Fluorine Containing Amino Acids
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Fluorine Containing Amino Acids
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Author : Valery P. Kukhar
language : en
Publisher: John Wiley & Sons
Release Date : 1995-04-06
Fluorine Containing Amino Acids written by Valery P. Kukhar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-04-06 with Science categories.
In recent years, organo-fluorine chemistry has made a marked impact on the design and synthesis of a large variety of biologically active molecules, such as steroids, carbohydrates, amines, amino acids, peptides and other natural products. Naturally occurring amino acids play a pivotal role in living systems, and therefore synthetic fluorine-containing amino acids have been of significant interest to researchers working towards the understanding and modification of physiological processes. Fluorine-containing Amino Acids: is the first volume devoted to the synthesis and properties of fluorine-containing amino acids pays special attention to the preparation of enantiomerically pure acids (which are essential to the modern pharmaceutical industry) deals with a rapidly expanding field of research has been written by experienced researchers who are responsible for many developments in the field highlights the interdisciplinary nature of this topic Fluorine-containing Amino Acids is the only dedicated reference in this subject and will be essential for researchers in synthetic organic, peptide, natural product, and medicinal chemistry and biochemistry.
Fluorine In Pharmaceutical And Medicinal Chemistry
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Author : Véronique Gouverneur
language : en
Publisher: World Scientific
Release Date : 2012
Fluorine In Pharmaceutical And Medicinal Chemistry written by Véronique Gouverneur and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging. This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging.
Fluorine In Medicinal Chemistry And Chemical Biology
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Author : Iwao Ojima
language : en
Publisher: John Wiley & Sons
Release Date : 2009-03-23
Fluorine In Medicinal Chemistry And Chemical Biology written by Iwao Ojima and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-23 with Science categories.
The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: Discovery and development of fluorine containing drugs and drug candidates. New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates. Structural and chemical biology of fluorinated amino acids and peptides. Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis. Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.
Fluorine Containing Synthons
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Author : V. A. Soloshonok
language : en
Publisher:
Release Date : 2005
Fluorine Containing Synthons written by V. A. Soloshonok and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Science categories.
The book contains 35 top-notch chapter-reviews on recent methodological developments in the area of synthetic fluoro-organic chemistry based on fluorinated synthons approach. Special emphases are given to the synthesis of biologically relevant compounds (alcohols, amines, alpha- and beta-amino acids, peptides), industrial-scale production of highly versatile, synthetically useful fluorinated synthons, as well as asymmetric synthesis of fluorinated synthons. The book has been designed to be a comprehensive snap-shot of current research activity in the field reviewed by internationally renowned leading experts from academic and industrial laboratories around the world. The topics covered in the book range from synthesis of small fluorinated molecules to peptides and macromolecules for crystal engineering. Substantial amount of data reviewed in the book have never been published. In particular cutting-age technology from industrial laboratories, summarized in the book, will give the reader unprecedented prospective on commercial availability of variety of structurally diverse fluorinated synthons which will be on market in the nearest future. Taking into account the significant impact that fluorinated compounds have made on nearly all aspects of modern life this book is expected to be a current prime reference in the field and might be of interest to diverse readership.
Pharmacology Of Fluorides
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Author : Frank A. Smith
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-27
Pharmacology Of Fluorides written by Frank A. Smith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-27 with Medical categories.
This volume is the completion of work initially planned several years ago as a compilation of selected aspects of the biological effects of fluorides. The first portion appeared in Volume XXII (1966) of this Handbuch, under the title "Pharmacology of Fluorides, Part 1. " Inasmuch as the present volume is an integral part of the original project, justification for offering it to the scientific community remains the same as that originally set forth. This may be recapitulated as follows. The tremendous increase in the annual production of fluorides over the amounts produced thirty years ago, together with the increased diversity of their uses has correspondingly increased the hazard associated with these materials. That is to say, the possibilities of encountering their characteristic toxic effects under the conditions of their use has increased because the variety, amounts and ways of usage have increased. Their inherent toxicity, of course has not changed, but the increased hazard has led to a vast increase in the amount and scope of research reported. It is the purpose of these volumes to review selected aspects of this literature. Rochester, N. Y. , February 1970 FRANK A. SMITH Acknowledgements Even the casual reader of this volume will soon realize that contributing authors, as well as those contributing to its predecessor, Volume XX/I, have made good use of tables of data, figures and pertinent quotations from previously published work.
Biomedical Frontiers Of Fluorine Chemistry
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Author : Iwao Ojima
language : en
Publisher:
Release Date : 1996
Biomedical Frontiers Of Fluorine Chemistry written by Iwao Ojima and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
Developed from symposia sponsored by the Division of Fluorine Chemistry and the Division of Medicinal Chemistry.
Bioorganic And Medicinal Chemistry Of Fluorine
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Author : Jean-Pierre Bégué
language : en
Publisher: John Wiley & Sons
Release Date : 2008-06-02
Bioorganic And Medicinal Chemistry Of Fluorine written by Jean-Pierre Bégué and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-02 with Science categories.
Provides a thorough overview of the role of fluorine in pharmaceutical science and development Includes chapters on fluorinated analogues of natural products, fluorinated amino acids and peptides, and derivatives of sugars Classifies marketed and in-development fluorinated pharmaceuticals according to their therapeutic classes
Fluorine In Bioorganic Chemistry
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Author : John T. Welch
language : en
Publisher: Wiley-Interscience
Release Date : 1991-02-05
Fluorine In Bioorganic Chemistry written by John T. Welch and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-02-05 with Science categories.
Emphasizing structure, scope, and synthesis, as well as synthesis planning and methodology, it covers a wide variety of biologically active fluorine-containing compounds. A biological rationale is given for the design and biological fate of the described molecules.
Fluorine Chemistry V2
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Author : J.H. Simons
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Fluorine Chemistry V2 written by J.H. Simons and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Fluorine Chemistry, Volume II focuses on studies on fluorocarbons and fluorocarbon derivatives. Composed of various literature, the book first discusses fluorine-containing complex salts and acids. The complex fluorides of alkali metals, beryllium, boron, carbon, silicon, germanium, tin, and lead are described. The text also looks at research on halogen fluorides. The physical properties of chlorine, bromine, and iodine fluorides; halogen fluorides as ionizing solvents; and acids and bases in iodine pentafluoride and chlorine trifluoride are discussed. The book discusses analytical chemistry of fluorine and fluorine-containing compounds. Analysis of gaseous samples; separation and isolation of fluorine; qualitative detection and identification of fluorine; and determination of fluorine in specific materials are described. The text also focuses on organic compounds containing fluorine. Alcohols, acids and their derivatives, polymer containing fluorines, amines, amino acids, drugs, dyes, and pesticides are discussed as well. The book further looks at metallic compounds containing fluorocarbon radicals and organometallic compounds containing fluorine, fluorocarbon chemistry, and the infrared spectra of fluorocarbons and related compounds. The text is a vital source of information for readers wanting to study fluorocarbons and fluorocarbon derivatives.
Organofluorine Compounds
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Author : Tamejiro Hiyama
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Organofluorine Compounds written by Tamejiro Hiyama and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
In view of increasing interest in organofluorine compounds, this book was undertaken to describe biological and physical properties of organofluorine compounds, synthetic methods of these, their roles in pharmaceutical, agrochemical and material sciences. In particular, the book will emphasize on the usefulness of fluorination reaction, availability of fluorination agents, so that even graduate students who are unfamiliar to this field can understand and participate in this fascinating heteroatom chemistry.