Fgf Signalling In Vertebrate Development
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Fgf Signalling In Vertebrate Development
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Author : Mary Elizabeth Pownall
language : en
Publisher: Biota Publishing
Release Date : 2010-05-01
Fgf Signalling In Vertebrate Development written by Mary Elizabeth Pownall and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-01 with Science categories.
The fibroblast growth factors (FGFs) represent one of the relatively few families of extracellular signalling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple processes in both protostome and deuterostome groups. Given the wide range of regulatory roles attributed to the FGFs, it is perhaps not surprising that misregulation of this signalling pathway has been implicated in a number of human disease conditions. The focus of the present review is to look at the fundamental components of the FGF pathway and illustrate how this highly conserved regulatory cassette has been deployed to regulate multiple, diverse processes during vertebrate development. This review will explore examples from several vertebrate model organisms and include discussions of the role of FGF signalling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development, and the establishment of right–left asymmetry.
Defining The Role Of Fibroblast Growth Factor Signaling In Vertebrate Limb Development
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Author : Jamie M. Verheyden
language : en
Publisher:
Release Date : 2008
Defining The Role Of Fibroblast Growth Factor Signaling In Vertebrate Limb Development written by Jamie M. Verheyden and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Signalling Pathways In Embryonic Development
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Author : Juan J. Sanz-Ezquerro
language : en
Publisher: Frontiers Media SA
Release Date : 2017-11-30
Signalling Pathways In Embryonic Development written by Juan J. Sanz-Ezquerro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-30 with Electronic book categories.
The formation of a complex multicellular organism from a single cell is one of the most amazing processes of biology. Embryonic development is characterised by the careful regulation of cellular behaviours such that cells proliferate, migrate, differentiate and form tissues at the correct place and time. These processes are genetically controlled and depend both on the history of cells, their lineage, and on the activities of signalling pathways, which coordinate the cell interactions leading to organogenesis. The aim of the Frontiers research topic “Signalling pathways in embryonic development” has been to provide a forum for experts in cell and developmental biology to share recent advances in the field of signalling during embryonic development. Sixteen articles in a variety of formats are united in this Topic, offering a valuable collection for researchers looking for an update in the knowledge of signalling pathways operating during embryogenesis. The works, focused mainly on vertebrates, explore different aspects of this theme from cell communication to organ formation and have implications for areas as distant as evolution or pathology. Understanding developmental signalling pathways is important for several reasons. It gives us information about basic mechanisms of cell function and interactions needed for morphogenesis and organogenesis. It uncovers the basis of congenital malformations, since errors at any step of cell signalling during development are a major cause of defects. This fundamental insight gives us clues to understand the mechanisms operating in evolution that explain diversity in form and function. And finally, it allows the identification of possible causes of disease in the adult organism (such as cancer or degenerative diseases) pinpointing possible targets for therapeutic approaches.
The Fibroblast Growth Factor Family
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Author : Andrew Baird
language : en
Publisher:
Release Date : 1991
The Fibroblast Growth Factor Family written by Andrew Baird and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
Cell Signaling Pathways In Development
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Author :
language : en
Publisher: Academic Press
Release Date : 2022-05-20
Cell Signaling Pathways In Development written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-20 with Science categories.
