Exploration And Analysis Of Dna Microarray And Protein Array Data
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Exploration And Analysis Of Dna Microarray And Protein Array Data
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Author : Dhammika Amaratunga
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-25
Exploration And Analysis Of Dna Microarray And Protein Array Data written by Dhammika Amaratunga and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-25 with Mathematics categories.
A cutting-edge guide to the analysis of DNA microarray data Genomics is one of the major scientific revolutions of this century, and the use of microarrays to rapidly analyze numerous DNA samples has enabled scientists to make sense of mountains of genomic data through statistical analysis. Today, microarrays are being used in biomedical research to study such vital areas as a drug’s therapeutic value–or toxicity–and cancer-spreading patterns of gene activity. Exploration and Analysis of DNA Microarray and Protein Array Data answers the need for a comprehensive, cutting-edge overview of this important and emerging field. The authors, seasoned researchers with extensive experience in both industry and academia, effectively outline all phases of this revolutionary analytical technique, from the preprocessing to the analysis stage. Highlights of the text include: A review of basic molecular biology, followed by an introduction to microarrays and their preparation Chapters on processing scanned images and preprocessing microarray data Methods for identifying differentially expressed genes in comparative microarray experiments Discussions of gene and sample clustering and class prediction Extension of analysis methods to protein array data Numerous exercises for self-study as well as data sets and a useful collection of computational tools on the authors’ Web site make this important text a valuable resource for both students and professionals in the field.
Exploration And Analysis Of Dna Microarray And Other High Dimensional Data
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Author : Dhammika Amaratunga
language : en
Publisher: John Wiley & Sons
Release Date : 2014-01-27
Exploration And Analysis Of Dna Microarray And Other High Dimensional Data written by Dhammika Amaratunga and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-27 with Mathematics categories.
Praise for the First Edition “...extremely well written...a comprehensive and up-to-date overview of this important field.” – Journal of Environmental Quality Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition provides comprehensive coverage of recent advancements in microarray data analysis. A cutting-edge guide, the Second Edition demonstrates various methodologies for analyzing data in biomedical research and offers an overview of the modern techniques used in microarray technology to study patterns of gene activity. The new edition answers the need for an efficient outline of all phases of this revolutionary analytical technique, from preprocessing to the analysis stage. Utilizing research and experience from highly-qualified authors in fields of data analysis, Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition features: A new chapter on the interpretation of findings that includes a discussion of signatures and material on gene set analysis, including network analysis New topics of coverage including ABC clustering, biclustering, partial least squares, penalized methods, ensemble methods, and enriched ensemble methods Updated exercises to deepen knowledge of the presented material and provide readers with resources for further study The book is an ideal reference for scientists in biomedical and genomics research fields who analyze DNA microarrays and protein array data, as well as statisticians and bioinformatics practitioners. Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition is also a useful text for graduate-level courses on statistics, computational biology, and bioinformatics.
Dna Microarrays And Gene Expression
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Author : Pierre Baldi
language : en
Publisher:
Release Date : 2002
Dna Microarrays And Gene Expression written by Pierre Baldi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with DNA microarrays categories.
DNA microarrays are revolutionizing biology and medicine. They can provide a snapshot of the level of gene expression in a cell and are therefore a powerful tool with which to study biological phenomena at the molecular level. This inter-disciplinary introduction will be essential reading for researchers of all disciplines.
Multistate Systems Reliability Theory With Applications
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Author : Bent Natvig
language : en
Publisher: John Wiley & Sons
Release Date : 2010-12-07
Multistate Systems Reliability Theory With Applications written by Bent Natvig and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-07 with Mathematics categories.
Most books in reliability theory are dealing with a description of component and system states as binary: functioning or failed. However, many systems are composed of multi-state components with different performance levels and several failure modes. There is a great need in a series of applications to have a more refined description of these states, for instance, the amount of power generated by an electrical power generation system or the amount of gas that can be delivered through an offshore gas pipeline network. This book provides a descriptive account of various types of multistate system, bound-for multistate systems, probabilistic modeling of monitoring and maintenance of multistate systems with components along with examples of applications. Key Features: Looks at modern multistate reliability theory with applications covering a refined description of components and system states. Presents new research, such as Bayesian assessment of system availabilities and measures of component importance. Complements the methodological description with two substantial case studies. Reliability engineers and students involved in the field of reliability, applied mathematics and probability theory will benefit from this book.
Applied Linear Regression
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Author : Sanford Weisberg
language : en
Publisher: John Wiley & Sons
Release Date : 2013-06-07
Applied Linear Regression written by Sanford Weisberg and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-07 with Mathematics categories.
Master linear regression techniques with a new edition of a classic text Reviews of the Second Edition: "I found it enjoyable reading and so full of interesting material that even the well-informed reader will probably find something new . . . a necessity for all of those who do linear regression." —Technometrics, February 1987 "Overall, I feel that the book is a valuable addition to the now considerable list of texts on applied linear regression. It should be a strong contender as the leading text for a first serious course in regression analysis." —American Scientist, May–June 1987 Applied Linear Regression, Third Edition has been thoroughly updated to help students master the theory and applications of linear regression modeling. Focusing on model building, assessing fit and reliability, and drawing conclusions, the text demonstrates how to develop estimation, confidence, and testing procedures primarily through the use of least squares regression. To facilitate quick learning, the Third Edition stresses the use of graphical methods in an effort to find appropriate models and to better understand them. In that spirit, most analyses and homework problems use graphs for the discovery of structure as well as for the summarization of results. The Third Edition incorporates new material reflecting the latest advances, including: Use of smoothers to summarize a scatterplot Box-Cox and graphical methods for selecting transformations Use of the delta method for inference about complex combinations of parameters Computationally intensive methods and simulation, including the bootstrap method Expanded chapters on nonlinear and logistic regression Completely revised chapters on multiple regression, diagnostics, and generalizations of regression Readers will also find helpful pedagogical tools and learning aids, including: More than 100 exercises, most based on interesting real-world data Web primers demonstrating how to use standard statistical packages, including R, S-Plus®, SPSS®, SAS®, and JMP®, to work all the examples and exercises in the text A free online library for R and S-Plus that makes the methods discussed in the book easy to use With its focus on graphical methods and analysis, coupled with many practical examples and exercises, this is an excellent textbook for upper-level undergraduates and graduate students, who will quickly learn how to use linear regression analysis techniques to solve and gain insight into real-life problems.
Robust Statistics
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Author : Frank R. Hampel
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-20
Robust Statistics written by Frank R. Hampel and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-20 with Mathematics categories.
The Wiley-Interscience Paperback Series consists of selectedbooks that have been made more accessible to consumers in an effortto increase global appeal and general circulation. With these newunabridged softcover volumes, Wiley hopes to extend the lives ofthese works by making them available to future generations ofstatisticians, mathematicians, and scientists. "This is a nice book containing a wealth of information, much ofit due to the authors. . . . If an instructor designing such acourse wanted a textbook, this book would be the best choiceavailable. . . . There are many stimulating exercises, and the bookalso contains an excellent index and an extensive list ofreferences." —Technometrics "[This] book should be read carefully by anyone who isinterested in dealing with statistical models in a realisticfashion." —American Scientist Introducing concepts, theory, and applications, RobustStatistics is accessible to a broad audience, avoidingallusions to high-powered mathematics while emphasizing ideas,heuristics, and background. The text covers the approach based onthe influence function (the effect of an outlier on an estimater,for example) and related notions such as the breakdown point. Italso treats the change-of-variance function, fundamental conceptsand results in the framework of estimation of a single parameter,and applications to estimation of covariance matrices andregression parameters.
Combinatorial Methods In Discrete Distributions
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Author : Charalambos A. Charalambides
language : en
Publisher: John Wiley & Sons
Release Date : 2005-06-24
Combinatorial Methods In Discrete Distributions written by Charalambos A. Charalambides and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-24 with Mathematics categories.
A unique approach illustrating discrete distribution theory through combinatorial methods This book provides a unique approach by presenting combinatorial methods in tandem with discrete distribution theory. This method, particular to discreteness, allows readers to gain a deeper understanding of theory by using applications to solve problems. The author makes extensive use of the reduction approach to conditional distributions of independent random occupancy numbers, and provides excellent studies of occupancy and sequential occupancy distributions, convolutions of truncated discrete distributions, and compound and mixture distributions. Combinatorial Methods in Discrete Distributions begins with a brief presentation of set theory followed by basic counting principles. Fundamental principles of combinatorics, finite differences, and discrete probability are included to give readers the necessary foundation to the topics presented in the text. A thorough examination of the field is provided and features: Stirling numbers and generalized factorial coefficients Occupancy and sequential occupancy distributions n-fold convolutions of truncated distributions Compound and mixture distributions Thoroughly worked examples aid readers in understanding complex theory and discovering how theory can be applied to solve practical problems. An appendix with hints and answers to the exercises helps readers work through the more complex sections. Reference notes are provided at the end of each chapter, and an extensive bibliography offers readers a resource for additional information on specialized topics.
Statistics For Imaging Optics And Photonics
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Author : Peter Bajorski
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-26
Statistics For Imaging Optics And Photonics written by Peter Bajorski and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-26 with Mathematics categories.
