Folding And Aggregation Studies In The Acylphosphatase Like Family
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Folding And Aggregation Studies In The Acylphosphatase Like Family
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Author : Francesco Bemporad
language : en
Publisher: Firenze University Press
Release Date : 2009
Folding And Aggregation Studies In The Acylphosphatase Like Family written by Francesco Bemporad and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Science categories.
Folding and misfolding of proteins are considered two sides of the same coin. The delicate equilibrium existing between these two processes is crucial for any living organism and its alterations can lead to the onset of several tremendous diseases, such as Alzheimer's and Parkinson's disease. The attainment of a profound knowledge of folding/misfolding processes is a key step to understand how life works and for discovering new therapies to these diseases. In this work the author shows that proteins can display enzymatic activity even in the absence of a compact three-dimensional structure, with important implications for the study of protein enzymes. Furthermore, the author investigates the formation of protein aggregates similar to those observed in patients of amyloid-related diseases.
Proteins As Possible Targets For Antitumor Metal Complexes Biophysical Studies Of Their Interactions
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Author : Chiara Gabbiani
language : en
Publisher: Firenze University Press
Release Date : 2009
Proteins As Possible Targets For Antitumor Metal Complexes Biophysical Studies Of Their Interactions written by Chiara Gabbiani and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Science categories.
There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents. Valuable structural and functional information on these adducts could be derived from several biophysical studies mainly relying on the application of X-ray diffraction and ESI MS techniques. The structural and functional information achieved on the respective metallodrug-protein adducts allowed us to identify some general trends in the reactivity of anticancer metallodrugs with protein targets.
Isotopic Fractionation Study Towards Massive Star Forming Regions Across The Galaxy
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Author : Laura Colzi
language : en
Publisher: Firenze University Press
Release Date : 2022
Isotopic Fractionation Study Towards Massive Star Forming Regions Across The Galaxy written by Laura Colzi and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Science categories.
One of the most important tools to investigate the chemical history of our Galaxy and our own Solar System is to measure the isotopic fractionation of chemical elements. In the present study new astronomical observations devoted to the study of hydrogen and nitrogen fractionation (D/H and 14N/15N ratios) of molecules, towards massive star-forming regions in different evolutionary phases, have been presented. Moreover, a new detailed theoretical study of carbon fractionation, 12C/13C ratios, has been done. One of the main results was the confirmation that the 14N/15N ratio increases with the galactocentric distance, as predicted by stellar nucleosynthesis Galactic chemical evolution models. This work gives new important inputs on the understanding of local chemical processes that favor the production of molecules with different isotopes in star-forming regions.
Determinants Of Mobility Disability In Older Adults Evidence From Population Based Epidemiologic Studies
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Author : Marco Inzitari
language : en
Publisher: Firenze University Press
Release Date : 2010
Determinants Of Mobility Disability In Older Adults Evidence From Population Based Epidemiologic Studies written by Marco Inzitari and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
Gait and mobility are cardinal to maintain autonomy and independency in daily life, also for older persons. Changes in these functions might be critical in the transition towards disability and loss of autonomy during the aging process. The aim of the present work, which collects three years of research conducted between Italy and the United States, was to assess some of the main risk factors for the progressive impairment of mobility and gait in older adults living in the community. According to our results, abnormalities in the nervous and cardiovascular systems, even subtle, are associated with a subsequent worsening of these functions. These data might help to better understand the progressive development of disability in the elderly, and in the future might also have practical implications for prevention.
Finite Size Effects In Stochastic Models Of Population Dynamics Applications To Biomedicine And Biology
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Author : Francesca Di Patti
language : en
Publisher: Firenze University Press
Release Date : 2010
Finite Size Effects In Stochastic Models Of Population Dynamics Applications To Biomedicine And Biology written by Francesca Di Patti and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Science categories.
Sub Wavelength Probing And Modification Of Complex Photonic Structures
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Author : Silvia Vignolini
language : en
Publisher: Firenze University Press
Release Date : 2010
Sub Wavelength Probing And Modification Of Complex Photonic Structures written by Silvia Vignolini and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Science categories.