Cell Signaling Pathways in Development, Volume 149 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Ephrin signaling, Cell signaling to the extracellular matrix, Signaling by TGF-b superfamily members, Hedgehog signaling, Parallels in signaling during development and regeneration, Hippo signaling, Wnt/PCP signaling, Signaling oscillations in presomitic mesoderm, FGFs/RTKs subcellular signaling compartments, and Signaling dynamics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Includes the latest information on Cell Signaling Pathways in Development
Wnt Beta Catenin Signaling In Vertebrate Posterior Neural Development
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Author : Yaniv Elkouby
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2010
Wnt Beta Catenin Signaling In Vertebrate Posterior Neural Development written by Yaniv Elkouby and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
The Wnt/β-catenin signaling pathway is a key regulator of cell fate specification, differentiation, and growth in multiple systems throughout the animal kingdom. In vertebrate posterior neural development, Wnt/β-catenin signaling controls this complex multistep process. It initially induces the posterior regions of the nervous system, including the mid-hindbrain border, hindbrain, spinal cord and neural crest, and then subsequently fine-tunes the pattern of each region and determines the different cell fates within them. In this review, we explore the function of the Wnt/β-catenin pathway during the formation of these specific posterior neural regions. We have examined the important transcriptional targets of the Wnt/β-catenin pathway acting downstream to mediate its morphogenetic activity. Different regulatory networks are activated in different posterior neural regions, and these networks induce specific neural cell types in each region. Eludidating how each of these networks specify different cell fates is crucial for understanding the basic tenets of how Wnt morphogenetic activity induces the posterior nervous system during the earliest stages of vertebrate development. Table of Contents: Introduction / Making the Neural Rear / Wnt Morphogenetic Activity in Neural Posterior Induction / Induction of the Midbrain-Hindbrain Border / Induction of the Hindbrain / Induction of the Spinal Cord / Downstream of Wnt: Hindbrain or Spinal Cord? / Neural Crest Induction / Anti-Wnt Anterior Determinants / The Role of Mesoderm and Specific Wnt Ligands in Neural Patterning / Concluding Remarks / References
The Vertebrate Organizer
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Author : Horst Grunz
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-02-20
The Vertebrate Organizer written by Horst Grunz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-02-20 with Medical categories.
The organizer area plays a central role in the formation of the embryonic axis and the central nervous system of all vertebrates including the human fetus. In The Vertebrate Organizer outstanding molecular development biologists and embryologists report their latest approaches in this fascinating research area using different vertebrate model organisms. The presented data are of central importance for the understanding of early human embryogenesis.
Vertebrate Skeletal Development
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-03-20
Vertebrate Skeletal Development written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-20 with Science categories.
Vertebrate Skeletal Development, Volume 133, the latest release in the Current Topics in Developmental Biology series, presents interesting chapters on a variety of topics, with this edition focusing on Craniofacial skeletal development, Regulatory mechanism of jawbone and tooth development, Development of the axial skeleton and intervertebral discs, Stem and progenitor cells in skeletal development, Origin, functioning and morphogenetic activity of limb synovial joint, ECM signaling in cartilage development and endochondral ossification, Sox genes in skeletal development, Wnt-Signaling in Skeletal Development, Gαs signaling in skeletal development and diseases, FGF signaling in skeletal development, Bone morphogenetic growth factors in bone development, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Includes the latest information on Vertebrate Skeletal Development
Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics
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Author : Simons Michael
language : en
Publisher: World Scientific
Release Date : 2016-12-27
Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics written by Simons Michael and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-27 with Medical categories.
The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states. Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches. With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments — endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer. It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.
Cell Cell Signaling In Vertebrate Development
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Author : E.J. Robertson
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Cell Cell Signaling In Vertebrate Development written by E.J. Robertson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Cell-Cell Signaling in Vertebrate Development provides a comprehensive discussion of cell-cell interactions in vertebrate development and the molecular signals that mediate them. The book is divided into six parts, arranged according to major developmental phenomena demonstrated in illustrative systems derived from amphibian, avian, mammalian, and piscine sources. Part I introduces the mechanisms of gene activation in the context of early vertebrate development. Part II is concerned with cellular contacts and the induction process. Cell-cell interactions are illustrated through analyses of neurogenesis in the mouse; embryonic induction is considered in the frog and in the chick. Part III deals with cell migration and differentiation. It examines cell lineages in the frog eyebud; migration phenomena in connection with axon guidance in the embryonic rat spinal cord and mouse visual system; pathfinding by primary motoneurons; and the formation of terminal arbors in zebrafish embryos. Part IV discusses developmental processes that depend on diffusible signals and signal gradients. Part V illustrates pattern formation as exemplified in the developing chick hindbrain and in urodele limb regeneration. Part VI highlights gene expression and its regulation by transcription factors or growth factors in rodent development.