Evolution Of Protein Molecules
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Evolution Of Protein Molecules
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Author : Hiroshi Matsubara
language : en
Publisher:
Release Date : 1978
Evolution Of Protein Molecules written by Hiroshi Matsubara and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Evolution (Biology) categories.
Evolution Of Protein Molecule
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Author : International Specialized Book Services
language : en
Publisher:
Release Date : 1978-06-01
Evolution Of Protein Molecule written by International Specialized Book Services and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978-06-01 with categories.
Protein Evolution
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Author : Laszlo Patthy
language : en
Publisher: John Wiley & Sons
Release Date : 2009-03-12
Protein Evolution written by Laszlo Patthy and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-12 with Science categories.
This book provides an up-to-date summary of the principles of protein evolution and discusses both the methods available to analyze the evolutionary history of proteins as well as those for predicting their structure-function relationships. Includes a significantly expanded chapter on genome evolution to cover genomes of model organisms sequenced since the completion of the first edition, and organelle genome evolution Retains its reader-friendly, accessible style and organization Contains an updated glossary and new references, including a list of online reference sites
Mammalian Protein Metabolism
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Author : H.N. MUNRO (ed)
language : en
Publisher:
Release Date : 1969
Mammalian Protein Metabolism written by H.N. MUNRO (ed) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1969 with categories.
Protein metabolism during evolution and development of mammals; An introduction to protein metabolism during the evolution and development of mammals; Evolution of protein molecules; Evolution of protein metabolism in mammals; Protein metabolism during growth and development; A general survey of techniques used in studying protein metabolism in whole animals and intact cells; Application of computers to the study of protein metabolism; The assessment of protein nutrition and metabolism in the whole animal, with special reference to man; Methodology of protein evalution; Analysis of tissues and body fluids for nutrigenous constituents.
Mammalian Protein Metabolism
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Author : H.N. Munro
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Mammalian Protein Metabolism written by H.N. Munro and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Mammalian Protein Metabolism, Volume IV is an 11-chapter text that describes the regulation of protein metabolism in mammals, both at the subcellular level and at the level of the intact organ and of the whole animal. The first two chapters deal with the fundamental control mechanisms in the synthesis and turnover of proteins, followed by chapters on the mode of action of hormones on protein metabolism and on the role of free amino acid pools in regulation. These topics are followed by discussions on the regulation of individual amino acid pathways and the diurnal rhythms in protein metabolism. The final chapters explore the regulation of protein metabolism in four major organs and tissues of the body, including the gastrointestinal tract, liver, kidney, and musculature. This book will be of great benefit to biologists, researchers, and biology students.
Molecular Evolution On Rugged Landscapes
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Author : Alan S. Perelson
language : en
Publisher: CRC Press
Release Date : 2018-03-08
Molecular Evolution On Rugged Landscapes written by Alan S. Perelson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-08 with Science categories.
This book lays out a number of the general issues concerning the structure of rugged fitness landscapes and examines both the history and the current status of experimental work on somatic mutation and the maturation of the immune response.
On Protein Structure Function And Modularity From An Evolutionary Perspective
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Author : Robert Pilstål
language : en
Publisher: Linköping University Electronic Press
Release Date : 2018-05-31
On Protein Structure Function And Modularity From An Evolutionary Perspective written by Robert Pilstål and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-31 with categories.
We are compounded entities, given life by a complex molecular machinery. When studying these molecules we have to make sense of a diverse set of dynamical nanostructures with wast and intricate patterns of interactions. Protein polymers is one of the major groups of building blocks of such nanostructures which fold up into more or less distinct three dimensional structures. Due to their shape, dynamics and chemical properties proteins are able to perform a plethora of specific functions essential to all known cellular lifeforms. The connection between protein sequence, translated into protein structure and in the continuation into protein function is well accepted but poorly understood. Malfunction in the process of protein folding is known to be implicated in natural aging, cancer and degenerative diseases such as Alzheimer's. Protein folds are described hierarchically by structural ontologies such as SCOP, CATH and Pfam all which has yet to succeed in deciphering the natural language of protein function. These paradigmatic views centered on protein structure fail to describe more mutable entities, such as intrinsically disordered proteins (IDPs) which lack a clear defined structure. As of 2012, about two thirds of cancer patients was predicted to survive past 5 years of diagnosis. Despite this, about a third do not survive and numerous of successfully treated patients suffer from secondary conditions due to chemotherapy, surgery and the like. In order to handle cancer more efficiently we have to better understand the underlying molecular mechanisms. Elusive to standard methods of investigation, IDPs have a central role in pathology; dysfunction in IDPs are key factors in cellular system failures such as cancer, as many IDPs are hub regulators for major cell functions. These IDPs carry short conserved functional boxes, that are not described by known ontologies, which suggests the existence of a smaller entity. In an investigation of a pair of such boxes of c-MYC, a plausible structural model of its interacting with Pin1 emerged, but such a model still leaves the observer with a puzzle of understanding the actual function of that interaction. If the protein is represented as a graph and modeled as the interaction patterns instead of as a structural entity, another picture emerges. As a graph, there is a parable from that of the boxes of IDPs, to that of sectors of allosterically connected residues and the theory of foldons and folding units. Such a description is also useful in deciphering the implications of specific mutations. In order to render a functional description feasible for both structured and disordered proteins, there is a need of a model separate from form and structure. Realized as protein primes, patterns of interaction, which has a specific function that can be defined as prime interactions and context. With function defined as interactions, it might be possible that the discussion of proteins and their mechanisms is thereby simplified to the point rendering protein structural determination merely supplementary to understanding protein function. Människan byggs upp av celler, de i sin tur består av än mindre beståndsdelar; livets molekyler. Dessa fungerar som mekaniska byggstenar, likt maskiner och robotar som sliter vid fabrikens band; envar utförandes en absolut nödvändig funktion för cellens, och hela kroppens, fortsatta överlevnad. De av livets molekyler som beskrivs centralt i den här avhandling är proteiner, vilka i sin tur består utav en lång kedja, med olika typer av länkar, som likt garn lindar upp sig i ett nystan av en (mer eller mindre...) bestämd struktur som avgör dess roll och funktion i cellen. Intrinsiellt oordnade proteiner (IDP) går emot denna enkla åskådning; de är proteiner som saknar struktur och beter sig mer likt spaghetti i vatten än en maskin. IDP är ändå funktionella och bär på centrala roller i cellens maskineri; exempel är oncoproteinet c-Myc som agerar "gaspedal" för cellen - fel i c-Myc's funktion leder till att cellerna löper amok, delar sig hejdlöst och vi får cancer. Man har upptäckt att c-Myc har en ombytlig struktur vi inte kan se; studier av punktvisa förändringar, mutationer, i kedjan av byggstenar hos c-Myc visar att många länkar har viktiga roller i funktionen. Detta ger oss bättre förståelse om cancer men samtidigt är laboratoriearbetet både komplicerat och dyrt; här kan evolutionen vägleda oss och avslöja hemligheterna snabbare. Molekylär evolution studeras genom att beräkna variation i proteinkedjan mellan besläktade arter som finns lagrade i databaser; detta visar snabbt, via nätverksanalys och grafteori, vilka delar av proteinet som är centrala och kopplade till varandra av nödvändighet för artens fortlevnad. På så vis hjälper evolutionen oss att förstå proteinfunktioner via modeller baserade på proteinernas interaktioner snarare än deras struktur. Samma modeller kan nyttjas för att förstå dynamiska förlopp och skillnader mellan normala och patologiska varianter av proteiner; mutationer kan uppstå i vår arvsmassa som kan leda till sjukdom. Genom analys av proteinernas kopplingsnätverk i grafmodellerna kan man bättre förutsäga vilka mutationer som är farligare än andra. Dessutom har det visat sig att en sådan representation kan ge bättre förståelse för den normala funktionen hos ett protein än vad en proteinstruktur kan. Här introduceras även konceptet proteinprimärer, vilket är en abstrakt representation av proteiner centrerad på deras interaktiva mönster, snarare än på partikulär form och struktur. Det är en förhoppning att en sådan representation skall förenkla diskussionen anbelangande proteinfunktion så till den grad att strukturbestämmelse av proteiner, som är en mycket kostsam och tidskrävande process, till viss mån kan anses vara sekundär i betydelse jämfört med funktionellt modellerande baserat på evolutionära data extraherade ur våra sekvensdatabaser.
The Molecules Of Life
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Author : Russ Hodge
language : en
Publisher: Infobase Publishing
Release Date : 2009
The Molecules Of Life written by Russ Hodge and has been published by Infobase Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Biochemistry categories.
Computational Methods In Protein Evolution
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Author : Tobias Sikosek
language : en
Publisher:
Release Date : 2019
Computational Methods In Protein Evolution written by Tobias Sikosek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Protein engineering categories.
Structural Approaches To Sequence Evolution
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Author : Ugo Bastolla
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-26
Structural Approaches To Sequence Evolution written by Ugo Bastolla and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-26 with Science categories.
Recent advances in understanding the thermodynamics of macromolecules, the topological properties of gene networks, the organization and mutation capabilities of genomes, and the structure of populations make it possible to incorporate these key elements into a broader and deeply interdisciplinary view of molecular evolution. This book gives an account of such a new approach, through clear tutorial contributions by leading scientists.