Extracellular Matrix In Development And Disease
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Extracellular Matrix In Development And Disease
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Author : Julia Thom Oxford
language : en
Publisher: MDPI
Release Date : 2019-02-21
Extracellular Matrix In Development And Disease written by Julia Thom Oxford and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-21 with categories.
This book is a printed edition of the Special Issue "Extracellular Matrix in Development and Disease" that was published in IJMS
Extracellular Matrix In Development And Disease
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Author : Jeffrey H. Miner
language : en
Publisher: Elsevier
Release Date : 2005-11-18
Extracellular Matrix In Development And Disease written by Jeffrey H. Miner and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-18 with Science categories.
Extracellular matrix proteins are serious, common human diseases that are caused by mutations in genes that encode these proteins. This has spurred a great number of researchers to study the extracellular matrix, sometimes by choice and sometimes by necessity. Much progress has been made in the last decade towards understanding what matrix proteins do and how cells interact with and respond to them. Volume 15 is a compilation of reviews by experts in their respective fields. The chapters in this book address the biology of a broad spectrum of extracellular matrix molecules and their functions in development and disease. This book has been designed to focus on a diverse subset of matrix proteins that have been shown to be important for development, function, and disease. The book therefore both presents a broad view of the field and provides crucial details about some of the best-studied matrix molecules. * Written by leaders in the field * Discusses the potential of matrix components to be used as therapeutic tools for the treatment and prevention of cancer * Offers a section on integrin signaling and the development of the central nervous system, detailing the migration of neurons and the glia * Covers a diverse array of molecules such as laminins, collagens, heparan sulfate proteoglycans, integrins, and more
Extracellular Matrix In Development And Disease
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Author : Julia Oxford
language : en
Publisher:
Release Date : 2019
Extracellular Matrix In Development And Disease written by Julia Oxford and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic books categories.
The extracellular matrix in development and disease deals with the molecular and cellular aspects of development and disease. Cells exist in three-dimensional scaffolding called the extracellular matrix. The matrix holds together the millions of cells that make up our blood vessels, organs, skin, and all tissues of the body. The matrix serves as a reservoir of signaling molecules as well. In bacterial cultures, biofilms form as an extracellular matrix and play essential roles in disease and drug resistance. Topics such as matrix structure and function, cell attachment and cell surface proteins mediating cell-matrix interactions, synthesis, regulation, composition, structure, assembly, remodeling, and function of the matrix are included. A common thread uniting the topics is the essential nature that the matrix plays in normal development and pathophysiology. Providing new knowledge will lead us to improved diagnostics, the preventions of disease progression, and therapeutic strategies for the repair and regeneration of tissues. Topics such as the extracellular matrix in hereditary diseases, reproduction, cancer, muscle, and tissue engineering applications, and diverse roles for integrins, are included in this collection.
Extracellular Matrix In Development
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Author : Douglas W. DeSimone
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-15
Extracellular Matrix In Development written by Douglas W. DeSimone and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-15 with Science categories.
Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.
The Extracellular Matrix An Overview
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Author : Robert Mecham
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-02-16
The Extracellular Matrix An Overview written by Robert Mecham and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-16 with Science categories.
Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
Extracellular Matrix Degradation
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Author : William C. Parks
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-04-07
Extracellular Matrix Degradation written by William C. Parks and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-07 with Science categories.
Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.
Proteoglycans In Stem Cells
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Author : Martin Götte
language : en
Publisher: Springer Nature
Release Date : 2021-06-07
Proteoglycans In Stem Cells written by Martin Götte and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-07 with Science categories.
This book provides a state-of-the-art compendium on the role of proteoglycans and glycosaminoglycans during development and in cancer. It also suggests directions for novel therapeutic and biotechnological applications in stem cell biology. Proteoglycans and glycosaminoglycans, as part of the extracellular matrix, are multifunctional modulators of growth factor, cytokine, integrin and morphogen signaling, which determine both self-renewal, senescence and/or differentiation of stem cells during development. Since proteoglycans modulate cell adhesion and migration they are important organizers of the extracellular matrix within the proper stem cell niche. A malfunctioning of proteoglycans and glycosaminoglycans contributes to the cancer stem cell phenotype, which is linked to therapeutic resistance and recurrence in malignant disease. This book is essential reading for anyone interested in the extracellular matrix and its role in development. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
The Role Of Extracellular Matrix In Development
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Author : Robert L. Trelstad
language : en
Publisher: New York : A.R. Liss
Release Date : 1984
The Role Of Extracellular Matrix In Development written by Robert L. Trelstad and has been published by New York : A.R. Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Science categories.
Extracellular Matrix Biology
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Author : Richard O. Hynes
language : en
Publisher:
Release Date : 2012
Extracellular Matrix Biology written by Richard O. Hynes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Cell interaction categories.
In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in regulating cell function. ECM proteins bind to integrins and other cell surface receptors, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during development, tumorigenesis, and other disease states. The contributors examine the various ECM proteins and proteoglycans, ECM receptors such as integrins, and the signaling pathways that mediate the effects of the ECM on cells. They also describe ECM functions in specific biological contexts, including angiogenesis, hemostasis, and thrombosis. Covering not only the biochemistry and cell biology of the ECM but also its roles in development, physiology, and pathology, this volume is an indispensable reference for cell biologists and all those interested in exploring the myriad functions of the ECM.
The Role Of Extracellular Matrix In Development
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Author : Robert L. Trelstad
language : en
Publisher: Wiley-Liss
Release Date : 1984-07-12
The Role Of Extracellular Matrix In Development written by Robert L. Trelstad and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984-07-12 with Science categories.