From Chromosomes To Mobile Genetic Elements
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From Chromosomes To Mobile Genetic Elements
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Author : Lee B. Kass
language : en
Publisher: CRC Press
Release Date : 2024-06-27
From Chromosomes To Mobile Genetic Elements written by Lee B. Kass and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-27 with Science categories.
This biography of Nobel Laureate Barbara McClintock (1902-1992) places her life and work in its social, scientific and personal context. The author examines the development of Barbara McClintock’s scientific work and her influence upon individuals and upon the fields of cytogenetics and evolutionary biology in the period from 1902 to the present. The history documents years of McClintock’s notable and lauded scientific work long before she discovered and named transposable elements in the mid-1940s for which she ultimately received the Nobel Prize. The biography employs documented evidence to expose, demystify, and provide clarity for legends and misinterpretations of McClintock’s life and work. Key Features Exposes and demystifies myths and legends told about McClintock’s time in Missouri Clarifies the changing language of genes and genetics Places in perspective the history of McClintock’s research Documents McClintock’s family and early life before college Provides documented details of McClintock’s time in Nazi Germany
Mobile Genetic Elements In Metazoan Parasites
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Author : Paul J. Brindley
language : en
Publisher: CRC Press
Release Date : 2009-10-28
Mobile Genetic Elements In Metazoan Parasites written by Paul J. Brindley and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-28 with Science categories.
Substantial proportions of the genome of most eukaryotes, including those of metazoan parasites, are comprised of repetitive sequences. Mobile genetic elements (MGEs) constitute much of the repetitive component, particularly the interspersed sequences. This volume of nine chapters addresses MGEs that have colonized the genomes of medically important metazoan parasites and their vectors. These MGEs are parasites of parasites. These mobile elements are compared and contrasted with those from better-studied model organisms. The authors have included plentiful, relevant, and informative illustrations and references. Several chapters focus on mobile elements of the human schistosomes. Gerardo Ferbeyre focuses on the putative ribozyme activities on the SM alpha elements, SINE-like elements, including trans reactions catalyzed by these retroposons. Ricardo DeMarco and Sergio Verjovski-Almeida review the cut-and-paste transposons of schistosomes, including the Merlin and the SmTRC1 elements, and application of schistosome DNA transposons to transgenesis and mutagenesis. Claudia Copeland, Thewarach Laha and I review the retrovirus-like retrotransposons and non-long terminal repeat transposable elements of the schistosomes, including the Boudicca, fugitive and SR2 elements. Young-An Bae and Yoon Kong provide descriptions of retrotransposons from the human liver and lung flukes, Clonorchis sinensis and Paragonimus westermani, respectively, including the CsRn1 long terminal repeat retrotransposon. Continuing the investigations of MGEs of parasitic worms, Thewarach Laha, Alex Loukas and I summarize current knowledge of MGEs from hookworms, including details of the bandit and Transib transposons and dingo retrotransposons. Mobile elements in vectors of human parasites are also covered. Matty Knight and coauthors describe the nimbus retrotransposon and its discovery and other repetitive elements from the genome of the gastropod snail Biomphalaria glabrata, the intermediate host of Schistosoma mansoni. Zhijian Tu and Song Ti review MGEs of Anopheles mosquitoes, vectors of malaria, and other mosquitoes. They discuss practical uses of these MGEs. Craig Coates provides an expert article on transposon mediated transgenesis of mosquitoes, in particular dealing with his pioneering studies on the deployment of binary systems with the Mos1 mariner transposon. MGEs from the genomes of these metazoan parasites have practical uses in transgenesis and epidemiological studies and also are valuable for annotation of the genomes of these vectors and pathogens. These issues and future directions are well covered in these chapters.
Mobile Genetic Elements
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Author : James Shapiro
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Mobile Genetic Elements written by James Shapiro and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Mobile Genetic Elements introduces the nonspecialist to the biology and genetics of mobile elements. It attempts to make the biochemistry of DNA rearrangements more accessible to embryologists and evolutionists, and to illuminate the related developmental cycles to the biochemist. The book also shows how natural the activity of mobile elements can be in diverse biological situations. The chapters describe several well-studied cases in which genetic determinants—often identified as specific nucleic acid sequences—repeatedly change their positions within or between cellular genomes. Because their genomic positions are not fixed, these determinants may conveniently be classed together under the rubric of mobile genetic elements. The book begins with a discussion of maize controlling elements. This is followed by separate chapters on the bacteriophages ? and Mu; nonviral mobile elements in bacteria; transposable Ty elements in brewer's yeast; Drosophila transposable element; and hybrid dysgenesis. Subsequent chapters cover vertebrate retroviruses; Agrobacterium oncogenesis in plants; flagellar phase variation in Salmonella; yeast mating type; and surface antigenic variation in trypanosomes.
From Chromosomes To Mobile Genetic Elements
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Author : Lee B. Kass
language : en
Publisher:
Release Date : 2024
From Chromosomes To Mobile Genetic Elements written by Lee B. Kass and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024 with Cytogenetists categories.
"This biography of Nobel Laureate Barbara McClintock (1902-1992) places her life and work in its social, scientific and personal context. The author examines the development of Barbara McClintock's scientific work and her influence upon individuals and upon the fields of cytogenetics and evolutionary biology in the period from 1902 to the present. The history documents years of McClintock's notable and lauded scientific work long before she discovered Transposable Elements in the mid-1940s for which she ultimately received the Nobel Prize. The biography employs documented evidence to expose, demystify, and provide clarity for legends and misinterpretations of McClintock's life and work"--
Mobile Genetic Elements
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Author : Wolfgang J. Miller
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-05
Mobile Genetic Elements written by Wolfgang J. Miller and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-05 with Medical categories.
Leading experts describe in step-by-step detail their most productive transposon-based methods and strategies for studying genome structure, function, and evolution. These readily reproducible techniques cover a wide range, including mutagenesis, transgenesis, gene silencing, and molecular systematics. Among the highlights are a series of DNA hybridization methods for analyzing the distribution and dynamics of mobile DNA at the hosts' genomic level, techniques for studying LTR retrotransposons in heterologous host systems, and mutagenesis protocols for investigating gene functions in a broad range of organisms. These cutting-edge methods offer investigators powerful genetic tools for dissecting the function of a specific gene, elaborating on the mechanisms leading to genetic change and diversity, and studying the evolutionary impact of mobile DNA on the biology and evolution of organisms.
Bacterial Integrative Mobile Genetic Elements
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Author : Adam P. Roberts
language : en
Publisher: CRC Press
Release Date : 2022-03-07
Bacterial Integrative Mobile Genetic Elements written by Adam P. Roberts and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-07 with Science categories.
As our understanding of mobile genetic elements continues to grow we are gaining a deeper appreciation of their importance in shaping the bacterial genome and in the properties they confer to their bacterial hosts. These include, but are by no means limited to, resistance to antibiotics, and heavy metals, toxin production and increased virulence, production of antibiotics and the ability to utilize a diverse range of metabolic substrates. We are also gaining an understanding of diversity of these elements and their interactions with each other; a property which continually complicates any attempt to classify them. We are learning more about the molecular mechanisms by which they translocate to new genomic sites both within genomes and between different bacteria. This book provides a timely, state of the art update on the properties of an important selection of different bacterial integrative mobile genetic elements and the myriad of different ways in which they move and influence the biology of the host bacterium. The chapters are all written by authors who have undertaken pioneering work in their respective fields, making this book vital reading for all who are interested in the biology of bacteria and the mobile elements they carry.
Genes Genomes Genetics And Chromosomes
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Author : Logan Aguilar
language : en
Publisher: Scientific e-Resources
Release Date : 2019-09-03
Genes Genomes Genetics And Chromosomes written by Logan Aguilar and has been published by Scientific e-Resources this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-03 with categories.
A genome is an organism's complete set of DNA, including all of its genes. Each genome contains all of the information needed to build and maintain that organism. In humans, a copy of the entire genome-more than three billion DNA base pairs-is contained in all cells that have a nucleus. Developmental Genetics studies how the genes regulate developmental changes in behavior and influence scientific approaches in several fields. It highlights the interdisciplinary approach of developmental genetics with new revolutionary technologies and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. Chromosomes come in matching sets of two (or pairs) and there are hundreds-sometimes thousands-of genes in just one chromosome. The chromosomes and genes are made of DNA, which is short for deoxyribonucleic. Genes, Genomes, and Genomics, with chapters written by internationally renowned experts, provide an enormous reservoir of new information in the various theoretical and applied aspects of unravelling the secrets hidden in the genes of plants, animals and microorganisms. A gene is the basic physical and functional unit of heredity. Genes, which are made up of DNA, act as instructions to make molecules called proteins. In humans, genes vary in size from a few hundred DNA bases to more than two million bases. Moreover, the book presents a thorough overview of a wide array of methodologies from classical genetics to modern genomics technologies.
Mobile Dna Iii
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Author : Michael Chandler
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-24
Mobile Dna Iii written by Michael Chandler and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-24 with Science categories.
An exploration of the raw power of genetic material to refashion itself to any purpose... Virtually all organisms contain multiple mobile DNAs that can move from place to place, and in some organisms, mobile DNA elements make up a significant portion of the genome. Mobile DNA III provides a comprehensive review of recent research, including findings suggesting the important role that mobile elements play in genome evolution and stability. Editor-in-Chief Nancy L. Craig assembled a team of multidisciplinary experts to develop this cutting-edge resource that covers the specific molecular mechanisms involved in recombination, including a detailed structural analysis of the enzymes responsible presents a detailed account of the many different recombination systems that can rearrange genomes examines the tremendous impact of mobile DNA in virtually all organisms Mobile DNA III is valuable as an in-depth supplemental reading for upper level life sciences students and as a reference for investigators exploring new biological systems. Biomedical researchers will find documentation of recent advances in understanding immune-antigen conflict between host and pathogen. It introduces biotechnicians to amazing tools for in vivo control of designer DNAs. It allows specialists to pick and choose advanced reviews of specific elements and to be drawn in by unexpected parallels and contrasts among the elements in diverse organisms. Mobile DNA III provides the most lucid reviews of these complex topics available anywhere.
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2004
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.
Mobile Genetic Elements In Cellular Differentiation Genome Stability And Cancer
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Author : Tammy A. Morrish
language : en
Publisher: Frontiers Media SA
Release Date : 2018-01-16
Mobile Genetic Elements In Cellular Differentiation Genome Stability And Cancer written by Tammy A. Morrish and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-16 with categories.
The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS). To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer.