Evaluating Clinical Research
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Economic Evaluation In Clinical Trials
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Author : Henry A. Glick
language : en
Publisher: OUP Oxford
Release Date : 2014-10-02
Economic Evaluation In Clinical Trials written by Henry A. Glick and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-02 with Medical categories.
It is becoming increasingly important to examine the relationship between the outcomes of a clinical trial and the costs of the medical therapy under study. The results of such analysis can affect reimbursement decisions for new medical technologies, drugs, devices or diagnostics. It can aid companies seeking to make claims about the cost-effectiveness of their product, as well as allowing early consideration of the economic value of therapies which may be important to improving initial adoption decisions. It is also vital for addressing the requirements of regulatory bodies. Economic Evaluation in Clinical Trials provides practical advice on how to conduct cost-effectiveness analyses in controlled trials of medical therapies. This new edition has been extensively rewritten and revised; topics discussed range from design issues such as the types of services that should be measured and price weights, to assessment of quality-adjusted life years. Illustrative materials, case histories and worked examples are included to encourage the reader to apply the methods discussed. These exercises are supported with datasets, programmes and solutions made available online.
Evaluating Clinical Research
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Author : Bengt D. Furberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-15
Evaluating Clinical Research written by Bengt D. Furberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-15 with Medical categories.
This book aims to make the readers better informed and more critical consumers of clinical research. It will help the reader recognize the strengths and the weaknesses of scientific publications. In doing so, the reader will be able to distinguish patient-important and methodologically sound studies from those having limitations in design, conduct and interpretation. The text is basic and has no statistical formulas. Key take-home messages are listed at the end of each chapter. Cartoons make the text easier to read and generate a few laughs, and they underscore specific points, sometimes in a provocative way.
Understanding And Evaluating Research In Applied And Clinical Settings
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Author : George A. Morgan
language : en
Publisher: Psychology Press
Release Date : 2006-04-21
Understanding And Evaluating Research In Applied And Clinical Settings written by George A. Morgan and has been published by Psychology Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-21 with Education categories.
Clinically oriented professionals and students need to understand and evaluate the research and statistics in professional articles, especially given today's emphasis on evidence-based practice. This book demonstrates how the research approach and design help determine the appropriate statistical analysis. Understanding and Evaluating Research in Applied and Clinical Settings features: *short, independent, chapters that do not have to be read in order; *a guide to understanding why a particular statistic was selected; *an emphasis on effects sizes including measures of risk potency; *numerous cross-disciplinary examples to illustrate the material; and *methods to help determine practical and clinical significance and their relation to meta-analysis and evidence-based practice. This book is intended for practitioners and students in psychology, education, counseling, mental and allied health, nursing, and medicine, and as a text for courses on understanding research methods and statistics.
Evaluating Clinical And Public Health Interventions
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Author : Mitchell H. Katz
language : en
Publisher: Cambridge University Press
Release Date : 2010-04-29
Evaluating Clinical And Public Health Interventions written by Mitchell H. Katz and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-29 with Medical categories.
Whether you are evaluating the effectiveness of a drug, a medical device, a behavioral intervention, a community mobilization, or even a new law, this is the book for you. Written in plain language, it simplifies the process of designing interventions, analyzing the data, and publishing the results. Because the choice of research design depends on the nature of the intervention, the book covers randomized and nonrandomized designs, prospective and retrospective studies, planned clinical trials and observational studies. In addition to reviewing standard statistical analysis, the book has easy-to-follow explanations of cutting edge techniques for evaluating interventions, including propensity score analysis, instrumental variable analysis, interrupted time series analysis and sensitivity analysis. All techniques are illustrated with up-to-date examples from medical and public health literature. This will be essential reading for a wide range of healthcare professionals involved in research as well as those more specifically interested in public health issues and epidemiology.
Principles Of Scientific Literature Evaluation
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Author : Frank J. Ascione
language : en
Publisher: American Pharmacists Association (APhA)
Release Date : 2001
Principles Of Scientific Literature Evaluation written by Frank J. Ascione and has been published by American Pharmacists Association (APhA) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
This volume hinges on a structured, question-based approach to evaluating clinical drug trials, the major type of scientific study that practising pharmacists review. Growing out of the author's 20 years of teaching the subject to PharmD students, the instructional method is well established and effective. The book refines and expands upon the scientific literature evaluation section of Principles of Drug Information and Scientific Literature Evaluation (1994) a textbook co-authored by Frank J. Ascoine.
Smart Approach To Spine Clinical Research
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Author : Michael J. Lee
language : en
Publisher: Thieme
Release Date : 2013-05-29
Smart Approach To Spine Clinical Research written by Michael J. Lee and has been published by Thieme this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Medical categories.
The SMART Approach to Spine Clinical Research is a must-have guide for spine care professionals seeking to make a meaningful contribution to the scientific literature and advance their careers by publishing high-quality clinical research. Planning, conducting, and publishing the results of your clinical research can be a long and arduous journey. The SMART Approach to Spine Clinical Research presents and explains the many interrelated components essential to spine clinical research in an easily accessible way, guiding you step-by-step through the principles and methods of planning and evaluating clinical research. Also addressed are special topics such as getting your manuscript published and conducting a meta-analysis. This SMART approach provides a clear and simple road map for the planning, execution, and critical appraisal of clinical research.
Economic Evaluation In Clinical Trials
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Author : Henry A. Glick
language : en
Publisher: Handbooks in Health Economic E
Release Date : 2014-10-02
Economic Evaluation In Clinical Trials written by Henry A. Glick and has been published by Handbooks in Health Economic E this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-02 with Business & Economics categories.
It is increasingly important to examine the relationship between the outcomes of a clinical trial and the costs of the medical therapy under study. This book provides a practical guide to the techniques and issues involved in conducting economic evaluation in ongoing clinical trials, supported with examples.
Clinical Evaluation Of Medical Devices
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Author : Karen Becker Witkin
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Clinical Evaluation Of Medical Devices written by Karen Becker Witkin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Technology & Engineering categories.
The world is changing rapidly, and nowhere is this more apparent than in medicine. The standards are rapidly rising in the field of medical device trials. A few years ago, device developers would look askance if one told them that medical device trials and drug trials should have the same stan dards. Today, such a statement does not seem as outrageous, although there is still a large gap in the design of trials and number oftrials conducted for medical device and drug development programs. More than 20 years after the enactment of the US Medical Device Amendments, we can see that they served as an impetus to raise clinical trial standards for devices. Whether the data to establish the safety and efficacy of a device come from one, two, or even more clinical trials is less important in evaluating the device than whether the data are medically and scientifically support ive of its safety and efficacy. Having at least two separate studies, and at least two sites confirm results, adds a great deal of scientific credibility and support to a conclusion of safety and efficacy, even though a confirmatory trial is not yet a regulatory requirement in most countries.
The Prevention And Treatment Of Missing Data In Clinical Trials
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2010-12-21
The Prevention And Treatment Of Missing Data In Clinical Trials written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-21 with Medical categories.
Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Smart Approach To Spine Clinical Research
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Author : Michael J. Lee
language : en
Publisher: Thieme
Release Date : 2013-05-29
Smart Approach To Spine Clinical Research written by Michael J. Lee and has been published by Thieme this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Medical categories.
The SMART Approach to Spine Clinical Research is a must-have guide for spine care professionals seeking to make a meaningful contribution to the scientific literature and advance their careers by publishing high-quality clinical research. Planning, conducting, and publishing the results of your clinical research can be a long and arduous journey. The SMART Approach to Spine Clinical Research presents and explains the many interrelated components essential to spine clinical research in an easily accessible way, guiding you step-by-step through the principles and methods of planning and evaluating clinical research. With a special focus on bias reduction and spine-related case examples, this SMART approach represents those essential components: Study question Searching the literature Study design Measurements Analysis Resources and funding Timing Also addressed in the book are special topics such as getting your manuscript published and conducting a meta-analysis. This SMART approach provides a clear and simple road map for the planning, execution, and critical appraisal of clinical research.