Experimental And Computational Approaches To Engineer Microbial Metabolism
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Experimental And Computational Approaches To Engineer Microbial Metabolism
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Author : Paul Alexander Adamczyk
language : en
Publisher:
Release Date : 2019
Experimental And Computational Approaches To Engineer Microbial Metabolism written by Paul Alexander Adamczyk and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
In this thesis, I have demonstrated the utility and benefits of using both computational and experimental approaches to engineer metabolism. Specifically, I have shown that metabolic flux analysis with labeled tracers is a powerful tool to accurately estimate in vivo fluxes. Using this tool, I have successfully estimated the in vivo thermodynamics and fluxes of both wild-type and 8b Z. mobilis, information that can then be integrated with additional multi-omics datasets to generate a kinetic model of Z. mobilis metabolism. Furthermore, the concept of kinetic modeling is promising; however, advancements in user-friendly computational tools to minimize the amount of data needed to fully parameterize any given kinetic model are needed, as collecting high-quality, multi-omics datasets is the rate-limiting step toward more published kinetic models in the literature. Additionally, this thesis demonstrates how rational metabolic engineering approaches can be applied to produce an industrially relevant chemical, valine, starting from a precursor-abundant platform strain at the highest yields in E. coli reported in the literature. Lastly, it is demonstrated that an active learning algorithm, ActiveOpt, is capable of leading metabolic engineers to superior strains faster than rational approaches alone. In the near future, more user-friendly computational tools (e.g., ActiveOpt) will be needed to assist metabolic engineers-especially those who don't have access to high throughput capabilities-in generating superior strains, that produce renewable bioproducts, faster than traditional methods, to meet increasing demands for a sustainable future.
Fluxomics And Metabolic Analysis In Systems Microbiology
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Author : Wei Xiong
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-21
Fluxomics And Metabolic Analysis In Systems Microbiology written by Wei Xiong and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-21 with categories.
Metabolic Pathway Engineering
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Author : Jean F. Challacombe
language : en
Publisher: CRC Press
Release Date : 2021-07-14
Metabolic Pathway Engineering written by Jean F. Challacombe and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-14 with Medical categories.
Metabolic systems engineering combines the tools and approaches of systems biology, synthetic biology, and evolutionary engineering. This book reviews studies on metabolism, from the earliest work of Lavoisier and Buchner to current cutting-edge research in metabolic systems engineering. This technology has been used in bioengineering applications to create high-performing microbes and plants that produce important chemicals, pharmaceuticals, crops, and other natural products. Current applications include optimizing metabolic pathways to enhance degradation of biomass for biofuel production and accelerated processing of environmental waste products and contaminants. The book includes examples to illustrate the applications of this technology in the optimization of metabolic pathways to create robust industrial strains as well as in the engineering of biological processes involving health and diseases of humans, animals, and plants. Written by a seasoned computational biologist with many years of experience in genomics, bioinformatics, and systems biology, this book will appeal to anyone interested in metabolic systems analysis and metabolic pathway engineering.
Microbes Based Approaches For The Management Of Hazardous Contaminants
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Author : Ajay Kumar
language : en
Publisher: John Wiley & Sons
Release Date : 2024-07-08
Microbes Based Approaches For The Management Of Hazardous Contaminants written by Ajay Kumar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-08 with Science categories.
Learn the various microbiological aspects one deals with in environment management and the remediation of toxic contaminants in the environment In recent years, the accumulation of hazardous contaminants has caused a broad-based deterioration in global environmental quality. These have had wide-ranging negative social impacts, affecting climate, soil and water ecosystems, and more. As traditional methods of contaminant mitigation have proven inadequate to the task, microbial-based remediation offers the clearest, most environmentally friendly path forward for this crucial aspect of global environmental stewardship. Microbes Based Approaches for the Management of Hazardous Contaminants offers comprehensive coverage of novel and indigenous microbes and their applications in contaminant mitigation. Surveying all the major microbial products and methods for degrading and remediating hazardous pollutants, it offers a key tool in the fight against global environmental degradation. The result is a cutting-edge introduction to an essential subject. Microbes Based Approaches for the Management of Hazardous Contaminants will also find: Current and future approaches to microbial degradation Detailed discussion of biofilms, exopolysaccharides, enzymes, metabolites, and many more Coverage of metabolic engineering as an alternative strategy Microbes Based Approaches for the Management of Hazardous Contaminants is ideal for those working in the field for the application of microbes in the remediation of hazardous pollutants and environment management, particularly those interested in environmental sciences, microbiology and microbial technology, environmental biotechnology, and molecular biology.
Metabolic Engineering
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Author : Sang Yup Lee
language : en
Publisher: John Wiley & Sons
Release Date : 2021-06-02
Metabolic Engineering written by Sang Yup Lee and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-02 with Science categories.
Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.
Synthetic Biology And Metabolic Engineering In Plants And Microbes Part A Metabolism In Microbes
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-07-11
Synthetic Biology And Metabolic Engineering In Plants And Microbes Part A Metabolism In Microbes written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-11 with Science categories.
Synthetic Biology and Metabolic Engineering in Plants and Microbes: Part A, the new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods, synthetic biology, and metabolic engineering in plants and microbes, and includes sections on such topics as the uses of integrases in microbial engineering, biosynthesis, and engineering of tryptophan derived metabolites, regulation and discovery of fungal natural products, and elucidation and localization of plant pathways. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Contains two volumes covering research methods in synthetic biology and metabolic engineering in plants and microbes - Presents sections on such topics as the uses of integrases in microbial engineering, biosynthesis, and engineering of tryptophan derived metabolites, regulation and discovery of fungal natural products, and elucidation and localization of plant pathways
Systems And Synthetic Metabolic Engineering
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Author : Yanfeng Liu
language : en
Publisher: Academic Press
Release Date : 2020-07-10
Systems And Synthetic Metabolic Engineering written by Yanfeng Liu and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-10 with Science categories.
Systems and Synthetic Metabolic Engineering provides an overview of the development of metabolic engineering within medicine that is fueled by systems and synthetic biology. These newly developed, successful strategies of metabolic engineering guide the audience on how to propose and test proper strategies for metabolic engineering research. In addition to introductory, regulatory and challenges in the field, the book also covers dynamic control and autonomous regulation to control cell metabolism, along with computational modeling and industrial applications. The book is written by leaders in the field, making it ideal for synthetic biologists, researchers, students and anyone working in this area. - Discusses the current progress of metabolic engineering, focusing on systems biology and synthetic biology - Covers introductory, regulatory, strategies, production and challenges in the field - Written technically for synthetic biologists, researchers, students, industrialists, policymakers and stakeholders
The Metabolic Pathway Engineering Handbook
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Author : Christina Smolke
language : en
Publisher: CRC Press
Release Date : 2009-07-28
The Metabolic Pathway Engineering Handbook written by Christina Smolke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-28 with Medical categories.
This first volume of the Metabolic Pathway Engineering Handbook provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction
Introduction To Metabolic And Cellular Engineering An Second Edition
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Author : Sonia Del Carmen Cortassa
language : en
Publisher: World Scientific
Release Date : 2011-12-28
Introduction To Metabolic And Cellular Engineering An Second Edition written by Sonia Del Carmen Cortassa and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-28 with Technology & Engineering categories.
Metabolic and Cellular Engineering (MCE) is more than an exciting scientific enterprise. It has become the cornerstone for coping with the challenges ahead of mankind. Continuous developments, new concepts, and technological innovations will enable us to deal with emerging challenges, and solve problems once thought impossible ten years ago. Challenges in MCE are broad- from unraveling fundamental aspects of cellular function to meeting unsatiated energy and food demands that are rising in parallel with population growth.In charting the progress of MCE during the last decade, we could not help but feel in awe of the enormous strides of progress made from the nascent Metabolic Engineering to the Systems Bioengineering of today. The burgeoning availability of genomic sequences from diverse species has been spectacular. It has become the engine that drives the genetic means for the modification of existing organisms and the generation of synthetic, man-made ones. From the initial attempts at purposeful genetic modification of a cell for the production of valuable compounds, we have now moved on to changing microbes genetically or metabolically.The arsenal of experimental and theoretical tools available for Metabolic and Cellular Engineering has expanded enormously, driven by the re-emergence of Physiology as Systems Biology. The revival of the concept of networks fueled by new developments has become central to Systems Biology. Networks represent an integrative vision of how processes of disparate nature relate to each other, and as such is becoming a key analytical and conceptual tool for MCE. This book reflects and addresses all these ongoing changes while providing the essential conceptual and analytical tools needed to understand and work in the MCE research field.
Engineering The Microbial Platform For The Production Of Biologics And Small Molecule Medicines
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Author : Dipesh Dhakal
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-23
Engineering The Microbial Platform For The Production Of Biologics And Small Molecule Medicines written by Dipesh Dhakal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-23 with categories.