Gabab Receptor
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Gabab Receptor Pharmacology A Tribute To Norman Bowery
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-09-21
Gabab Receptor Pharmacology A Tribute To Norman Bowery written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-21 with Medical categories.
This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABAB receptor. In the present volume, leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational, in the discovery of drugs acting at the GABAB receptor. The topics covered provide a comprehensive review of the field and the current state of research in this area. Included are chapters on the chemistry of GABAB agonists and antagonists, on the genetics and molecular composition of the site, its regulation and trafficking, and its role in controlling cellular, autonomic, and behavioral function. There are also chapters describing the potential clinical utility of drugs regulating GABAB activity receptor in the areas of hypertension, gastroesophageal reflux disease, Down syndrome, depression, and substance abuse. The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular. Articles written by leading investigators in the field Informs and updates on all the latest developments
Gabab Receptor
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Author : Giancarlo Colombo
language : en
Publisher: Springer
Release Date : 2016-12-19
Gabab Receptor written by Giancarlo Colombo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-19 with Medical categories.
An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.
Behavioral Neurobiology Of Gabab Receptor Function
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Author : Styliani Vlachou
language : en
Publisher: Springer Nature
Release Date : 2022-01-01
Behavioral Neurobiology Of Gabab Receptor Function written by Styliani Vlachou and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-01 with Medical categories.
It has been almost forty years since Norman G. Bowery discovered and named this “non-GABAA” receptor the GABAB receptor. It has been almost ten years since the last comprehensive book presentation focused on GABAB receptors. The main goal of this book is to provide the field with a contemporary and comprehensive perspective on the GABAB receptor, its physiological relevance, and its therapeutic potential. The volume is organized into introductory and special interest sections presented by experts who study the GABAB receptor from structural, signaling, pharmacologic, physiological, pathophysiological, and therapeutic perspectives. The book aims to appeal to a broad spectrum of biomedical and clinical scientists - any scholars with an interest in GABAB receptor. The editors hope readers find this work to be thought-provoking, instructive, and informative.
Gabab Receptor Pharmacology A Tribute To Norman Bowery
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-08-18
Gabab Receptor Pharmacology A Tribute To Norman Bowery written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-18 with Medical categories.
This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABAB receptor. In the present volume, leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational, in the discovery of drugs acting at the GABAB receptor. The topics covered provide a comprehensive review of the field and the current state of research in this area. Included are chapters on the chemistry of GABAB agonists and antagonists, on the genetics and molecular composition of the site, its regulation and trafficking, and its role in controlling cellular, autonomic, and behavioral function. There are also chapters describing the potential clinical utility of drugs regulating GABAB activity receptor in the areas of hypertension, gastroesophageal reflux disease, Down syndrome, depression, and substance abuse. The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular. Articles written by leading investigators in the field Informs and updates on all the latest developments
Extrasynaptic Gabaa Receptors
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Author : Adam C. Errington
language : en
Publisher: Springer
Release Date : 2014-09-22
Extrasynaptic Gabaa Receptors written by Adam C. Errington and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-22 with Medical categories.
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.
The Gaba Receptors
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Author : Salvatore J. Enna
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-17
The Gaba Receptors written by Salvatore J. Enna and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-17 with Medical categories.
The Gaba Receptors, Third Edition, presents a critical appraisal of our current understanding of the molecular, behavioral, biochemical, clinical, and pharmacological properties of GABA receptors. Emphasis is placed on exploring cutting-edge findings on the structureal properties of receptor sites, mechanisms of receptor expression, chemical agents that differentiate receptor subtypes, and phenotypes displayed by GABA receptor null mice. Chapters in this updated and expanded edition examine such topics as GABA receptor subypes, trafficking postsynaptic GABA receptors, GABA receptor mutations associated with idiopathic generalized epilepsies and febrile seizures, and GABA receptors as a potential therapeutic target.
Gaba Receptors Transporters And Metabolism
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Author : Chikako Tanaka
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06
Gaba Receptors Transporters And Metabolism written by Chikako Tanaka and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Highlighting the current developments and future directions in GABA research, the ambitious aim of this topical volume is to cover GABA from the molecular mechanisms of its transmission to new targets for pharmaceutical research. Distinguished scientists at the forefront of GABA research were invited to contribute reviews on glutamate decarboxylase and autoimmunity, molecular structure and functional regulation of GABA transporters, transmitter release and GABA receptor regulation, GABA receptor subtypes and functional regulation, and GABA receptor ligands and their therapeutic application. Describing the latest advances in what has become a rapidly-evolving field, this volume will prove immensely valuable to neuroscientists, pharmacologists, biochemists, and physiologists working in the field of GABA research.
Benzodiazepine Gaba Receptors And Chloride Channels
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Author : Richard W. Olsen
language : en
Publisher:
Release Date : 1986
Benzodiazepine Gaba Receptors And Chloride Channels written by Richard W. Olsen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.
The fifth volume in the series is the first to deal exclusively with a single type of receptor. Contributions represent the most up-to-date research in the benzodiazepine/GABA receptor-chloride channel complex, an extremely interesting protein of great neurobiological significance. Major workers in the field describe the history of GABA receptors and the benzodiazepine connection''. Lays out background material in a particularly clear fashion to allow readers from outside the field to quickly grasp the main points. Presents in detail the allosteric interactions between the various components of the benzodiazepine/GABA receptor complex from the points of view of several authors, so that readers can choose their level of involvement with these details. Includes the most recent advances on the biochemical purification, characterization, and development of monoclonal antibodies for the benzodiazepine/GABA receptor protein.
Role Of Gabab Receptor
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Author : 吳芮妮
language : en
Publisher:
Release Date : 2016
Role Of Gabab Receptor written by 吳芮妮 and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Gamma Hydroxybutyrate
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Author : Godfrey Tunnicliff
language : en
Publisher: CRC Press
Release Date : 2002-08-01
Gamma Hydroxybutyrate written by Godfrey Tunnicliff and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-08-01 with Medical categories.
Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state and from its use in general anaesthesia in human subjects. It has been found to be a naturally-occurring compound in the brain, a metabolite of GABA, the emerging ubiquitous inhibitory neurotransmitter. This has opened