Flavonoids In Cell Function
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Flavonoids In Cell Function
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Author : Béla Buslig
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Flavonoids In Cell Function written by Béla Buslig and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.
The discovery of biological activity associated with flavonoid contaminants in vitamin C preparations from bell peppers and lemons by Szent-Gyorgyi and his associates opened a floodgate of research into the biological functions of this ubiquitous and diverse group of compounds. Since then, a broad range of physiological and biochemical activities were discovered in living systems including most plants and animals. With the continued discovery, isolation and identification of new natural and synthetic compounds exhibiting biological activities, entire research programs are devoted to wide ranging investigations to nearly every conceivable area, from microbial and plant interaction, growth regulation and development to physiological, genetical, medicinal actions and uses in animals. This volume is based on presentations made at a Symposium, titled Flavonoids in Cell Function, held during the 219'h National Meeting of the American Chemical Society held in San Francisco, California on March 29-30, 2000. The book is not intended to be a comprehensive treatise on flavonoid research, only a sampling of recent results. The papers cover a range of topics discussing various approaches to flavonoid study, starting at plant microbe communication through analytical methods to medicinal and systemic implications of these compounds in animal cells and systems. The organizers would like to express their thanks to Cargill Foods, Inc., Minneapolis, Minnesota and the Division of Agricultural and Food Chemistry of the American Chemical Society for financial support. A great deal of thanks is also due to the authors without whose cooperation and patience this volume would not be realized.
Investigation Of The Role Of Dietary Flavonoids On Cell Death
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Author : Tetiana Lialiutska
language : en
Publisher:
Release Date : 2012
Investigation Of The Role Of Dietary Flavonoids On Cell Death written by Tetiana Lialiutska and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Apoptosis categories.
Flavonoids are polyphenolic compounds widely distributed in plants and have been shown to be cytotoxic to cancer cells. Our lab has previously shown that some flavonoids are able to induce cytotoxicity and inhibit caspase activity in human breast cancer cell lines. The goal of our study was to identify the specific molecular pathways required for flavonoid-induced cytotoxicity. MDA-MB-231 cells, mouse embryonic fibroblasts (MEFs) lacking caspase 3 and 7, and primary baby mouse kidney epithelial cells lacking Bax and Bak were cultured. Flavonoid-treated MDA-MB-231 cells showed cytochrome c release. We detected caspase 3 activation and PARP cleavage in MDA-MB-231 cells after treatment with some flavonoids. Quercetin did not activate caspase 3 but induced PARP cleavage at early time points. These results suggested that cytotoxicity in breast cancer cells involved caspase-independent mechanisms. To further test this, we treated wild-type and caspase-deficient MEFs with various flavonoids and performed cell death assays. Flavonoid-induced cell death in caspase-deficient MEFs and Bax/Bak deficient cell lines was similar to wild-type cells. Taken together, our results suggested that flavonoids induce cell death through caspase-independent mechanisms.
Flavonoids And Related Compounds
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Author : Jeremy P. E. Spencer
language : en
Publisher: CRC Press
Release Date : 2012-04-24
Flavonoids And Related Compounds written by Jeremy P. E. Spencer and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-24 with Medical categories.
Flavonoids exert a multiplicity of biological effects on humans and can have beneficial implications for numerous disease states. Flavonoids and Related Compounds: Bioavailability and Function examines current knowledge regarding the absorption, metabolism, and bioavailability of individual flavonoids and related phenolic compounds. Profiling
Flavonoids In Health And Disease Second Edition
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Author : Catherine A. Rice-Evans
language : en
Publisher: CRC Press
Release Date : 2003-05-20
Flavonoids In Health And Disease Second Edition written by Catherine A. Rice-Evans and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-05-20 with Medical categories.
Revised and expanded throughout, this blue-ribbon reference emphasizes the latest developments in the identification, utilization, and analysis of flavonoids for the prevention of disease and maintenance of good health-examining the processes involved in the absorption, metabolism, distribution, and excretion of these compounds and the impact of biotransformation on flavonoid function.
Flavonoids
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Author : José Justino
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-08-23
Flavonoids written by José Justino and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-23 with Science categories.
Flavonoids are abundant secondary metabolites found in plants and fungi that have various roles in these organisms, including pigmentation, cell signalling, plant defence and inter-organism communication. Due to their abundance in nature, flavonoids are also important components of the human diet, and the last four decades have seen an intense study focused on the structure characterization of flavonoids and on their roles in mammal metabolism. This book reviews most of the well-established activities of flavonoids, and we also present more recent research studies on the area of flavonoids, including the chemical aspects of structure characterization of flavonoids, the biosynthesis of flavonoids in model plants as well as their role in abiotic stress situations and in agriculture, the role of flavonoids in metabolism and health and their importance in foods, from consumption to their use as bioactive components.
