Epithelial Mesenchymal Interactions In Cancer
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Epithelial Mesenchymal Interactions In Cancer
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Author : Itzhak D. Goldberg
language : en
Publisher: Birkhäuser
Release Date : 2013-03-07
Epithelial Mesenchymal Interactions In Cancer written by Itzhak D. Goldberg and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Science categories.
The contribution of epithelia-mesenchyme interaction to normal development (eg., tissue formation) and to neoplasia has become a subject of increasing interest to scientists because of recent progress in deciphering the molecular signals that mediate this interaction. Clearly, some of the same types of molecules (eg., growth factors and their receptors, proteolytic enzymes, cell adhesion molecules, and structural proteins of the extracellular matrix) mediate exchange of information between epithelia and mesenchyme during normal development and malignant growth. However, defects in the regulation of this exchange appear to contribute to malignancy by allowing growth promoting, invasogenic, and angiogenic factors to accumulate within the microenvironment of the tumor. For example, recent studies suggest that abnormal interactions between tumor epithelial cells and stromal mesenchymal cells contribute to the overproduction and accumulation of scatter factor (hepatocyte growth factor), an invasogenic and angiogenic cytokine, in certain types of tumor. The production and and activation of type IV collagenase, a matrix-degrading enzyme required for tumor cell invasion, appears to require intimate cooperation between tumor and stromal cells. The material contained in this volume highlights the state-of-the-art of knowledge of the molecular mechanisms by which epithelia and mesenchyme collaborate, and the abnormalities in these mechanisms that may lead to the development of cancer.
Epithelial Mesenchymal Interactions In Cancer
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Author : Itzhak D. Goldberg
language : en
Publisher:
Release Date : 2014-01-15
Epithelial Mesenchymal Interactions In Cancer written by Itzhak D. Goldberg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
The Epithelial To Mesenchymal Transition Emt In Cancer
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Author : Joëlle Roche
language : en
Publisher: MDPI
Release Date : 2018-04-09
The Epithelial To Mesenchymal Transition Emt In Cancer written by Joëlle Roche and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-09 with Electronic book categories.
This book is a printed edition of the Special Issue "The Epithelial-to-Mesenchymal Transition (EMT) in Cancer" that was published in Cancers
Epithelial Mesenchymal Plasticity In Cancer Metastasis
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Author : Mohit Kumar Jolly
language : en
Publisher: MDPI
Release Date : 2020-12-29
Epithelial Mesenchymal Plasticity In Cancer Metastasis written by Mohit Kumar Jolly and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-29 with Medical categories.
Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.
Recent Progress In Epithelial Mesenchymal Transitions
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Author : Donald F. Newgreen
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 2005
Recent Progress In Epithelial Mesenchymal Transitions written by Donald F. Newgreen and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Cell differentiation categories.
The concept of the epithelial-mesenchymal transition (EMT) provides a basis for understanding complex changes in gene expression, molecular function and cell behaviour. This field has undergone explosive growth in the last few years as the concept has spread from developmental biology to the pathologies of cancer and fibrosis. As scientists are on the verge of being able to control or mitigate the process of EMT in some pathological conditions, understanding of its fundamental mechanisms is of vital importance. This special issue brings together selected reviews and new data from the Boden Conference on Epithelial-Mesenchymal Transitions. The reviews highlight developmental, cancer and pathological EMTs, and are rich in detail at the cell and molecular levels. The publication is aimed at cancer biologists, pathologists and developmental biologists who are interested in why cells begin to move, and the genes and molecules involved in this process.
Rise And Fall Of Epithelial Phenotype
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Author : Pierre Savagner
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-07-05
Rise And Fall Of Epithelial Phenotype written by Pierre Savagner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-05 with Science categories.
Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT). The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.
Epithelial Mesenchymal Plasticity In Cancer Metastasis
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Author : Mohit Kumar Jolly
language : en
Publisher:
Release Date : 2020
Epithelial Mesenchymal Plasticity In Cancer Metastasis written by Mohit Kumar Jolly and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.
Epithelial Mesenchymal Transitions New Advances In Development Fibrosis And Cancer
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Author : Erik W. Thompson
language : en
Publisher:
Release Date : 2010-12-13
Epithelial Mesenchymal Transitions New Advances In Development Fibrosis And Cancer written by Erik W. Thompson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-13 with categories.
This special issue represents a progression through signaling processes, development, fibrosis and cancer, illustrating common underlying mechanisms and highlighting the growing recognition of therapeutic possibilities. Novel molecular pathways are shown in the context of known regulators, and many articles offer specific insights into therapeutic targeting. Not surprisingly, several articles relate to the signaling pathways activated by the common anchor transforming growth factor (TGF)-beta in relation to epithelial-mesenchymal transition (EMT). A number of new mechanisms with therapeutic implications are described, specifically the interplay between the non-Smad PI3 kinase-Akt-mTOR axis and EMT-associated invasion in response to TGF-beta, the unexpected role of c-Abl in repressing TGF-beta1-induced EMT, the cooperativity between oncostatin M, hepatocyte growth factor and TGF-beta1 in lung carcinoma EMT, and the roles of dystroglycan and periostin in developmental EMT associated with gastrulation and palate fusion, respectively. Collectively, the issue presents the full spectrum of interest in EMT today.
Intercellular Communication In Cancer
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Author : Mustapha Kandouz
language : en
Publisher: Springer
Release Date : 2015-11-20
Intercellular Communication In Cancer written by Mustapha Kandouz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-20 with Medical categories.
Cells are by nature compelled to live in groups. They develop dependence over signaling cues received from their microenvironment, in particular from other cells, whether of their own “kind” or of a different type. Therefore, communicating with these cells is a critical aspect of their behavior and fate, as they live and die normally or as they undergo disease-related pathological changes, with dramatic repercussions. In this book, we have asked expert researchers in the field of Intercellular Communication in Cancer to provide chapters on different aspects of interaction between neighboring cells, in the context of cancer diseases. We have specifically focused our efforts on membrane-to-membrane contact-based rather than growth factors-mediated modes of intercellular communications. The contributing authors provide an extensive overview of their respective area of specialization, with an in-depth discussion of the molecular mechanisms of cell-cell interactions, the impact on tumor progression and response to therapies, as well as the cancer diagnostic value of this scientific information. This book aims to introduce essential aspects of the normal and pathological cellular fate and homeostasis to both scientists and clinicians, and also to provide established researchers with an update on the novelties and future directions this expanding field is witnessing.
Epithelial Mesanchymal Interactions
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Author : Raul Fleischmajer (ed)
language : en
Publisher:
Release Date : 1968
Epithelial Mesanchymal Interactions written by Raul Fleischmajer (ed) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1968 with Epithelium categories.