Essential Zebrafish Methods Genetics And Genomics
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Essential Zebrafish Methods Genetics And Genomics
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Author : H. William Detrich III
language : en
Publisher: Academic Press
Release Date : 2009-09-05
Essential Zebrafish Methods Genetics And Genomics written by H. William Detrich III and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-05 with Science categories.
Due to its prolific reproduction and the external development of the transparent embryo, the zebrafish is the prime model for genetic and developmental studies, as well as research in genomics. While genetically distant from humans, nonetheless the vertebrate zebrafish has comparable organs and tissues that make it the model organism for study of vertebrate development.This book, one of two new volumes in the Reliable Lab Solutions series dealing with zebrafish, brings together a robust and up-to-date collection of time-tested methods presented by the world's leading scientists. Culled from previously published chapters in Methods in Cell Biology and updated by the original authors where relevant, it provides a comprehensive collection of protocols describing the most widely used techniques relevant to the study of zebrafish genetics and genomics. The methods in this volume were hand-selected by the editors, whose goal was to a provide a handy and cost-effective collection of fail-safe methods, tips, and "tricks of the trade" to both experienced researchers and more junior members in the lab. - Provides busy researchers a quick reference for time-tested methods and protocols that really work, updated where possible by the original authors - Gives pragmatic wisdom to the non-specialist from experts in the field with years of experience with trial and error
Essential Zebrafish Methods Cell And Developmental Biology
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Author : Monte Westerfield
language : en
Publisher: Academic Press
Release Date : 2009-08-27
Essential Zebrafish Methods Cell And Developmental Biology written by Monte Westerfield and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-27 with Science categories.
Due to its prolific reproduction and the external development of the transparent embryo, the zebrafish is the prime model for genetic and developmental studies, as well as research in genomics. While genetically distant from humans, nonetheless the vertebrate zebrafish has comparable organs and tissues that make it the model organism for study of vertebrate development.This book, one of two new volumes in the Reliable Lab Solutions series dealing with zebrafish, brings together a robust and up-to-date collection of time-tested methods presented by the world's leading scientists. Culled from previously published chapters in Methods in Cell Biology and updated by the original authors where relevant, it provides a comprehensive collection of protocols describing the most widely used techniques relevant to the study of the cellular and developmental biology of zebrafish. The methods in this volume were hand-selected by the editors, whose goal was to a provide a handy and cost-effective collection of fail-safe methods, tips, and "tricks of the trade to both experienced researchers and more junior members in the lab. - Provides busy researchers a quick reference for time-tested methods and protocols that really work, updated where possible by the original authors - Gives pragmatic wisdom to the non-specialist from experts in the field with years of experience with trial and error
A Systems Biology Approach To Advancing Adverse Outcome Pathways For Risk Assessment
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Author : Natàlia Garcia-Reyero
language : en
Publisher: Springer
Release Date : 2018-02-24
A Systems Biology Approach To Advancing Adverse Outcome Pathways For Risk Assessment written by Natàlia Garcia-Reyero and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-24 with Science categories.
Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.
The Zebrafish Genetics Genomics And Informatics
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Author :
language : en
Publisher: Elsevier
Release Date : 2004-12-30
The Zebrafish Genetics Genomics And Informatics written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12-30 with Science categories.
This volume of Methods in Cell Biology, the second of two parts on the subject of zebrafish, provides a comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 1999. This second volume covers advances in forward and reverse genetic techniques, provides an update on the zebrafish genome and gene/mutant mapping technologies, examines the new systems for efficient transgenesis in the zebrafish, provides an in-depth view of informatics and the emerging field of comparative genomics, and considers the extensive infrastructure now available to the zebrafish community.* Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls * Illustrates many techiques in full-color * Summarizes the Zebrafish Genome Project
The Zebrafish Genetics Genomics And Informatics
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Author : H. William Detrich
language : en
Publisher: Academic Press
Release Date : 2011-09-14
The Zebrafish Genetics Genomics And Informatics written by H. William Detrich and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-14 with Nature categories.
