G Protein Coupled Transmembrane Signaling Mechanisms
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G Protein Coupled Transmembrane Signaling Mechanisms
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Author : Robert R. Ruffolo
language : en
Publisher: CRC Press
Release Date : 1995-01-09
G Protein Coupled Transmembrane Signaling Mechanisms written by Robert R. Ruffolo and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-01-09 with Medical categories.
This book discusses recent major advances made in the molecular biology, signal transduction processes, pharmacology, and therapeutic applications of key receptors and receptor systems.
Functioning Of Transmembrane Receptors In Signaling Mechanisms
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Author : Ralph A. Bradshaw
language : en
Publisher: Academic Press
Release Date : 2011-04-05
Functioning Of Transmembrane Receptors In Signaling Mechanisms written by Ralph A. Bradshaw and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-05 with Science categories.
A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation. Articles written and edited by experts in the field Thematic volume covering effectors, cytosolic events, nuclear, and cytoplasmic events Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease
Signal Transduction Pathways Mechanisms And Diseases
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Author : Ari Sitaramayya
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-02
Signal Transduction Pathways Mechanisms And Diseases written by Ari Sitaramayya and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-02 with Science categories.
Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.
G Protein Signaling Mechanisms In The Retina
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Author : Kirill A. Martemyanov
language : en
Publisher: Springer
Release Date : 2014-09-04
G Protein Signaling Mechanisms In The Retina written by Kirill A. Martemyanov and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-04 with Medical categories.
The main purpose of this volume is to provide a focused analysis of the function of the G protein-coupled signaling pathways that operate in the interconnected network of retinal neurons as they detect and encode the information carried by light. The organization of this volume will generally follow the path of signal flow in the retina. First we will describe recent advances in understanding the phototransduction cascade of rod and cone photoreceptors, which use signaling cascade based on the GPCR rhodopsin to transduce incident light into neural activity. Chapters will be devoted to unique specializations of the two major types of photosensitive cells that comprise the predominant input for our spatial and color vision. Subsequently, the mechanisms of synaptic information encoding by retinal ON bipolar cells will be described, where the GPCR mGluR6 plays a fundamental role. Chapters in this section will examine macromolecular organization of the mGluR6 signaling pathway as well as current understanding of its function. The functional characteristics of this signaling mechanism will be explored in detail. Additionally, this section will cover the role of dopamine receptors in modulating signal transmission between photoreceptors and ON-bipolar cells. Finally, chapters will be focused on the output neurons of the inner retina, ganglion cells, where the components of the emerging GPCR melanopsin cascade in intrinsically photosensitive ganglion cells will be detailed. Collectively these mechanisms allow the retina to represent visual space over a wide range of light intensities.
G Protein Coupled Receptors Signaling Mechanisms And Pathophysiological Relevance
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Author : Pablo V. Escribá
language : en
Publisher:
Release Date : 2007
G Protein Coupled Receptors Signaling Mechanisms And Pathophysiological Relevance written by Pablo V. Escribá and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Signal Transduction By G Protein Coupled Receptors
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Author : Paul H.J. Nederkoorn
language : en
Publisher: Springer
Release Date : 1997-02-15
Signal Transduction By G Protein Coupled Receptors written by Paul H.J. Nederkoorn and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-02-15 with Medical categories.
PROCESS OPTIMIZATION: A Statistical Approach is a textbook for a course in experimental optimization techniques for industrial production processes and other "noisy" systems where the main emphasis is process optimization. The book can also be used as a reference text by Industrial, Quality and Process Engineers and Applied Statisticians working in industry, in particular, in semiconductor/electronics manufacturing and in biotech manufacturing industries. The major features of PROCESS OPTIMIZATION: A Statistical Approach are: It provides a complete exposition of mainstream experimental design techniques, including designs for first and second order models, response surface and optimal designs; Discusses mainstream response surface method in detail, including unconstrained and constrained (i.e., ridge analysis and dual and multiple response) approaches; Includes an extensive discussion of Robust Parameter Design (RPD) problems, including experimental design issues such as Split Plot designs and recent optimization approaches used for RPD; Presents a detailed treatment of Bayesian Optimization approaches based on experimental data (including an introduction to Bayesian inference), including single and multiple response optimization and model robust optimization; Provides an in-depth presentation of the statistical issues that arise in optimization problems, including confidence regions on the optimal settings of a process, stopping rules in experimental optimization and more; Contains a discussion on robust optimization methods as used in mathematical programming and their application in response surface optimization; Offers software programs written in MATLAB and MAPLE to implement Bayesian and frequentist process optimization methods; Provides an introduction to the optimization of computer and simulation experiments including and introduction to stochastic approximation and stochastic perturbation stochastic approximation (SPSA) methods; Includes an introduction to Kriging methods and experimental design for computer experiments; Provides extensive appendices on Linear Regression, ANOVA, and Optimization Results.
Pharmacology Of G Protein Coupled Receptors
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Author : Richard R. Neubig
language : en
Publisher: Academic Press
Release Date : 2011-09-19
Pharmacology Of G Protein Coupled Receptors written by Richard R. Neubig and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-19 with Medical categories.
G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones. In addition, emerging drug targets such as receptor families for fatty acids, carboxylic acids, lipid mediators, etc. are included. Final chapters cover novel mechanisms of signal regulation through PDZ domains and RGS proteins. This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists
The G Protein Coupled Receptors Handbook
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Author : Lakshmi A. Devi
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-03-01
The G Protein Coupled Receptors Handbook written by Lakshmi A. Devi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-01 with Medical categories.
A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.
G Protein Coupled Receptors Part B
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-01-25
G Protein Coupled Receptors Part B written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-25 with Science categories.
G Protein-Coupled Receptors, Part B, Volume 195 represents the largest class of cell H103 surface proteins that have intricate involvement in nearly every physiological process in our body. Approximately one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. Sections in this volume include Adhesion G protein-coupled receptors: Structure and functions, Molecular and cellular mechanisms underlying brain region-specific cannabinoid receptor modulation by estradiol across the rodent estrus cycle, Probing the orphan receptors: Tools and directions, Asymmetric activation of Class C GPCRs, Common and selective signal transduction mechanisms of GPCRs, and much more. Covers a broad range of topics related to GPCR activation and signaling Provides several receptor systems, with an emphasis on emerging paradigms Includes different processes and model systems, with a focus on GPCRs
Allosteric Modulation Of G Protein Coupled Receptors
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Author : Robert Laprairie
language : en
Publisher: Academic Press
Release Date : 2022-02-05
Allosteric Modulation Of G Protein Coupled Receptors written by Robert Laprairie and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-05 with Business & Economics categories.
Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not – as we once believed – unique to a few receptor subfamilies. Introduces background on core concepts of molecular pharmacology, including statistical analyses, non-linear regression, complex models and GPCR-dependent signal transduction as they relate to allosteric modulation Discusses critical advances and landmark studies, including discoveries in the area of GPCR allosteric modulation, which are reviewed for their importance in positive and negative regulation, protein-protein interactions, and small molecule drug discovery Includes key methodologies used to study allosteric modulation at the in silico, in vitro, and in vivo levels of drug discovery and characterization