Function And Flexibility Friend Or Foe

DOWNLOAD

Download Function And Flexibility Friend Or Foe PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Function And Flexibility Friend Or Foe book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Function And Flexibility Friend Or Foe

DOWNLOAD
Author : Kris Pauwels
language : en
Publisher: Frontiers Media SA
Release Date : 2016-10-06

Function And Flexibility Friend Or Foe written by Kris Pauwels and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-06 with Science (General) categories.

Louis Sullivan (1856 - 1924) revolutionized architecture by designing the first skyscraper and he became famous by proclaiming that “form follows function”. When x-ray crystallographers visualized the structures of proteins for the first time, the structural biology field embraced the view that “function follows form” as the 3D-architecture of proteins could unveil various aspects of their function. Despite the original “1 gene - 1 protein structure - 1 function” relationship, nowadays a far more complicated picture emerges where the flexibility and dynamics of a protein can play a central role in a multitude of functions. The ultimate form(s) that a protein adopt when interacting with (a) partner molecule(s) are the most biologically relevant and in this context Sullivan’s quote is still appropriate: the conformation that the protein adopts follows from the function of that protein. Despite the fact that many well-characterized proteins have a well-folded structure, there is a growing interest in the conformational flexibility within proteins. This flexibility is also a balanced phenomenon: excess of flexibility can be detrimental for protein behaviour, as well as the lack thereof. Notwithstanding its importance, studying intrinsically disordered protein regions or conformational rearrangements can be a very challenging. Therefore, flexibility can be perceived as a friend or a foe, depending on the context. This e-book showcases the impact of the study of protein flexibility on the structural biology field and presents protein flexibility in the context of disease as well as its benign aspects. As detailed knowledge of the structural aspects of polypeptides remains essential to comprehend protein function, one of the future challenges for structural biology also lies with large macromolecular protein complexes. Also there the dynamics and flexibility are essential for proper functioning and molecular movement, which is an important aspect of living matter. This challenge stimulated the development of advanced techniques to study protein flexibility and the use of those techniques to address fundamental biological and biomedical problems. Those innovations should help us to unravel the intimate link between protein function and flexibility and explore new horizons.

Weak Interactions In Molecular Machinery

DOWNLOAD
Author : Irene Díaz-Moreno
language : en
Publisher: Frontiers Media SA
Release Date : 2019-03-20

Weak Interactions In Molecular Machinery written by Irene Díaz-Moreno and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-20 with categories.

Diverse cellular processes depend on weak interactions between biological components. In this volume, we bring together a wealth of recent information on this topic, combining original research articles with up-to-date reviews, organized under four separate themes. In our first section on nucleic acid regulation, we include a study of the PII-NAGK-PipX-NtcA regulatory axis of cyanobacteria and discover much about the role of RNA binding protein regulation and cross-talk in the control of AU-rich mRNA. Peptide-mediated weak interactions are our second theme in which we review weak molecular interactions in clathrin-mediated endocytosis, investigate the selectivity of the G7-18NATE inhibitor peptide for the Grb7-SH2 domain target and present new structure and interactions of the TPR domain of Sgt2 with yeast chaperones and Ybr137wp. Our third part focuses on carbohydrates and includes a thorough review of how to use NMR to study transient carbohydrate - protein binding and a structural and functional study of lysostaphin - substrate interaction. In our final section, we look at functional sensors driving weak interactions by presenting the molecular basis of the dual regulation of bacterial iron sulfur cluster biogenesis by CyaY and IscX alongside a review of intramolecular fuzzy interactions involving intrinsically disordered domains. Taken together, our eBook chapters offer some recent insight into this area of scientific understanding which is still expanding exponentially.

Tgf In Human Disease Friend Or Foe

DOWNLOAD
Author : Guoping Zheng
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-26

Tgf In Human Disease Friend Or Foe written by Guoping Zheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Science categories.

Flexible Work Arrangements Conceptualizations And International Experiences

DOWNLOAD
Author : Isik U. Zeytinoglu
language : en
Publisher: Springer
Release Date : 2002-12-18

Flexible Work Arrangements Conceptualizations And International Experiences written by Isik U. Zeytinoglu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12-18 with Business & Economics categories.

Examines the effect of flexible work arrangements on individusls' career, family, health and well-being, as well as effects on the workplace and the society.

The Human Microbiome In Health And Disease

DOWNLOAD
Author : Margaret Riley
language : en
Publisher: Princeton University Press
Release Date : 2025-12-09

The Human Microbiome In Health And Disease written by Margaret Riley and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-12-09 with Science categories.