This volume on genetics, genomics, and informatics, will cover new technologies in forward and reverse genetics, transgenesis, the zebrafish genome and mapping technologies, informatics and comparative genomics, and Infrastructure. This volume of Methods in Cell Biology will prove valuable both to seasoned zebrafish investigators as well as to those who are newly adopting the zebrafish model as part of their research armamentarium.
Fish Development And Genetics The Zebrafish And Medaka Models
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Author : Zhiyuan Gong
language : en
Publisher: World Scientific
Release Date : 2004-11-02
Fish Development And Genetics The Zebrafish And Medaka Models written by Zhiyuan Gong and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-02 with Science categories.
The zebrafish is the most important fish model in developmental and genetic analyses. This book contains 19 review articles covering a broad spectrum of topics, from development to genetic tools. The contents range from early development, the role of maternal factors and gastrulation, to tissue differentiation and organogenesis, such as development of the organizer, notochord, floor plate, nervous system, somites, muscle, skeleton and endoderm. The genetic tools cover morpholino knock-down, transgenics, fish cloning, transposons and genome evolution. The book also includes two chapters on genome mapping and embryonic stem cells in medaka, another important model fish. Summarizing the state-of-the-art studies of the zebrafish model and focusing on the molecular aspects of development, this book is a valuable reference for students learning the basic aspects of the zebrafish model, and for researchers seeking resources in zebrafish research.
The Zebrafish Genetics Genomics And Transcriptomics
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-07-16
The Zebrafish Genetics Genomics And Transcriptomics written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-16 with Science categories.
The Zebrafish: Genetics, Genomics, and Transcriptomics, Fourth Edition, is the latest volume in the Methods in Cell Biology series that looks at methods for the analysis of genetics, genomics, and transcriptomics of Zebrafish. Chapters cover such topics as gene-trap mutagenesis, genetic Screens for mutations, gene editing in zebrafish, homologous gene targeting, genome-wide RNA tomography, and developmental epigenetics and the zebrafish interactome. - Covers sections on model systems and functional studies, imaging-based approaches, and emerging studies - Presents chapters written by experts in the field - Contains cutting-edge material on the topic
Sourcebook Of Models For Biomedical Research
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Author : P. Michael Conn
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-03-07
Sourcebook Of Models For Biomedical Research written by P. Michael Conn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-07 with Medical categories.
The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.
Essentials Of Laboratory Animal Science Principles And Practices
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Author : P. Nagarajan
language : en
Publisher: Springer Nature
Release Date : 2021-07-23
Essentials Of Laboratory Animal Science Principles And Practices written by P. Nagarajan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-23 with Science categories.
This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing meaningful experiments using laboratory animals.Further, the book discusses various alternatives to animal experiments for drug and chemical testing, including their advantages over the current approaches. Lastly, it examines the potential effect of harmful pathogens on the physiology of laboratory animals and discusses the state of art in in vivo imaging techniques.The book is a useful resource for research scientists, laboratory animal veterinarians, and students of laboratory animal medicine.
Zebrafish
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Author : Christiane Nusslein-Volhard
language : en
Publisher: Oxford University Press
Release Date : 2002-09-19
Zebrafish written by Christiane Nusslein-Volhard and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-19 with Science categories.
The zebrafish has become one of the most important model organisms to study biologial processes in vivo. As a vertebrate that has many of the strengths of invertebrate model systems, it offers numerous advantages to researchers interested in many aspects of embryonic development, physiology and disease. The next few years will see the completion of large scale initiatives that exploit the zebrafish as a model system for the understanding of gene function in vertebrates, including the sequencing of the genome. The zebrafish will therefore play an increasingly important role in the future of biomedical research. Whole genome sequencing projects, such as the human genome project, have led to the isolation of tens of thousands of genes for which the in vivo function is unknown. It is therefore likely that an increasing number of researchers will turn to organisms such as the zebrafish to understand the in vivo requirement for the proteins these genes encode. Recent technical advances now allow the rapid testing of in vivo function of as yet uncharacterised genes in zebrafish in large numbers and at a speed that is impossible in other systems. This book not only provides a complete set of instructions that will allow researchers to establish the zebrafish in their laboratory. It also gives a broad overview of commonly used methods and a comprehensive collection of protocols describing the most powerful techniques.