Engineering Translational Models Of Lung Homeostasis And Disease
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Engineering Translational Models Of Lung Homeostasis And Disease
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Author : Chelsea M. Magin
language : en
Publisher:
Release Date : 2023
Engineering Translational Models Of Lung Homeostasis And Disease written by Chelsea M. Magin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners. Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, mechanics, and composition of the extracellular matrix. This information paves the way for tissue-informed engineering models of pulmonary tissue, improved design of clinical materials, and advances against a variety of common pathologies. Current translational challenges are highlighted, as are engineering opportunities to overcome these barriers. This foundational text holds valuable lessons for researchers and clinicians throughout the fields of engineering, materials science, cell biology, pulmonary medicine, and clinical science. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Engineering Translational Models Of Lung Homeostasis And Disease
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Author : Chelsea M. Magin
language : en
Publisher: Springer Nature
Release Date : 2023-05-17
Engineering Translational Models Of Lung Homeostasis And Disease written by Chelsea M. Magin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-17 with Science categories.
Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners. Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, mechanics, and composition of the extracellular matrix. This information paves the way for tissue-informed engineering models of pulmonary tissue, improved design of clinical materials, and advances against a variety of common pathologies. Current translational challenges are highlighted, as are engineering opportunities to overcome these barriers. This foundational text holds valuable lessons for researchers and clinicians throughout the fields of engineering, materials science, cell biology, pulmonary medicine, and clinical science. · Each section focuses on a specific region of the lung, presenting either the biological or clinical perspective along with complimentary engineering approaches · Covers the interface of engineering and lung biology · Highlights emerging new models to study lung disease and repair Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com
Stem Cell Based Therapy For Lung Disease
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Author : Janette K. Burgess
language : en
Publisher: Springer
Release Date : 2020-12-20
Stem Cell Based Therapy For Lung Disease written by Janette K. Burgess and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-20 with Science categories.
This book presents state-of-the-art pre-clinical models and clinical applications of stem-cell-based therapies applied to different lung diseases, with a special focus on the translation of bench data into clinical studies. Starting with the assumption that abnormal lung tissue repair and regeneration has emerged as the driving force underlying pathogenesis and progression in many lung diseases, it sheds new light on the potential of stem/stromal cells as drivers of repair and sources of reparative factors in the lung. The first part of the book offers an overview of stem cell types and mechanisms involved in lung development, homeostasis, repair and regeneration, and reveals the crucial role of the extracellular matrix within the lung microenvironment. In the second part, leading experts present the latest pre-clinical evidence and clinical applications of stem-cell-based therapies in a wide variety of lung diseases, ranging from COPD and lung fibrosis to other rare lung diseases. The last section discusses stem cell delivery systems and devices, such as aerosolised spray application. This book appeals to pneumologists, stem cell and matrix biologists, as well as bioengeneers with a special interest in regenerative medicine applied to pulmonary diseases.
Lung Stem Cells In Development Health And Disease
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Author : Nikolic, Marko Z.
language : en
Publisher: European Respiratory Society
Release Date : 2021-04-01
Lung Stem Cells In Development Health And Disease written by Nikolic, Marko Z. and has been published by European Respiratory Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-01 with Medical categories.
Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science
Innovative 3d Models For Understanding Mechanisms Underlying Lung Diseases Powerful Tools For Translational Research
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Author : Janette K. Burgess
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-05
Innovative 3d Models For Understanding Mechanisms Underlying Lung Diseases Powerful Tools For Translational Research written by Janette K. Burgess and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-05 with Science categories.
The mechanisms underlying acute and chronic lung diseases are complex, reflecting the interplay between multiple cell types, their microenvironment and exogenous challenges. While traditional in vitro cell culture approaches have been instrumental in advancing our knowledge of cellular signalling and function, they typically lack the cell-cell and cell-matrix interactions that define the niche in which lung cell and tissue functions emerge. Implementing in vivo and ex vivo three-dimensional (3D) models more realistically mimicking the in vivo cell-extracellular matrix (ECM) crosstalk should facilitate a considerable leap towards better understanding lung diseases and thus in investigating new pharmacological tools. We are experiencing a revolution in our understanding of the cell types that deposit and remodel ECM in the lung, the dynamic spatial composition of the ECM and cell-cell interactions during disease, and the influence of ECM and cell-derived cues on lung cell biology. In concert, the ex vivo and in vitro models that are being used to examine the role of the 3D microenvironment of the cell in the lung are rapidly developing. The European Respiratory Society has partnered with Frontiers in Pharmacology to launch this research topic in conjunction with the ERS Research Seminar “Innovative 3D models for understanding mechanisms underlying lung diseases: powerful tools for translational research”.
Organ Microenvironment In Vascular Formation Homeostasis And Engineering
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Author : Akiko Mammoto
language : en
Publisher: Frontiers Media SA
Release Date : 2023-02-09
Organ Microenvironment In Vascular Formation Homeostasis And Engineering written by Akiko Mammoto and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-09 with Science categories.
Mechanobiology In Health And Disease
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Author : Stefaan Verbruggen
language : en
Publisher: Academic Press
Release Date : 2018-08-09
Mechanobiology In Health And Disease written by Stefaan Verbruggen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-09 with Technology & Engineering categories.
Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science
Innovative In Vitro Models For Pulmonary Physiology And Drug Delivery In Health And Disease
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Author : Josue Sznitman
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-28
Innovative In Vitro Models For Pulmonary Physiology And Drug Delivery In Health And Disease written by Josue Sznitman and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-28 with Medical categories.
Skin Tissue Engineering And Regenerative Medicine
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Author : Mohammad Albanna
language : en
Publisher: Academic Press
Release Date : 2016-01-14
Skin Tissue Engineering And Regenerative Medicine written by Mohammad Albanna and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-14 with Technology & Engineering categories.
The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. From burn victims to surgical scars and plastic surgery, the therapies resulting from skin tissue engineering and regenerative medicine are important to a broad spectrum of patients. Skin Tissue Engineering and Regenerative Medicine provides a translational link for biomedical researchers across fields to understand the inter-disciplinary approaches which expanded available therapies for patients and additional research collaboration. This work expands on the primary literature on the state of the art of cell therapies and biomaterials to review the most widely used surgical therapies for the specific clinical scenarios. Explores cellular and molecular processes of wound healing, scar formation, and dermal repair Includes examples of animal models for wound healing and translation to the clinical world Presents the current state of, and clinical opportunities for, extracellular matrices, natural biomaterials, synthetic biomaterials, biologic skin substitutes, and adult and fetal stem and skin cells for skin regenerative therapies and wound management Discusses new innovative approaches for wound healing including skin bioprinting and directed cellular therapies
The Innate Immune Response To Noninfectious Stressors
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Author : Massimo Amadori
language : en
Publisher: Academic Press
Release Date : 2016-02-23
The Innate Immune Response To Noninfectious Stressors written by Massimo Amadori and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-23 with Medical categories.
The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation. Provides insights into the fundamental homeostatic processes vis-à-vis stressors to help in investigation Illustrates the depicted tenets and how to offset them against established models of response to physical and psychotic stressors in both animals and humans Covers the crucial issue of the immune response to endocrine disruptors Includes immunological parameters as reporter system of environmental adaptation Provides many illustrative examples to foster reader understanding