Gamma Delta T Cells
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Gamma Delta T Cells
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Author : Paul R. Bergstresser
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2001-01-01
Gamma Delta T Cells written by Paul R. Bergstresser and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-01 with Medical categories.
Over the last 15 years, since the discovery of the T cell receptor and genes, rapid progress has been made toward the understanding of the biology of T cells. They differ from conventional T cells not only in T cell receptor composition, but also in their development, tissue distribution, and physiological functions. This volume contains seven chapters contributed by experts on different aspects of T cells, including the natural ligands for T cell receptors, IL-7-dependent regulation of T cell development, cytokine-mediated inter-cellular communication of T cells with other cell types, and their physiological functions in innate and adaptive immune responses. The comprehensive review articles collected in this volume will be of interest to basic immunologists who wish to update their knowledge on the biology of T cells. The book also provides a unique opportunity for non-immunologists and clinicians to understand how the immune system is specifically equipped to protect the body against pathogens at the environmental interface.
Understanding Gamma Delta T Cell Multifunctionality Towards Immunotherapeutic Applications
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Author : Kenth Gustafsson
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-02
Understanding Gamma Delta T Cell Multifunctionality Towards Immunotherapeutic Applications written by Kenth Gustafsson and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-02 with categories.
Signaling Mechanisms Regulating T Cell Diversity And Function
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Author : Jonathan Soboloff
language : en
Publisher: CRC Press
Release Date : 2017-03-27
Signaling Mechanisms Regulating T Cell Diversity And Function written by Jonathan Soboloff and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-27 with Medical categories.
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Recent Advances In T Cell Biology New Ligands New Functions And New Translational Perspectives
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Author : Dieter Kabelitz
language : en
Publisher: Frontiers Media SA
Release Date : 2016-02-16
Recent Advances In T Cell Biology New Ligands New Functions And New Translational Perspectives written by Dieter Kabelitz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-16 with Medicine (General) categories.
Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional α/β T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and >95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells. Dieter Kabelitz & Julie Déchanet-Merville
Gamma Delta T Cells
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Author : Shalini
language : en
Publisher: Tredition Gmbh
Release Date : 2024-05-13
Gamma Delta T Cells written by Shalini and has been published by Tredition Gmbh this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-13 with Medical categories.
Our bodies need protection against pathogen invasion and for that we employ our immune system which is armed with an arsenal of cells and proteins. This immune network is destined to eliminate microbes and substances determined to pose significant threat to the normal functioning of our bodies by confronting viruses, bacteria, toxins, fungi and parasites, or even by battling tumoral cells. So, the immune system develops mechanisms at least equal in effectiveness and ingenuity to the infectious or transforming threat. At the same time, the maintenance of homeostasis and prevention of self-destruction is a very important function managed also by the immune system via tolerance mechanisms. This orchestration and customisation of the immune system aim in securing our best survival1,2. The network of immune cells is usually divided into the innate and adaptive leg (figure I.1). The first harbours ready-for-action cells (e.g. monocytes, neutrophils, natural killer cells) and the second highly specialised agents (T and B lymphocytes). Even though separated in categories the cross talks and cooperation between the two legs are constant and crucial. T and B lymphocytes recognise and bind a broad range of antigens through the highly diverse antigen receptors on their surface (T-cell receptor for T lymphocytes and B-cell receptor for B lymphocytes) and confer the essential aspect of immunological memory1. In the T spectrum, there are unconventional cases of more rapid responders such as mucosal-associated invariant T (MAIT) cells (αβ), natural killer T (NKT) cells (αβ) or the γδ T cells3. The focus of this work is on the human γδ T cells and especially the Vγ9Vδ2 T cell population which provide unique functional specialisation.
Heat Shock Proteins And Gamma Delta T Cells
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Author : Celia F. Brosnan
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1992
Heat Shock Proteins And Gamma Delta T Cells written by Celia F. Brosnan and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
T Cells In Cancer
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Author : Ilan Bank
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-22
T Cells In Cancer written by Ilan Bank and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-22 with Medical categories.
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). Dr. Dieter Kabelitz currently serves as the chairman for the IUIS Education Committee. Topic Editor Prof. Ilan Bank is Chief Scientific Officer of GammaCell Bio-Technologies Ltd. Topic Editor Prof. Jurgen Kuball is co-founder and scientific advisor of GADETA. Topic Editor Prof. Bruno Silva-Santos is co-founder of Lymphact S.A., a company now owned by GammaDelta Therapeutics. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Clinical And Basic Immunodermatology
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Author : Anthony Gaspari
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-11-05
Clinical And Basic Immunodermatology written by Anthony Gaspari and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-05 with Medical categories.
Dermatologists are being asked to understand the pathophysiology of a number of immune-mediated skin diseases. In addition, a number of new products have appeared on the market during the past decade which requires an understanding of the mechanisms of action of these drugs. Dermatologists, however, have no easily understood book to which they can refer to regarding the disease or the drug.
T Cells In Physiology And Pathology
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Author : Xiaoli Wu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-12
T Cells In Physiology And Pathology written by Xiaoli Wu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-12 with Medical categories.
The Peripheral T Cell Lymphomas
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Author : Owen A. O'Connor
language : en
Publisher: John Wiley & Sons
Release Date : 2021-06-01
The Peripheral T Cell Lymphomas written by Owen A. O'Connor and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-01 with Medical categories.
THE PERIPHERAL T-CELL LYMPHOMAS Provides a comprehensive look at Peripheral T-Cell lymphomas, including the group’s unique geographic distribution, underlying genetics, and novel treatments Peripheral T-Cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represent 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat. For the first time in a single volume, The Peripheral T-Cell Lymphomas presents a comprehensive survey of this complex and rare group of blood cancers. Featuring contributions from an international team of leading authorities in the various aspects of PTCL, this authoritative text covers biology, epidemiology, classification, approved and emerging drugs, molecular genetics, and more. Detailed clinical chapters address diagnosis, prognosis, and treatment of each of the major PTCL subtypes identified in the 2018 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This much-needed resource: Covers the biological basis, epidemiology, classification, and treatment of PTCL Discusses the future of the field, including global collaboration efforts and novel approaches to PCTL Explores the role of biologics in PTCL and autologous and allogeneic stem-cell transplantation Offers new insights on molecular pathogenesis, innovative therapeutics, and novel drug combinations Features contributions from the Chairs The T-Cell Lymphoma Forum: the world’s largest meeting focused on PTCL Reflecting the unique epidemiology and genetic diversity of the PTCL, The Peripheral T-Cell Lymphomas is an indispensable source of data, insight, and references for the medical community, particularly oncologists and hematologists in both training and practice.