Feola S Cross
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Feola S Cross
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Author : Colleen Forte
language : en
Publisher: Xlibris Corporation
Release Date : 2001-07
Feola S Cross written by Colleen Forte and has been published by Xlibris Corporation this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07 with Fiction categories.
FEOLA'S CROSS sways with the pendulum of the public's interest from escapism to the fascination of life's cold realities. This family's story screams realism. Joey Feola has only horror from perverse personal violation after his commitment to Woodhaven Asylum. He has no inkling that he will be murdered by a sadistic orderly, Willard Earle, for a carton of cigarettes. But the carton of cigarettes will not be the only thing stolen the orderly accidently discovers a solid gold cross, inset with a precious ruby. It is the Feola cross, bequeathed to Joey's grandmother, Josephine, before her prearranged marriage in America. Ten years earlier, in his grandmother's darkened kitchen, eleven-year-old Nick Feola witnessed the passing of the cross to his older brother, Joey, and the passing of something darker; the family gene for schizophrenia. At twenty-one, Nicky is drafted. He survives boot camp, only to be sent to the gruesome bush of Vietnam. It is in this dark arena vengeance rears its diabolical head beckoning Nick's decision of retribution for his brother's murder.
Feola S Cross
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Author : Colleen Forte
language : en
Publisher: Xlibris Corporation
Release Date : 2001-07-19
Feola S Cross written by Colleen Forte and has been published by Xlibris Corporation this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-19 with Fiction categories.
FEOLA’S CROSS sways with the pendulum of the public’s interest from escapism to the fascination of life’s cold realities. This family’s story screams realism. Joey Feola has only horror from perverse personal violation after his commitment to Woodhaven Asylum. He has no inkling that he will be murdered by a sadistic orderly, Willard Earle, for a carton of cigarettes. But the carton of cigarettes will not be the only thing stolen – the orderly accidently discovers a solid gold cross, inset with a precious ruby. It is the Feola cross, bequeathed to Joey’s grandmother, Josephine, before her prearranged marriage in America. Ten years earlier, in his grandmother’s darkened kitchen, eleven-year-old Nick Feola witnessed the passing of the cross to his older brother, Joey, and the passing of something darker; the family gene for schizophrenia. At twenty-one, Nicky is drafted. He survives boot camp, only to be sent to the gruesome bush of Vietnam. It is in this dark arena vengeance rears its diabolical head beckoning Nick’s decision of retribution for his brother’s murder.
Walters Karram Urogynecology And Reconstructive Pelvic Surgery
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Author : Matthew D. Barber
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-10-22
Walters Karram Urogynecology And Reconstructive Pelvic Surgery written by Matthew D. Barber and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-22 with Medical categories.
Uniquely designed to reflect the physician’s decision-making process, Walters & Karram Urogynecology and Reconstructive Pelvic Surgery presents definitive, state-of-the-art guidance on every aspect of female pelvic medicine and reconstructive surgery. This practical, atlas-style resource covers everything from basic concepts through to clinical and urodynamic evaluation, management, and treatment, equipping you to make the best clinical decisions and optimize outcomes. Edited and authored by renowned experts in the field, this updated 5th Edition is an ideal resource for urogynecology fellows and practitioners, urologists, and OB/GYNs who need a step-by-step, comprehensive reference on the latest procedures and research to evaluate and treat female pelvic floor disorders. Offers a comprehensive approach to all urogynecologic disorders, including genuine stress incontinence, pelvic organ prolapse, defecation disorders, painful and irritative voiding disorders, and specific conditions such as urinary tract infection. Provides algorithmic approaches to common complaints, evidence-based assessments of appropriate therapies, and hundreds of clear surgical illustrations, photographs, and radiographs. Features an all-new video collection to clearly demonstrate key procedures. Contains new chapters on Urology for the Urogynecologist and Interstitial Cystitis/Bladder Pain Syndrome. Contains timely discussions of surgical complications, the psychosocial issues associated with treating patients with female pelvic floor disorders, and female sexual function and dysfunction. Includes case presentations from leading experts in urogynecology and urology that allow you to apply the information presented to everyday clinical situations.
T Cell Specificity And Cross Reactivity Implications In Physiology And Pathology
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Author : Samuele Notarbartolo
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-07
T Cell Specificity And Cross Reactivity Implications In Physiology And Pathology written by Samuele Notarbartolo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-07 with Medical categories.
