Fast Facts Egfr Exon 20 Insertion Mutations In Nsclc
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Fast Facts Egfr Exon 20 Insertion Mutations In Nsclc
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Author : Julia Rotow
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2022-06-30
Fast Facts Egfr Exon 20 Insertion Mutations In Nsclc written by Julia Rotow and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-30 with Medical categories.
Lung cancer is still a major cause of death globally, but the development of personalized, precision medicine has had a marked effect on treatment management and improved clinical outcomes, particularly for those with advanced stage non-small-cell lung cancer (NSCLC). EGFR mutations are the third most common mutation found in patients with advanced stage NSCLC. First-line treatment with a traditional epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) is indicated for most patients, but not for patients with EGFR exon 20 insertion mutations (ex20ins). Instead, recent approvals of an EGFR ex20ins-specific TKI (mobocertinib) and a bispecific antibody (amivantamab) targeting both EGFR and mesenchymalepithelial transition factor (MET) offer the potential for improved outcomes in this patient population. Furthermore, new approaches to treatment continue to be developed and trials for new agents with greater activity against ex20ins mutations are ongoing. Table of Contents: • EGFR and mutations • EGFR mutation testing • Treatment decisions • Therapies in development
Fast Facts Egfr Exon 20 Insertion Mutations In Nsclc
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Author : J. Rotow
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2022-06-13
Fast Facts Egfr Exon 20 Insertion Mutations In Nsclc written by J. Rotow and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-13 with Medical categories.
Lung cancer is still a major cause of death globally, but the development of personalized, precision medicine has had a marked effect on treatment management and improved clinical outcomes, particularly for those with advanced stage non-small-cell lung cancer (NSCLC). EGFR mutations are the third most common mutation found in patients with advanced stage NSCLC. First-line treatment with a traditional epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) is indicated for most patients, but not for patients with EGFR exon 20 insertion mutations (ex20ins). Instead, recent approvals of an EGFR ex20ins-specific TKI (mobocertinib) and a bispecific antibody (amivantamab) targeting both EGFR and mesenchymalepithelial transition factor (MET) offer the potential for improved outcomes in this patient population. Furthermore, new approaches to treatment continue to be developed and trials for new agents with greater activity against ex20ins mutations are ongoing.
Fast Facts Non Small Cell Lung Cancer
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Author : Mary O'Brien
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2022-02-28
Fast Facts Non Small Cell Lung Cancer written by Mary O'Brien and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-28 with Medical categories.
Despite an overall decrease in tobacco use, lung cancer (80–85% of which is non-small-cell lung cancer [NSCLC]) is still the leading cause of cancer death in both men and women worldwide. Annual low-dose CT screening of high-risk individuals has the potential to detect early-stage tumors, which can usually be successfully treated with a combination of surgery, radiotherapy and chemotherapy and, in some cases, targeted therapy. However, most patients with NSCLC still present with advanced or metastatic disease. For these patients, initial therapy is guided by the tumor’s molecular characteristics and patient’s performance status. Targeted therapies have significantly improved clinical outcomes and, for some patients with no targetable genetic alterations, immunotherapy has demonstrated significant overall survival benefit. This insightful guide is designed to bring you up to speed with the latest developments and is important reading for all health professionals and medical trainees working in this fast-moving field. Table of Contents: • Prevention and screening • Diagnosis and staging • Surgery • Radiotherapy • Systemic therapy in non-metastatic NSCLC • Systemic therapy in advanced-stage/metastatic disease without a molecular driver • Personalized treatment in advanced NSCLC • Oligometastatic disease and brain metastases
Molecular Pathology Of Lung Cancer
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Author : Philip T. Cagle
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-14
Molecular Pathology Of Lung Cancer written by Philip T. Cagle and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-14 with Medical categories.
As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.
Pathology Of Sinonasal Tumors And Tumor Like Lesions
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Author : Alessandro Franchi
language : en
Publisher: Springer Nature
Release Date : 2019-11-11
Pathology Of Sinonasal Tumors And Tumor Like Lesions written by Alessandro Franchi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-11 with Medical categories.
This book provides a comprehensive, up-to-date review of the field of diagnostic histopathology of sinonasal tumors and tumor-like lesions. It includes well-known and recently described structures, focusing on their epidemiological, clinical, radiological, and molecular features. It also discusses the latest surgical and medical treatment of these tumors. Primarily written for pathologists and pathology residents, the topics discussed make it a valuable resource for head and neck surgeons, radiologists, oncologists, and other clinical physicians. Written by experts in the field, this book further our understanding of the pathology of sinonasal tumors.
Targeted Therapies For Lung Cancer
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Author : Ravi Salgia
language : en
Publisher: Springer
Release Date : 2019-06-26
Targeted Therapies For Lung Cancer written by Ravi Salgia and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-26 with Medical categories.
This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.
Fast Facts Comprehensive Genomic Profiling
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Author : Bernardo L. Rapoport
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2020-10-20
Fast Facts Comprehensive Genomic Profiling written by Bernardo L. Rapoport and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-20 with Medical categories.
Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject. Contents: • Genetic mutations and biomarkers • Understanding next-generation sequencing • Elements of comprehensive genomic profiles • Role in precision oncology • Predictive and prognostic biomarkers • Overcoming barriers to genotype-directed therapy
Therapeutic Strategies In Egfr Mutant Lung Cancer
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Author : Yaxiong Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-03
Therapeutic Strategies In Egfr Mutant Lung Cancer written by Yaxiong Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-03 with Medical categories.
Small Molecules In Oncology
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Author : Uwe M. Martens
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-01-14
Small Molecules In Oncology written by Uwe M. Martens and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-14 with Medical categories.
Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.
Mosby S Oncology Nursing Advisor E Book
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Author : Susan Maloney-Newton
language : en
Publisher: Elsevier Health Sciences
Release Date : 2023-09-05
Mosby S Oncology Nursing Advisor E Book written by Susan Maloney-Newton and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-05 with Medical categories.
NEW! Updated content reflects the latest evidence-based information, including cancer biology, cancer treatment modalities, the latest chemotherapy guidelines, and a stronger emphasis on oral agents. NEW! New content addresses the concept of "previvorship," the concept of coping with a documented genetically linked high cancer risk. NEW! Enhanced content on health disparities, diversity and inclusion, and transgender considerations equips oncology nurses with essential information to promote health equity. NEW! Key recommendations of the 2020-2030 Future of Nursing Report are integrated into the Nursing Practice Considerations section. NEW! Content on the impact of the COVID pandemic includes delayed diagnosis and treatment and the impact of COVID sequelae on the health of patients with cancer. NEW! Added content on palliative care is included in an expanded Pain chapter. NEW! Full-color design and additional illustrations make it easier to use the book and to understand concepts. NEW! Pulmonary Symptoms chapter now includes cough, dyspnea, and pleural effusion content.