How the trillions of microbes in our bodies influence nearly every aspect of our health Each of our bodies is home to trillions of microorganisms that shape our health, prevent disease, and influence conditions ranging from depression to allergies. This book offers a detailed look at how our microbial inhabitants—known as the microbiome—affect almost every facet of our health. It takes readers from the microbiome’s primordial origins and their symbiosis with humans to the latest microbiome research, utilizing real-world case studies and current clinical insights to show how shifts in the microbiome can play a role in obesity, autoimmune disorders, depression, and other conditions. Each chapter incorporates cutting-edge research findings, exploring both traditional and new therapeutic approaches to restoring microbiome balance. The text emphasizes the interactions between diet and microbiome health, showing how personalized dietary choices can serve as preventive and therapeutic tools, and describes emerging microbiome-based diagnostics and treatments. • Fills the need for an introductory textbook on the human microbiome • Presents complex information in an accessible way, with illustrations, summaries, and key takeaways • Integrates research and examples • Draws on the author’s years of undergraduate teaching experience

Encyclopedia Of The Mind

DOWNLOAD
Author : Harold Pashler
language : en
Publisher: SAGE
Release Date : 2013-01-14

Encyclopedia Of The Mind written by Harold Pashler and has been published by SAGE this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-14 with Language Arts & Disciplines categories.

It's hard to conceive of a topic of more broad and personal interest than the study of the mind. In addition to its traditional investigation by the disciplines of psychology, psychiatry, and neuroscience, the mind has also been a focus of study in the fields of philosophy, economics, anthropology, linguistics, computer science, molecular biology, education, and literature. In all these approaches, there is an almost universal fascination with how the mind works and how it affects our lives and our behavior. Studies of the mind and brain have crossed many exciting thresholds in recent years, and the study of mind now represents a thoroughly cross-disciplinary effort. Researchers from a wide range of disciplines seek answers to such questions as: What is mind? How does it operate? What is consciousness? This encyclopedia brings together scholars from the entire range of mind-related academic disciplines from across the arts and humanities, social sciences, life sciences, and computer science and engineering to explore the multidimensional nature of the human mind.

Flow Cytometry

DOWNLOAD
Author : Zbigniew Darzynkiewicz
language : en
Publisher: Academic Press
Release Date : 1994

Flow Cytometry written by Zbigniew Darzynkiewicz and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Cell separation categories.

Function And Flexibility Friend Or Foe

DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2016

Function And Flexibility Friend Or Foe written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.

Louis Sullivan (1856 - 1924) revolutionized architecture by designing the first skyscraper and he became famous by proclaiming that "form follows function". When x-ray crystallographers visualized the structures of proteins for the first time, the structural biology field embraced the view that "function follows form" as the 3D-architecture of proteins could unveil various aspects of their function. Despite the original "1 gene - 1 protein structure - 1 function" relationship, nowadays a far more complicated picture emerges where the flexibility and dynamics of a protein can play a central role in a multitude of functions. The ultimate form(s) that a protein adopt when interacting with (a) partner molecule(s) are the most biologically relevant and in this context Sullivan's quote is still appropriate: the conformation that the protein adopts follows from the function of that protein. Despite the fact that many well-characterized proteins have a well-folded structure, there is a growing interest in the conformational flexibility within proteins. This flexibility is also a balanced phenomenon: excess of flexibility can be detrimental for protein behaviour, as well as the lack thereof. Notwithstanding its importance, studying intrinsically disordered protein regions or conformational rearrangements can be a very challenging. Therefore, flexibility can be perceived as a friend or a foe, depending on the context. This e-book showcases the impact of the study of protein flexibility on the structural biology field and presents protein flexibility in the context of disease as well as its benign aspects. As detailed knowledge of the structural aspects of polypeptides remains essential to comprehend protein function, one of the future challenges for structural biology also lies with large macromolecular protein complexes. Also there the dynamics and flexibility are essential for proper functioning and molecular movement, which is an important aspect of living matter. This challenge stimulated the development of advanced techniques to study protein flexibility and the use of those techniques to address fundamental biological and biomedical problems. Those innovations should help us to unravel the intimate link between protein function and flexibility and explore new horizons.

Functions And Basic Doctrine Of The United States Air Force

DOWNLOAD
Author :
language : en
Publisher:
Release Date : 1984

Functions And Basic Doctrine Of The United States Air Force written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with categories.

Total Integrated Marketing

DOWNLOAD
Author : James M. Hulbert
language : en
Publisher: Kogan Page Publishers
Release Date : 2005

Total Integrated Marketing written by James M. Hulbert and has been published by Kogan Page Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Business & Economics categories.

Based on their combined experience of over half a century of advising companies, the authors argue that marketing has lost its way. Companies cannot win in today's highly competitive markets by leaving marketing up to the marketing department. Success in the new marketplace demands integration of the firm's entire set of capabilities into a seamless system that delivers exemplary customer satisfaction, if not delight. Integrating marketing is imperative, from the top down, and with every major function: finance, operations, sales, R&D, customer service and HR. Only by creating Total Integrated Marketing, ensuring that everyone in the organization has one paramount goal to get and keep customers can success be achieved. The authors provide a wealth of marketing tips and innovations that readers can easily adapt to their own businesses and revealing cases that lift the lid on good and bad practice around the world.