A vivid, hands-on discussion of the statistical methods in imaging, optics, and photonics applications In the field of imaging science, there is a growing need for students and practitioners to be equipped with the necessary knowledge and tools to carry out quantitative analysis of data. Providing a self-contained approach that is not too heavily statistical in nature, Statistics for Imaging, Optics, and Photonics presents necessary analytical techniques in the context of real examples from various areas within the field, including remote sensing, color science, printing, and astronomy. Bridging the gap between imaging, optics, photonics, and statistical data analysis, the author uniquely concentrates on statistical inference, providing a wide range of relevant methods. Brief introductions to key probabilistic terms are provided at the beginning of the book in order to present the notation used, followed by discussions on multivariate techniques such as: Linear regression models, vector and matrix algebra, and random vectors and matrices Multivariate statistical inference, including inferences about both mean vectors and covariance matrices Principal components analysis Canonical correlation analysis Discrimination and classification analysis for two or more populations and spatial smoothing Cluster analysis, including similarity and dissimilarity measures and hierarchical and nonhierarchical clustering methods Intuitive and geometric understanding of concepts is emphasized, and all examples are relatively simple and include background explanations. Computational results and graphs are presented using the freely available R software, and can be replicated by using a variety of software packages. Throughout the book, problem sets and solutions contain partial numerical results, allowing readers to confirm the accuracy of their approach; and a related website features additional resources including the book's datasets and figures. Statistics for Imaging, Optics, and Photonics is an excellent book for courses on multivariate statistics for imaging science, optics, and photonics at the upper-undergraduate and graduate levels. The book also serves as a valuable reference for professionals working in imaging, optics, and photonics who carry out data analyses in their everyday work.
Multivariate Statistics
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Author : Yasunori Fujikoshi
language : en
Publisher: John Wiley & Sons
Release Date : 2011-08-15
Multivariate Statistics written by Yasunori Fujikoshi and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-15 with Mathematics categories.
A comprehensive examination of high-dimensional analysis of multivariate methods and their real-world applications Multivariate Statistics: High-Dimensional and Large-Sample Approximations is the first book of its kind to explore how classical multivariate methods can be revised and used in place of conventional statistical tools. Written by prominent researchers in the field, the book focuses on high-dimensional and large-scale approximations and details the many basic multivariate methods used to achieve high levels of accuracy. The authors begin with a fundamental presentation of the basic tools and exact distributional results of multivariate statistics, and, in addition, the derivations of most distributional results are provided. Statistical methods for high-dimensional data, such as curve data, spectra, images, and DNA microarrays, are discussed. Bootstrap approximations from a methodological point of view, theoretical accuracies in MANOVA tests, and model selection criteria are also presented. Subsequent chapters feature additional topical coverage including: High-dimensional approximations of various statistics High-dimensional statistical methods Approximations with computable error bound Selection of variables based on model selection approach Statistics with error bounds and their appearance in discriminant analysis, growth curve models, generalized linear models, profile analysis, and multiple comparison Each chapter provides real-world applications and thorough analyses of the real data. In addition, approximation formulas found throughout the book are a useful tool for both practical and theoretical statisticians, and basic results on exact distributions in multivariate analysis are included in a comprehensive, yet accessible, format. Multivariate Statistics is an excellent book for courses on probability theory in statistics at the graduate level. It is also an essential reference for both practical and theoretical statisticians who are interested in multivariate analysis and who would benefit from learning the applications of analytical probabilistic methods in statistics.
Contemporary Bayesian Econometrics And Statistics
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Author : John Geweke
language : en
Publisher: John Wiley & Sons
Release Date : 2005-10-03
Contemporary Bayesian Econometrics And Statistics written by John Geweke and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-03 with Mathematics categories.
Tools to improve decision making in an imperfect world This publication provides readers with a thorough understanding of Bayesian analysis that is grounded in the theory of inference and optimal decision making. Contemporary Bayesian Econometrics and Statistics provides readers with state-of-the-art simulation methods and models that are used to solve complex real-world problems. Armed with a strong foundation in both theory and practical problem-solving tools, readers discover how to optimize decision making when faced with problems that involve limited or imperfect data. The book begins by examining the theoretical and mathematical foundations of Bayesian statistics to help readers understand how and why it is used in problem solving. The author then describes how modern simulation methods make Bayesian approaches practical using widely available mathematical applications software. In addition, the author details how models can be applied to specific problems, including: * Linear models and policy choices * Modeling with latent variables and missing data * Time series models and prediction * Comparison and evaluation of models The publication has been developed and fine- tuned through a decade of classroom experience, and readers will find the author's approach very engaging and accessible. There are nearly 200 examples and exercises to help readers see how effective use of Bayesian statistics enables them to make optimal decisions. MATLAB? and R computer programs are integrated throughout the book. An accompanying Web site provides readers with computer code for many examples and datasets. This publication is tailored for research professionals who use econometrics and similar statistical methods in their work. With its emphasis on practical problem solving and extensive use of examples and exercises, this is also an excellent textbook for graduate-level students in a broad range of fields, including economics, statistics, the social sciences, business, and public policy.