Evolution Of 3d Chromatin Architecture
DOWNLOAD
Download Evolution Of 3d Chromatin Architecture PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Evolution Of 3d Chromatin Architecture book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Evolution Of 3d Chromatin Architecture
DOWNLOAD
Author : Liene Astica
language : en
Publisher:
Release Date : 2023*
Evolution Of 3d Chromatin Architecture written by Liene Astica and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023* with categories.
Englische Version: The three-dimensional organization of animal genomes, known as topologically associating domains (TADs), is crucial for controlling gene activity. TADs are regions with increased genetic interactions, separated by zones with fewer contacts. In vertebrates, the formation of TADs involves a dynamic process called loop extrusion, where cohesin and CTCFs bind to the chromatin. This process creates chromatin loops, with cohesin complexes pausing when they encounter CTCF molecules in a specific orientation. However, although CTCF is highly conserved among bilaterian species, its vital role in organizing genomes spatially has not been observed in invertebrates like flies. This study investigates the chromatin structure in Ciona robusta, a chordate species situated evolutionarily between well-studied organisms like mice and fruit flies. A unique approach was developed to explore the evolution of CTCF as a mediator of three-dimensional chromatin organization. By swapping CTCF orthologs from representative species across the bilaterian group, the research examined their impact on viability, traits, gene expression, genome architecture, and binding patterns across the genome. The findings indicate that Ciona robusta, a non-vertebrate chordate, lacks typical TAD structures, even in the presence of CTCF. However, although the Ciona ortholog cannot create TADs in mouse embryonic stem cells, it can act as a transcription factor, restoring the expression of specific genes and viability in cases of complete CTCF loss. This suggests that CTCF serves a conserved role as a transcription regulator, beyond its recognized role as a structural component in some species. Furthermore, when the mouse ortholog of CTCF was introduced into the fruit fly genome, it failed to induce the formation of chromatin loops, suggesting that the vertebrate version of CTCF alone is insufficient for effective loop extrusion. [...].
Chromatin Architecture
DOWNLOAD
Author : Kirti Prakash
language : en
Publisher: Springer
Release Date : 2017-02-20
Chromatin Architecture written by Kirti Prakash and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-20 with Science categories.
This book sheds new light on the current state of knowledge concerning chromatin organization. Particular emphasis is given to the new imaging potential offered by super-resolution microscopy, which allows DNA imaging with a very high labeling density. From the early work on chromosomes by Walther Flemming in the nineteenth century to recent advances in genomics, the history of chromatin research now spans more than a century. The various milestones, such as the discovery of the double helix structure, the sequencing of the human genome, and the recent description of the genome in 3D space, show that understanding chromatin and chromosome function requires a clear understanding of its structure. Presenting cutting-edge data from super-resolution single molecule microscopy, the book demonstrates that chromatin manifests several levels of folding, from nucleosomes to chromosomes. Chromatin domains emerge as a new fundamental building block of chromatin architecture, with functions possibly related to gene regulation. A detailed description of chromatin folding in the pachytene stage of meiosis serves as a model for exploring this functionality, showing the apparent interplay between structure, function, and epigenetic regulation. Lastly, the book discusses possible new avenues of innovation to describe chromatin’s organization and functions. Gathering essential insights on chromatin architecture, the book offers students an introduction to microscopy and its application to chromatin organization, while also providing advanced readers with new ideas for future research.
Modeling The 3d Conformation Of Genomes
DOWNLOAD
Author : Guido Tiana
language : en
Publisher: CRC Press
Release Date : 2019-01-15
Modeling The 3d Conformation Of Genomes written by Guido Tiana and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-15 with Science categories.
This book provides a timely summary of physical modeling approaches applied to biological datasets that describe conformational properties of chromosomes in the cell nucleus. Chapters explain how to convert raw experimental data into 3D conformations, and how to use models to better understand biophysical mechanisms that control chromosome conformation. The coverage ranges from introductory chapters to modeling aspects related to polymer physics, and data-driven models for genomic domains, the entire human genome, epigenome folding, chromosome structure and dynamics, and predicting 3D genome structure.