Flavonoids In The Living System
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Author : John Manthey
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Flavonoids In The Living System written by John Manthey and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The presence of contaminant flavonoids in vitamin C preparations from citrus fruits initially led Szent-Gyorgyi and his collaborators to suggest that a flavonoid compound, with biological activity for the prevention of capillary fragility, was vitamin P. Later re search, although not disproving biological activity, discontinued the use of the vitamin classification for these compounds. However, the ubiquitous distribution of flavonoids in living organisms, and the continued discovery of various activity in biological systems makes these compounds targets of wide ranging investigation. This volume is primarily based on a Symposium on Flavonoids and related com pounds held during the 212th National Meeting of the American Chemical Society held in Orlando, Florida on August 28-29, 1996 under the sponsorship of the Division of Agricul tural and Food Chemistry. While the book is not intended to be a comprehensive volume on flavonoid research, the papers provide various approaches to exploring the biological functions of flavonoids in plants and animals, their chemical modifications for enhanced activity, some analytical techniques, as well as their use in food classification. A signifi cant portion is devoted to medicinal implications of these compounds. The organizers would like to express their appreciation to Tropicana Products, Inc., Bradenton, Florida, Coca-Cola Foods Division, Plymouth, Florida and the American Chemical Society's Division of Agricultural and Food Chemistry for financial support. Of course, the book could not be produced without the authors, whose cooperation and pa tience is greatly appreciated.
Flavonoids And Anti Aging
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Author : Karam F.A. Soliman
language : en
Publisher: CRC Press
Release Date : 2023-05-03
Flavonoids And Anti Aging written by Karam F.A. Soliman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-03 with Medical categories.
The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover, many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases. Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2, can have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Flavonoids are an essential ingredient in nutraceuticals, functional foods, and pharmaceuticals. The present book Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2 focuses on the interaction between Nrf2 and flavonoids and their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative disease and many other areas. Key Features: Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and "WELLNESS" molecule Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals Presents flavonoid-based functional foods Discusses the flavonoid nutraceuticals market and future trends Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.
Flavonoids And Their Disease Prevention And Treatment Potential
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Author : H.P. Vasantha Rupasinghe
language : en
Publisher: MDPI
Release Date : 2021-03-29
Flavonoids And Their Disease Prevention And Treatment Potential written by H.P. Vasantha Rupasinghe and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-29 with Science categories.
Flavonoids are ubiquitously present in plant-based foods and natural health products. The molecule of flavonoids is characterized by a 15-carbon skeleton of C6–C3–C6, with the different structural configuration of subclasses. The major subclasses of flavonoids with health-promotional properties are the flavanols or catechins (e.g., epigallocatechin 3-gallate from green tea), the flavones (e.g., apigenin from celery), the flavonols (e.g., quercetin glycosides from apples, berries, and onion), the flavanones (e.g., naringenin from citrus), the anthocyanins (e.g., cyanidin-3-O-glucoside from berries), and the isoflavones (e.g., genistein from soya beans). Scientific evidence has strongly shown that regular intake of dietary flavonoids in efficacious amounts reduces the risk of oxidative stress- and chronic inflammation-mediated pathogenesis of human diseases such as cardiovascular disease, certain cancers, and neurological disorders. The physiological benefits of dietary flavonoids have been demonstrated to be due to multiple mechanisms of action, including regulating redox homeostasis, epigenetic regulations, activation of survival genes and signaling pathways, regulation of mitochondrial function and bioenergetics, and modulation of inflammation response. The role of flavonoids on gut microbiota and the impact of microbial metabolites of flavonoids on optimal health has begun to unravel. The complex physiological modulations of flavonoid molecules are due to their structural diversity. However, some flavonoids are not absorbed well, and their bioavailability could be enhanced through structural modifications and applications of nanotechnology, such as encapsulation. This Special Issue consists of four review articles on flavonoids and 15 original research articles, which cover the latest findings on the role of dietary flavonoids and their derivatives in disease prevention and treatment.
Systematic Screening Of Flavonoids Exerting Epo Regulatory Function In Neuronal Cells
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Author : Xuan Zheng
language : en
Publisher:
Release Date : 2016
Systematic Screening Of Flavonoids Exerting Epo Regulatory Function In Neuronal Cells written by Xuan Zheng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Erythropoietin categories.
Introduction To Flavonoids
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Author : Bohm
language : en
Publisher: CRC Press
Release Date : 1999-01-18
Introduction To Flavonoids written by Bohm and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-18 with Science categories.
Offering a wide ranging view of this important class of plant pigments, after a brief examination of the history & literature of flavonoids, this book explores structural variation of all subclasses of flavonoids, techniques for isolation, purification, & determination of structures, chemical syntheses, biosynthesis & genetics, patterns of distribution in the plant kingdom, & uses. Lastly, the functions of flavonoids in nature are investigated, as well as ways in which these compounds may have a more direct impact upon the human race. Contents: Introduction & Historical Perspective * Structural Variation * Occurrence & Distribution of Flavonoids * Extraction, Purification, & Identification of Flavonoids * Synthesis & Interconversions of Flavonoids * Biosynthesis & Genetics * Flavonoid Functions in Nature * Human Uses of Flavonoids