The aim of this thesis consists in the study and modification of complex photonic nano-structures. Nowadays, propagation of light in such materials is a rich and fascinating area of research, both for its fundamental implications and for its practical technological impact. To deeply investigate light propagation inside these structures a high spatial resolution technique is required, especially because intriguing effects often occur on length scales comparable with the diffraction-limit or involve coupling phenomena on this length scale. For this reason in this thesis a Scanning Near-Field Optical Microscope represents one the most straightforward tool both to study and locally modify complex photonic nano-structures from perfect periodic to completely random ones.
Functional Validation Of Genetic Variants Identified By Next Generation Sequencing In Malformations Of Cortical Development
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Author : Dalila De Vita
language : en
Publisher: Firenze University Press
Release Date : 2022
Functional Validation Of Genetic Variants Identified By Next Generation Sequencing In Malformations Of Cortical Development written by Dalila De Vita and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Medical categories.
Malformations of cortical development (MCDs) result from a disruption in the process of the human brain cortex formation: currently, there are no pharmacological treatments for diffuse MCDs. Next-generation sequencing has accelerated the identification of MCDs causing genes: in some cases, functional studies are needed to clarify the role of genetic variants. The aim of this PhD project has been to apply a multidisciplinary approach to identify causative mutations in patients with MCDs, validate the pathogenic role of the identified mutations, and assess the effectiveness of novel in vitro treatment for mTOR pathway related MCDs.
Tectono Metamorphic Evolution Of The Continental Units Along The Edge Between Alpine And Hercynian Corsica
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Author : Maria Di Rosa
language : en
Publisher: Firenze University Press
Release Date : 2022
Tectono Metamorphic Evolution Of The Continental Units Along The Edge Between Alpine And Hercynian Corsica written by Maria Di Rosa and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Science categories.
In this work the central area of Corsica island was studied in order to reconstruct the tectono-metamorphic history of the continental and oceanic high pressure units that occupy the structurally deeper levels of the tectonic stacking of Alpine Corsica and their stratigraphic and structural relationship with the European margin (Hercynian Corsica). The study includes the geological mapping, the mesoscale and microscale structural analysis, the acquisition of chemical analyzes and micromaps with the microprobe, thermobarometric estimation through specific methodologies for metapelites, U-Th-Pb dating of zircons and allanites. The results obtained allows to reconstruct the geodynamic model of this sector of the Alpine belt from the Permian to the Burdigalian.
Bioinformatics Of Genome Evolution From Ancestral To Modern Metabolism Phylogenomics And Comparative Genomics To Understand Microbial Evolution
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Author : Marco Fondi
language : en
Publisher: Firenze University Press
Release Date : 2011
Bioinformatics Of Genome Evolution From Ancestral To Modern Metabolism Phylogenomics And Comparative Genomics To Understand Microbial Evolution written by Marco Fondi and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
Bioinformatics, that is the interdisciplinary field that blends computer science and biostatistics with biological and biomedical sciences, is expected to gain a central role in next feature. Indeed, it has now affected several fields of biology, providing crucial hints for the understanding of biological systems and also allowing a more accurate design of wet lab experiments. In this work, the analysis of sequence data has be used in different fields, such as evolution (e.g. the assembly and evolution of metabolism), infections control (e.g. the horizontal flow of antibiotic resistance), ecology (bacterial bioremediation).
An Integrated Nonlinear Wind Waves Model For Offshore Wind Turbines
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Author : Enzo Marino
language : en
Publisher: Firenze University Press
Release Date : 2010
An Integrated Nonlinear Wind Waves Model For Offshore Wind Turbines written by Enzo Marino and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Coastal engineering categories.
This thesis presents a numerical model capable of simulating offshore wind turbines exposed to extreme loading conditions. External condition-based extreme responses are reproduced by coupling a fully nonlinear wave kinematic solver with a hydro-aero-elastic simulator. First, a two-dimensional fully nonlinear wave simulator is developed. The transient nonlinear free surface problem is formulated assuming the potential theory and a high-order boundary element method is implemented to discretize Laplace's equation. For temporal evolution a second-order Taylor series expansion is used. The code, after validation with experimental data, is successfully adopted to simulate overturning plunging breakers which give rise to dangerous impact loads when they break against wind turbine substructures. Emphasis is then placed on the random nature of the waves. Indeed, through a domain decomposition technique a global simulation framework embedding the numerical wave simulator into a more general stochastic environment is developed. The proposed model is meant as a contribution to meet the more and more pressing demand for research in the offshore wind energy sector as it permits taking into account dangerous effects on the structural response so as to increase the global structural safety level.