New Approaches In Chordate And Vertebrate Evolution And Development
DOWNLOAD
Author : Juan Pascual-Anaya
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-05
New Approaches In Chordate And Vertebrate Evolution And Development written by Juan Pascual-Anaya and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-05 with Science categories.
Old Questions And Young Approaches To Animal Evolution
DOWNLOAD
Author : José M. Martín-Durán
language : en
Publisher: Springer
Release Date : 2019-07-22
Old Questions And Young Approaches To Animal Evolution written by José M. Martín-Durán and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-22 with Science categories.
Animal evolution has always been at the core of Biology, but even today many fundamental questions remain open. The field of animal ‘evo-devo’ is leveraging recent technical and conceptual advances in development, paleontology, genomics and transcriptomics to propose radically different answers to traditional evolutionary controversies. This book is divided into four parts, each of which approaches animal evolution from a different perspective. The first part (chapters 2 and 3) investigates how new sources of evidence have changed conventional views of animal origins, while the second (chapters 4–8) addresses the connection between embryogenesis and evolution, and the genesis of cellular, tissue and morphological diversity. The third part (chapters 9 and 10) investigates how big data in molecular biology is transforming our understanding of the mechanisms governing morphological change in animals. In closing, the fourth part (chapters 11–13) explores new theoretical and conceptual approaches to animal evolution. ‘Old questions and young approaches to animal evolution’ offers a comprehensive and updated view of animal evolutionary biology that will serve both as a first step into this fascinating field for students and university educators, and as a review of complementary approaches for researchers.
Mechanisms Driving Karyotype Evolution And Genomic Architecture
DOWNLOAD
Author : Aurora Ruiz-Herrera
language : en
Publisher: MDPI
Release Date : 2021-08-31
Mechanisms Driving Karyotype Evolution And Genomic Architecture written by Aurora Ruiz-Herrera and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-31 with Science categories.
Understanding of the origin of species and their adaptability to new environments is one of the main questions in biology. This is fueled by the ongoing debate on species concepts and facilitated by the availability of an unprecedented large number of genomic resources. Genomes are organized into chromosomes, where significant variations in number and morphology are observed among species due to large-scale structural variants such as inversions, translocations, fusions, and fissions. This genomic reshuffling provides, in the long term, new chromosomal forms on which natural selection can act upon, contributing to the origin of biodiversity. This book contains mainly articles, reviews, and an opinion piece that explore numerous aspects of genome plasticity among taxa that will help in understanding the dynamics of genome composition, the evolutionary relationships between species and, in the long run, speciation.
Hayes Principles And Methods Of Toxicology
DOWNLOAD
Author : A. Wallace Hayes
language : en
Publisher: CRC Press
Release Date : 2023-07-03
Hayes Principles And Methods Of Toxicology written by A. Wallace Hayes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-03 with Medical categories.
Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.
Epigenetic Processes And Evolution Of Life
DOWNLOAD
Author : Jana Švorcová
language : en
Publisher: CRC Press
Release Date : 2019-01-15
Epigenetic Processes And Evolution Of Life written by Jana Švorcová and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-15 with Science categories.
The book covers the possible story of emergence of life and its subsequent evolution, emphasizing the necessary evolutionary step negotiation of a common "language set" which kept all inhabitants in the biosphere together, ensuring a basic level of understanding among them. The book focuses on "protocols of communication" (both genetic and epigenetic) representing norms shared and understood across the whole biosphere, enabling a plethora of holobiotic relationships. Cooperative nature of organismal evolution and epigenetic processes as a major force in evolution are also covered. Topics discussed are illustrated in detail on selected casuistics.
Chromatin Regulation And Dynamics
DOWNLOAD
Author : Anita Göndör
language : en
Publisher: Academic Press
Release Date : 2016-10-25
Chromatin Regulation And Dynamics written by Anita Göndör and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-25 with Science categories.
Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes
The Role Of High Order Chromatin Organization In Gene Regulation
DOWNLOAD
Author : Alexey V. Pindyurin
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-11
The Role Of High Order Chromatin Organization In Gene Regulation written by Alexey V. Pindyurin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-11 with Science categories.