Epigenetics And Pathology
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Epigenetics And Pathology
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Author : Kasirajan Ayyanathan
language : en
Publisher: CRC Press
Release Date : 2013-11-25
Epigenetics And Pathology written by Kasirajan Ayyanathan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-25 with Science categories.
This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including: host-pathogen interactions causal relationships between genes and the environment the effects of environmental chemicals on gene expression DNA methylation The book also covers the analysis and provides models for understanding the epigenetics-pathology connection. This book is designed for use by senior undergraduate and graduate students from several disciplines such as general, molecular, cellular biology, genetics, genomics, proteomics, and bioinformatics. It will also serve as a reference book for existing researchers and new investigators entering this rather unexplored field.
Epigenetic Epidemiology
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Author : Karin B. Michels
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-03
Epigenetic Epidemiology written by Karin B. Michels and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-03 with Medical categories.
The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!
Chromatin And Epigenetics An Introduction To Epigenetic Mechanisms
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Author : Vincenzo Pirrotta
language : en
Publisher: World Scientific
Release Date : 2023-07-05
Chromatin And Epigenetics An Introduction To Epigenetic Mechanisms written by Vincenzo Pirrotta and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-05 with Science categories.
This book is an introduction to epigenetics, a controversial term that denotes the mechanisms that instruct the genome on how to express the purely genetic information that encodes proteins. Starting with the discovery of repressor proteins in the 1960s, epigenetics evolved into a kind of user manual for the genetic information, telling the genome if, when, how much and in what cells to read genes. Advances in epigenetics in the past 15 years have revealed how it lies at the heart of virtually every branch of biological and medical sciences and an understanding of its basic principles is therefore essential for every student in this field.The field of chromatin and epigenetics has developed very rapidly in the past 15-20 years. The pace in the field of epigenetics has now slowed down, the basic outlines of the mechanisms and implications have solidified and a consensus has been achieved among the researchers in the field. At the same time, these mechanisms and implications are now an integral part of how we think about the genome. Genes are more than just DNA and more than just protein-coding sequences and this realization has revolutionized our understanding of the genome, gene expression and its regulation in development, health and disease. It is time, therefore, for a textbook to help train a new generation of biologists and health scientists as well as providing a basic competence among practitioners in allied fields. The present book has grown out of a course given for the past 13 years to advanced undergraduates at Rutgers University. In keeping with the experience in that course, the book is abundantly illustrated, presents a wealth of specific examples, and includes a chapter describing a number of methods and techniques that have driven the advances in the field.
Patho Epigenetics Of Disease
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Author : Janos Minarovits
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-14
Patho Epigenetics Of Disease written by Janos Minarovits and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-14 with Medical categories.
In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences. Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases.
Epigenetics In Health And Disease
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Author : Igor Kovalchuk
language : en
Publisher: FT Press
Release Date : 2012
Epigenetics In Health And Disease written by Igor Kovalchuk and has been published by FT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Juvenile Nonfiction categories.
"After reviewing the field's history and context, the authors introduce and explain each key epigenetic mechanism. Next, they extensively discuss the roles these mechanisms may play in inheritance, development, health and disease, behavior, evolution, ecology, and the interactions of individual organisms with their environments"--Page 4 of cover.
Clinical Epigenetics
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Author : Luke B. Hesson
language : en
Publisher: Springer Nature
Release Date : 2019-08-31
Clinical Epigenetics written by Luke B. Hesson and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-31 with Medical categories.
In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.
Patho Epigenetics Of Disease
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Author : Janos Minarovits
language : en
Publisher: Springer
Release Date : 2014-06-11
Patho Epigenetics Of Disease written by Janos Minarovits and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-11 with Medical categories.
In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences. Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases.
Epigenetics And Health
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Author : Michelle McCulley
language : en
Publisher: John Wiley & Sons
Release Date : 2024-04-02
Epigenetics And Health written by Michelle McCulley and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-02 with Science categories.
Epigenetics and Health An incisive and contemporary discussion of epigenetic phenomena applied to human health and disease Epigenetics and Health: A Practical Guide delivers a thorough and insightful exploration of the basic principles of gene function, gene regulation, and gene expression. The author explains how epigenetic modifications alter gene expression and demonstrate the role played by environmental factors—including nutrition, exercise, toxins, and stress—in gene regulation, as well as their potential health consequences. The book presents current methods for analyzing epigenetic variation, including NGS applications and bioinformatic analysis. Readers will be encouraged to question, analyze, and critically appraise the literature on epigenetics to further develop their understanding. They’ll also find: Explorations of epigenetic mechanisms, homeostasis, and the potential for manipulating the epigenome Practical discussions of methods for epigenetic analyses How to address cancer epigenetics, mental health epigenetics, and guidance on developing an epigenetics research project Epigenetics and Health: A Practical Guide will benefit practicing geneticists and medical geneticists seeking insights into epigenetic phenomena applied to human health and disease.
Molecular Mechanisms And Physiology Of Disease
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Author : Nilanjana Maulik
language : en
Publisher: Springer
Release Date : 2014-05-31
Molecular Mechanisms And Physiology Of Disease written by Nilanjana Maulik and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-31 with Medical categories.
In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.
Medical Epigenetics
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Author : Trygve Tollefsbol
language : en
Publisher: Academic Press
Release Date : 2016-06-21
Medical Epigenetics written by Trygve Tollefsbol and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-21 with Science categories.
Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine