Exposure Response Modeling

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Exposure Response Modeling

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Author : Jixian Wang
language : en
Publisher: CRC Press
Release Date : 2015-07-17

Exposure Response Modeling written by Jixian Wang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-17 with Mathematics categories.

Discover the Latest Statistical Approaches for Modeling Exposure-Response Relationships. Written by an applied statistician with extensive practical experience in drug development, this book explores a wide range of topics in exposure-response modeling, from traditional PKPD modeling to other areas in drug development and beyond. It incorporates numerous examples and software programs for implementing novel methods. The book emphasizes dose adjustment and treatment adaptation based on dynamic exposure-response models, illustrates how to apply causal inference to exposure-response modeling in pharmacometrics and epidemiology, and links exposure-response modeling to clinical decision making through model-based decision analysis.

Assessment Of Exposure Response Functions For Rocket Emission Toxicants

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Author : Subcommittee on Rocket-Emission Toxicants
language : en
Publisher: National Academies Press
Release Date : 1998-08-07

Assessment Of Exposure Response Functions For Rocket Emission Toxicants written by Subcommittee on Rocket-Emission Toxicants and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-07 with Science categories.

The U.S. Air Force is developing a model to assist commanders in determining when it is safe to launch rocket vehicles. The model estimates the possible number and types of adverse health effects for people who might be exposed to the ground cloud created by rocket exhaust during a normal launch or during an aborted launch that results in a rocket being destroyed near the ground. Assessment of Exposure-Response Functions for Rocket-Emmission Toxicants evaluates the model and the data used for three rocket emission toxicants: hydrogen chloride, nitrogen dioxide, and nitric acid.

Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment

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Author : David A. Eckerman
language : en
Publisher: CRC Press
Release Date : 1998-08-25

Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment written by David A. Eckerman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-25 with Medical categories.

and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive and developmental effects, effects on the nervous system and lungs, and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community and others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed and illustrated with published data. This authoritative work indicates that, in the case of certain chemicals and in the context of certain specific toxic effects, we have considerable ability to predictively and quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity and quality of information available on response variability and increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.

Risk Analysis Foundations Models And Methods

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Author : Louis Anthony Cox Jr.
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Risk Analysis Foundations Models And Methods written by Louis Anthony Cox Jr. and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Business & Economics categories.

Risk Analysis: Foundations, Models, and Methods fully addresses the questions of "What is health risk analysis?" and "How can its potentialities be developed to be most valuable to public health decision-makers and other health risk managers?" Risk analysis provides methods and principles for answering these questions. It is divided into methods for assessing, communicating, and managing health risks. Risk assessment quantitatively estimates the health risks to individuals and to groups from hazardous exposures and from the decisions or activities that create them. It applies specialized models and methods to quantify likely exposures and their resulting health risks. Its goal is to produce information to improve decisions. It does this by relating alternative decisions to their probable consequences and by identifying those decisions that make preferred outcomes more likely. Health risk assessment draws on explicit engineering, biomathematical, and statistical consequence models to describe or simulate the causal relations between actions and their probable effects on health. Risk communication characterizes and presents information about health risks and uncertainties to decision-makers and stakeholders. Risk management applies principles for choosing among alternative decision alternatives or actions that affect exposure, health risks, or their consequences.

Current Topics In Occupational Epidemiology

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Author : Katherine Venables
language : en
Publisher: Oxford University Press, USA
Release Date : 2013-07-25

Current Topics In Occupational Epidemiology written by Katherine Venables and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-25 with Medical categories.

Written by international leading experts, Current Topics in Occupational Epidemiology provides an in-depth look at current topics of interest ranging from the ageing workforce to surveillance systems.

Investigating Exposures And Respiratory Health In Coffee Workers

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Author : Mohammed Abbas Virji
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-13

Investigating Exposures And Respiratory Health In Coffee Workers written by Mohammed Abbas Virji and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-13 with Medical categories.

Developments In Statistical Evaluation Of Clinical Trials

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Author : Kees van Montfort
language : en
Publisher: Springer
Release Date : 2014-10-07

Developments In Statistical Evaluation Of Clinical Trials written by Kees van Montfort and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-07 with Mathematics categories.

This book describes various ways of approaching and interpreting the data produced by clinical trial studies, with a special emphasis on the essential role that biostatistics plays in clinical trials. Over the past few decades the role of statistics in the evaluation and interpretation of clinical data has become of paramount importance. As a result the standards of clinical study design, conduct and interpretation have undergone substantial improvement. The book includes 18 carefully reviewed chapters on recent developments in clinical trials and their statistical evaluation, with each chapter providing one or more examples involving typical data sets, enabling readers to apply the proposed procedures. The chapters employ a uniform style to enhance comparability between the approaches.

Quantitative Health Risk Analysis Methods

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Author : Louis Anthony Cox Jr.
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-03-17

Quantitative Health Risk Analysis Methods written by Louis Anthony Cox Jr. and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-17 with Medical categories.

This book grew out of an effort to salvage a potentially useful idea for greatly simplifying traditional quantitative risk assessments of the human health consequences of using antibiotics in food animals. In 2001, the United States FDA’s Center for Veterinary Medicine (CVM) (FDA-CVM, 2001) published a risk assessment model for potential adverse human health consequences of using a certain class of antibiotics, fluoroquinolones, to treat flocks of chickens with fatal respiratory disease caused by infectious bacteria. CVM’s concern was that fluoroquinolones are also used in human medicine, raising the possibility that fluoroquinolone-resistant strains of bacteria selected by use of fluoroquinolones in chickens might infect humans and then prove resistant to treatment with human medicines in the same class of antibiotics, such as ciprofloxacin. As a foundation for its risk assessment model, CVM proposed a dramatically simple approach that skipped many of the steps in traditional risk assessment. The basic idea was to assume that human health risks were directly proportional to some suitably defined exposure metric. In symbols: Risk = K × Exposure, where “Exposure” would be defined in terms of a metric such as total production of chicken contaminated with fluoroquinolone-resistant bacteria that might cause human illnesses, and “Risk” would describe the expected number of cases per year of human illness due to fluoroquinolone-resistant bacterial infections caused by chicken and treated with fluoroquinolones.

Encyclopedia Of Ecology

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Author : Brian D. Fath
language : en
Publisher: Newnes
Release Date : 2014-11-03

Encyclopedia Of Ecology written by Brian D. Fath and has been published by Newnes this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-03 with Science categories.

The groundbreaking Encyclopedia of Ecology provides an authoritative and comprehensive coverage of the complete field of ecology, from general to applied. It includes over 500 detailed entries, structured to provide the user with complete coverage of the core knowledge, accessed as intuitively as possible, and heavily cross-referenced. Written by an international team of leading experts, this revolutionary encyclopedia will serve as a one-stop-shop to concise, stand-alone articles to be used as a point of entry for undergraduate students, or as a tool for active researchers looking for the latest information in the field. Entries cover a range of topics, including: Behavioral Ecology Ecological Processes Ecological Modeling Ecological Engineering Ecological Indicators Ecological Informatics Ecosystems Ecotoxicology Evolutionary Ecology General Ecology Global Ecology Human Ecology System Ecology The first reference work to cover all aspects of ecology, from basic to applied Over 500 concise, stand-alone articles are written by prominent leaders in the field Article text is supported by full-color photos, drawings, tables, and other visual material Fully indexed and cross referenced with detailed references for further study Writing level is suited to both the expert and non-expert Available electronically on ScienceDirect shortly upon publication

Cardiovascular Safety In Drug Development And Therapeutic Use

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Author : J. Rick Turner
language : en
Publisher: Springer
Release Date : 2016-07-28

Cardiovascular Safety In Drug Development And Therapeutic Use written by J. Rick Turner and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-28 with Medical categories.

At a time when the field of cardiac safety is going through important changes, this unique book provides the rationale for, and cutting-edge explanations of, new regulatory landscapes that will likely govern cardiac safety assessments globally for the foreseeable future. Exposure-response modeling is already being accepted by regulatory agencies in lieu of the traditional Thorough QT/QTc Study, and the Comprehensive in vitro Proarrhythmia Assay initiative is well under way. Developments in the field of cardiovascular safety are also described and discussed in the book. These include the search for more efficient ways to exonerate new drugs for type 2 diabetes from an unacceptable cardiovascular liability, how best to address off-target blood pressure increases induced by noncardiovascular drugs, and the continued evolution of the discipline of Cardio-oncology. “a resource that will likely serve as a standard for years to come” - Dr Jonathan Seltzer Therapeutic Innovation & Regulatory Science, 2017;51(2):180 “I have no hesitation in recommending this book as a valuable reference source” - Dr Rashmi Shah Journal for Clinical Studies, 2017;9(1):62-63