Conventional CD8+ and CD4+ T cells recognize antigens, presented by antigen-presenting cells in the form of short peptides loaded onto major histocompatibility complex (MHC) class I and class II molecules, through their T cell receptor (TCR). Somatic gene rearrangement of the TCR locus and randomization of TCR hyper-variable regions generate the marked diversity of TCRs. Once assembled, the heterodimeric TCR confers specificity to naïve T cells. The naïve T cell repertoire of an individual is established by selection processes in the thymus and cannot be broadened upon antigen recognition by additional somatic mutations. In humans, the estimated number of distinct TCRs in the naïve T cell pool is several orders of magnitude lower than the possible array of peptides that can be generated and accommodated into an MHC molecule. This challenge can be overcome by T cell cross-reactivity, that is the ability of a single TCR to bind multiple peptide-MHC complexes. T-cell cross-reactivity can have both positive and negative consequences. First, it allows for covering a wide range of foreign peptides with a limited repertoire of T cells. Second, it facilitates polyclonal immune responses to a single peptide and increases resistance to escape mutations. Third, it can induce heterologous immunity, that is the generation of memory to a pathogen different from the one against which the immune response has been originally raised. On the contrary, a negative consequence of T-cell cross-reactivity is the possibility of self-antigen recognition, potentially causing autoimmunity. The lower activation threshold of memory T-cells compared to naïve T-cells increases this risk, partially eluding the thymic negative selection checkpoint. Moreover, heterologous immunity can be detrimental when the type of memory T-cell polarization induced by the first pathogen is inappropriate to control the second pathogen.
Nanoparticle Mediated Immunotherapy
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Author : Tuan Vo-Dinh
language : en
Publisher: Springer Nature
Release Date : 2021-10-12
Nanoparticle Mediated Immunotherapy written by Tuan Vo-Dinh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-12 with Science categories.
This book is intended to serve as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of nanotechnology in immunotherapy. The combination of nanotechnology and immunotherapy is recognized as a promising treatment modality. In particular, the use of nanoparticles in immunotherapy has attracted increased attention for their unique efficacy and specificity in cancer treatment. A wide variety of nanoparticles, such as polymeric and liposomal nanosystems, carbon nanotubes, and gold nanoparticles have provided important nanoplatforms for immunotherapeutic approaches. They have been shown to improve delivery and efficacy of immunotherapeutic agents such as vaccines or adjuvants. Nanoparticle-mediated thermal therapy has demonstrated the effectiveness for precise tumor cell ablation, radio-sensitization of hypoxic regions, enhancement of drug delivery, activation of thermosensitive agents, and enhancement of the immune system. Plasmonic nanoparticles are a special type of metallic nanoparticles that has received great interest due to their enhanced optical and electromagnetic properties and their superior capacity to convert photon energy into heat for selective photothermal therapy at the nanoscale level. Nanoparticle sizes can also be controlled such that they accumulate preferentially in tumors due to the enhanced permeability and retention effect of tumor vasculature. Various nanosystems such as gold nanoparticles have also been shown to stimulate the immune system. Immunotherapies could thus synergistically benefit from the combination with targeted nanoparticle-mediated photothermal therapies, especially when hyperthermia around immune-checkpoint inhibitors in the tumor bed is combined with precise thermal ablation of cancer cells. Of great importance is the possibility that such an approach can induce long-term immunological memory that can provide protection against tumor recurrence long after treatment of the initial tumors, like an ‘anticancer vaccine’. Nanoparticle-mediated immunotherapy could lead to an entirely new treatment paradigm that challenges traditional surgical resection approaches for many cancers and metastases.
Handbook Of Stem Faculty Development
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Author : Sandra M. Linder
language : en
Publisher: IAP
Release Date : 2022-12-01
Handbook Of Stem Faculty Development written by Sandra M. Linder and has been published by IAP this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-01 with Education categories.
Faculty in the science, technology, engineering, and mathematics (STEM) disciplines face intensifying pressures in the 21st century, including multiple roles as educator, researcher, and entrepreneur. In addition to continuously increasing teaching and service expectations, faculty are engaged in substantive research that requires securing external funding, mentoring other faculty and graduate students, and disseminating this work in a broad range of scholarly outlets. Societal needs of their expertise include discovery, innovation, and workforce development. It is critical to provide STEM faculty with the professional development to support their complex roles and to base this development on evidence derived from research. This edited handbook provides STEM stakeholders with an opportunity to share studies and/or experiences that explore STEM faculty development (FD) in higher education settings. More specifically, we include work that examines faculty development planning, techniques/models, experiences, and outcomes focused on supporting the teaching, research, service, and leadership responsibilities of STEM faculty. The Handbook is suited for researchers and practitioners in STEM, STEM Education, Mathematics, Science, Technology, and Engineering disciplines. It is also suited towards faculty developers, higher education administrators, funding agencies, industry leaders, and the STEM community at large. This handbook is organized around three constructs (INPUTS, MECHANISMS, and OUTPUTS). The STEM faculty development inputs construct focuses on topics related to the characteristics of faculty members and institutions that serve as barriers or supports to the adoption and implementation of holistic STEM faculty development programs. Questions addressed in the handbook around this topic include: What barriers/supports exist for STEM faculty? How are these barriers/supports being addressed through STEM FD? How do contexts (e.g., economic, political, historical) influence faculty/administrative needs related to STEM FD? How do demographics (e.g., gender, ethnicity, age, family background) influence faculty/administrative needs related to STEM FD? The STEM faculty development mechanisms construct focuses on topics related to the actual implementation of STEM faculty development and we consider the potential models or structures of STEM faculty development that are currently in place or conceptualized in theory. Questions addressed in the handbook around this topic include: What are the processes for developing models of STEM FD? What are effective models of STEM FD? How is effectiveness determined? What roles do stakeholders (e.g., faculty, administration, consultants) play within STEM FD mechanisms? The STEM faculty development outputs construct focuses on how to best understand the influence of STEM faculty development on outcomes such as productivity, teacher quality, and identity in relation to faculty development. Questions addressed in the handbook around this topic include: How has STEM FD influenced higher education practices and settings? What are appropriate output measures and how are they used in practice? What collaborations emerge from STEM FD? How does STEM FD affect other STEM stakeholders (e.g. students, administration, business, community)? The aim for this handbook was to examine the multifaceted demands of faculty roles, and together with members of the STEM education community, envision pathways through which universities and individuals may support STEM colleagues, regardless of their experience or rank, to enjoy long and satisfying careers. Our hope is for these chapters to aid readers in deep reflection on challenges faculty face, to contemplate adaptations of models presented, and to draw inspiration for creating or engaging in new professional development programs. Chapters across this handbook highlight a variety of institutional contexts from 2-year technical colleges, to teaching-focused institutions, in addition to research-centric settings. Some chapters focus primarily on teaching and learning practices and offer models for improving STEM instruction. Others focus on barriers that emerge for STEM faculty when trying to engage in development experiences. There are chapters that examine tenure structures in relation to faculty development and how STEM FD efforts could support research endeavors. Mentorship and leadership models are also addressed along with a focus on equity issues that permeate higher education and impact STEM FD. It is our sincere hope that this Handbook sparks increased discourse and continued explorations related to STEM FD, and in particular, the intentional focus of faculty development initiatives to extend to the many facets of academic life.
Host Response To Biomaterials
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Author : Stephen F. Badylak
language : en
Publisher: Academic Press
Release Date : 2015-05-08
Host Response To Biomaterials written by Stephen F. Badylak and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-08 with Medical categories.
Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine. Explains the various categories of biomaterials and their significance for clinical applications Contains a range of extensive coverage, including, but not limited to, orthopedic, surgery, dental, general surgery, neurosurgery, lower urinary tract, and regenerative medicine Includes regulations regarding combination devices
Blood Substitutes And Oxygen Biotherapeutics
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Author : Henry Liu
language : en
Publisher: Springer Nature
Release Date : 2022-08-08
Blood Substitutes And Oxygen Biotherapeutics written by Henry Liu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-08 with Medical categories.
This book functions as a comprehensive and authoritative reference book in blood transfusion and blood substitutes. It is a collection of the latest developments and the newest investigations, and individual chapters are written by world experts in the arena. The book begins with a historical review on the practice of transfusions as well as the components and physiology of blood. The following chapters cover various topics, including platelet substitutes, hemoglobin-based oxygen carriers, perfluorocarbon based oxygen carriers, and safety issues related to artificial hemoglobin. All chapters provide a bulleted highlights list to facilitate readers in mastering the main points of each individual chapter. Blood Substitutes and Oxygen Biotherapeutics is an invaluable reference book for perioperative care providers, hematologists, anesthesiologists, surgeons, obstetricians and gynecologists.
West S Federal Practice Digest 2d
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Author :
language : en
Publisher:
Release Date : 1976
West S Federal Practice Digest 2d written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Law reports, digests, etc categories.
Scotland S Mountain Ridges
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Author : Dan Bailey
language : en
Publisher: Cicerone Press Limited
Release Date : 2011-07-21
Scotland S Mountain Ridges written by Dan Bailey and has been published by Cicerone Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-21 with Sports & Recreation categories.
A guidebook to the rich mix of summer scrambling, rock climbing and winter mountaineering on Scotland's ridges, from the remote Cairngorms to the splendour of the Cuillin. Graceful carved walkways slung between summits, twisted spines of stone - ridges can be the most beautiful of mountain landforms. With elegant lines and giddy exposure, ridge climbs emit a powerful siren call, drawing us out onto the rocks. Life on the edge has a special quality, born of the contrast of empty space all around, and intricate detail in close-up. The crests are strangely irresistible. Scotland's ridges are among the finest mountaineering lines in the country, every one a unique adventure. The variety of these routes reflects the breadth of the mountain experience: a rich mix of summer scrambles, technical rock and challenging winter climbs. This book covers both the popular classics and some obscure gems, aiming to celebrate these thrilling climbs as much as to document them. Along the way it explores landscapes of magnificent diversity, ranging from the remote desolation of the Cairngorms to the seaside splendour of the Cuillin, the great trench of Glencoe to the surreal exhibitionism of the far north. The chosen selection spans the grade range, with routes to suit all levels of ability. Whether an earthbound hillwalker or an accomplished climber, Scotland's ridges cannot fail to stir your imagination.
