : Surajit Pathak
language : en
Publisher: Springer Nature
Release Date : 2024-04-18
Gut Microbiome And Brain Ageing written by Surajit Pathak and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-18 with Science categories.
This book, Gut microbiome and Brain Ageing, deals with the mechanisms and phenomenon that relates gut microbiome and aging of the brain. This book will bring forth the connection between good gut and brain aging and includes some cutting edge research topics dealing with gut physiology and its importance as future therapeutic option in neurological disorders. The gut microbiome's impact on neuronal function, mediated by neurotransmitters, vitamins, and neuroactive microbial metabolites, is an exciting area of investigation that this book thoroughly explores. It also covers the pivotal role of the gut microbiome in the etiology of various neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), depression, or multiple sclerosis (MS). It also explores the expanding understanding of the importance of the early-life gut microbiota and its implications for long-term health consequences. This book primarily addresses researchers, clinicians, and doctoral andgraduate students working in biomedicine, neurobiology, nutrition, microbiology, and translational medicine streams.
Handbook Of Microbiome And Gut Brain Axis In Alzheimer S Disease
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Author : G.M. Pasinetti
language : en
Publisher: IOS Press
Release Date : 2022-07-05
Handbook Of Microbiome And Gut Brain Axis In Alzheimer S Disease written by G.M. Pasinetti and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-05 with Medical categories.
Despite being confined to the gastrointestinal tract, the gut microbiome has a wide impact on human physiology, supplementing its host’s biochemistry in a complex symbiotic relationship. Research in the field has evolved rapidly in the last decade, and we are now developing a better understanding of how our gut microbiome can influence our immune systems, metabolism, neurological signaling, and perhaps most unexpectedly, our brains; a phenomenon described as the gut-brain-axis. This book, ‘Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s Disease’, sets out to explore the complex role of the microbiome with regard to Alzheimer’s disease (AD). The microbiome is a critical and often overlooked aspect of immunity, which in turn plays a role in cognition. The book presents current research into the gut microbiota and its far-reaching impacts on cognitive function and neurodegeneration. Interventions, including probiotic supplementation, fecal transfer, and supplementation with microbial metabolites, are discussed, as is the use of certain probiotics to study the effects of the gut microbiota on behavior and cognitive function, and as potential therapeutics for AD. Other topics covered include the influence of the gut and oral microbiota on immune inflammatory signals: cytokines, neuroendocrine hormones, bacterial components, neuroactive molecules, and microbial metabolites. The book is divided into four sections, each covering a research area pertinent to the gut-brain-axis and its relationship with cognitive function and AD. It will be of interest to all those whose work includes the study and understanding of these complex, multi-variable biological mechanisms, particularly in the context of cognitive function and AD. The cover shows a color edited MRI image of a sagittal section of a neurological control brain of Dr. Giulio Maria Pasinetti.
The Alzheimer S Disease Challenge
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Author : Athanasios Alexiou
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-04
The Alzheimer S Disease Challenge written by Athanasios Alexiou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-04 with categories.
Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. This Frontiers eBook offers a contribution of 39 innovative papers on the multidimensional and crucial problem of Alzheimer’s disease management and treatment. Several perspectives, research updates, and trials describing methods on potential diagnosis and treatment are presented including biological mechanisms, biomarkers and risk factors for an early and efficient prognosis, diagnosis and prevention. Additionally, while the rapidly increasing Alzheimer’s disease population demands holistic solutions and clinical studies with new therapeutic target approaches, several of the contributive papers present promising drugs targeting Alzheimer’s disease treatment. We give our deepest acknowledgment to all the authors for their important and innovative contributions, to the reviewers for their valuable recommendations on improving the submitting studies and all the Frontiers Editorial team for continuous support.
Role Of Microbiome In Disease Diagnostics And Therapeutics
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Author : Nar Singh Chauhan
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-07
Role Of Microbiome In Disease Diagnostics And Therapeutics written by Nar Singh Chauhan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-07 with Science categories.
The Gut Liver Axis The Main Role Of Microbiome In Liver Diseases
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Author : Giovanni Tarantino
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-25
The Gut Liver Axis The Main Role Of Microbiome In Liver Diseases written by Giovanni Tarantino and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-25 with Science categories.
The Gut-Liver Axis describes a bidirectional interaction between the gut comprehending its mi-crobiome and the liver, in which gut-derived molecules and/or by-products are transported to the hepatocytes through the portal vein and the liver responds to the gut through the biliary system. Intestinal ecological dysbiosis refers to alterations in the intestinal flora characterized by changes in the intestinal bacterial taxa, and bacterial overgrowth itself may lead to impaired small intesti-nal motility. The integrity of this intestinal mucosal barrier and the physiological composition of the intestinal microbiome is essential for maintaining homeostasis of the gut-liver axis and its al-terations may impact on several liver diseases, such as NAFLD, liver cirrhosis and hepatocarcino-ma. Last but not the least, intestinal dysbiosis has a key role in modulating the hepatotoxicity (DILI) of clinically relevant drugs through various mechanisms that include changes in absorption, metabolism and effects on drug-drug interactions. With this research topic we aim to gather new pieces of evidence on the potential mechanisms ex-plaining the connection between gut flora dysbiosis and liver damage: 1. The impairment of hepatocyte survival by toxic compounds generated by intestinal bacteria 2. The triggering of immune/inflammatory processes by toxic compounds generated by dysbiotic bacteria in the gut and transported to the liver 3. The genotoxicity on liver cells of gut bacterial mediators 4. The epigenetic modifications in the hepatocytes induced by intestinal bacteria 5. The impairment of the enterohepatic circulation of bile acids 6. The connection between microbiota-induced NAFLD/NASH and the risk of DILI 7. The conversion of orally-given drugs into toxic metabolites through bacterial metabolism taking place in the gut lumen 8. The disruption of the integrity of the epithelial intestinal barrier with the consequent bacte-rial translocation through a direct action of drugs on the intestinal mucosa 9. The modulation by the gut microbiota of the rewarding potential of hepatotoxic drugs of abuse leading to an increase in craving for these substances and ultimately in their intake and liver toxicity 10. The hypothesis that strategies aiming to modify the composition of gut microbiota with probiotics/prebiotics/symbiotics could ameliorate or prevent liver diseases.
Developmental Origins Of Health And Disease
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Author : Lucilla Poston
language : en
Publisher: Cambridge University Press
Release Date : 2022-12-22
Developmental Origins Of Health And Disease written by Lucilla Poston and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-22 with Medical categories.
The concept of the early life developmental origins of health and disease (DOHaD) in adults has stimulated a new approach to understanding disease trajectories, with major public health implications. Indeed, the principle of the 'lifecourse of disease' now influences health policies internationally. Environmental influences during pregnancy and early life that affect lifelong health are well documented, but there is a new focus on the preconception period and the significance of paternal health on the fetus. This fully revised second edition highlights scientific and clinical advances in the field, exploring new understanding of mechanisms such as epigenetics and the increasingly recognised role of external influences, including pollution. The book is structured logically, covering environment, clinical outcomes, mechanisms of DOHaD, interventions throughout the lifespan and finally implications for public health and policy. Clinicians and scientists alike will improve their understanding of the developmental origins of health and disease with this essential text.