Gene Expression Systems In Fungi Advancements And Applications
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Gene Expression Systems In Fungi Advancements And Applications
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Author : Monika Schmoll
language : en
Publisher: Springer
Release Date : 2016-04-04
Gene Expression Systems In Fungi Advancements And Applications written by Monika Schmoll and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-04 with Science categories.
Biotechnology has emerged as one of the key environmentally safe technologies for the future which enables use of biomass to develop novel smart materials and to replace oil derived products. Fungi are the most efficient producers of the enzymes needed for this purpose and in addition they produce a plethora of secondary metabolites, among which novel antibiotics can be found. Industrial application and exploitation of the metabolic capacities of fungi requires highly productive and robust gene expression systems, which can be achieved by selection of appropriate species and strain improvement. In this book we aim to summarize homologous and heterologous gene expression systems of fungi for production of enzymes and secondary metabolites. A broad overview on requirements, challenges and successful applications shall serve as a basis for further development of fungi as biotechnological workhorses in research and industry.
Advances In Fungal Biotechnology For Industry Agriculture And Medicine
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Author : Jan S. Tkacz
language : en
Publisher: Springer Science & Business Media
Release Date : 2004
Advances In Fungal Biotechnology For Industry Agriculture And Medicine written by Jan S. Tkacz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
In the past half century, filamentous fungi have grown in commercial importance not only in the food industry but also as sources of pharmaceutical agents for the treatment of infectious and metabolic diseases and of specialty proteins and enzymes used to process foods, fortify detergents, and perform biotransformations. The commercial impact of molds is also measured on a negative scale since some of these organisms are significant as pathogens of crop plants, agents of food spoilage, and sources of toxic and carcinogenic compounds. Recent advances in the molecular genetics of filamentous fungi are finding increased application in the pharmaceutical, agricultural, and enzyme industries, and this trend promises to continue as the genomics of fungi is explored and new techniques to speed genetic manipulation become available. This volume focuses on the filamentous fungi and highlights the advances of the past decade, both in methodology and in the understanding of genomic organization and regulation of gene and pathway expression.
Genetic Transformation Systems In Fungi Volume 2
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Author : Marco A. van den Berg
language : en
Publisher: Springer
Release Date : 2014-10-31
Genetic Transformation Systems In Fungi Volume 2 written by Marco A. van den Berg and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-31 with Science categories.
Fungi are an economic very important class of microbes. Not only do they host a range of versatile enzymes used in industrial applications (biofuels, laundry, food processing), as well do they produce several very important pharmaceutical drugs (statins and penicillins). Moreover, fungal pathogens can cause great damage in agricultural production (Phytophthora and Botrytis) and during mammalian infections (Penicillium marneffei and Candida). Transformation of DNA is used to understand the genetic basis behind these traits. Several different techniques have been developed over the years and readily shown to be decisive methods to improve fungal biotechnology. This book will cover the basics behind the most commonly used transformation methods, as well as associated tools and techniques. Each chapter will provide protocols along with examples to be used in laboratories worldwide.
Genetics And Biotechnology
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Author : J. Philipp Benz
language : en
Publisher: Springer Nature
Release Date : 2020-10-28
Genetics And Biotechnology written by J. Philipp Benz and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-28 with Science categories.
This fully revised third edition includes up-to-date topics and developments in the field, which has made tremendous strides since the publication of the second edition in 2004. Many novel techniques based on Next Generation Sequencing have sped up the analysis of fungi and major advances have been made in genome editing, leading to a deeper understanding of the genetics underlying cellular processes as well as their applicability. At the same time, the relevance of fungi is unbroken, both due to the serious threats to human health and welfare posed by fungal pests and pathogens, and to the many benefits that fungal biotechnology can offer for diverse emerging markets and processes that form the basis of the modern bioeconomy. With regard to these advances, the first section of this volume, Genetics, illustrates the basic genetic processes underlying inheritance, cell biology, metabolism and “lifestyles” of fungi. The second section, Biotechnology, addresses the applied side of fungal genetics, ranging from new tools for synthetic biology to the biotechnological potential of fungi from diverse environments. Gathering chapters written by reputed scientists, the book represents an invaluable reference guide for fungal biologists, geneticists and biotechnologists alike.
Laboratory Protocols In Fungal Biology
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Author : Vijai Kumar Gupta
language : en
Publisher: Springer
Release Date : 2016-08-23
Laboratory Protocols In Fungal Biology written by Vijai Kumar Gupta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Science categories.
Laboratory Protocols in Fungal Biology presents the latest techniques in fungal biology. This book analyzes information derived through real experiments, and focuses on cutting edge techniques in the field. The book comprises 57 chapters contributed from internationally recognised scientists and researchers. Experts in the field have provided up-to-date protocols covering a range of frequently used methods in fungal biology. Almost all important methods available in the area of fungal biology viz. taxonomic keys in fungi; histopathological and microscopy techniques; proteomics methods; genomics methods; industrial applications and related techniques; and bioinformatics tools in fungi are covered and complied in one book. Chapters include introductions to their respective topics, list of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting. Each chapter is self-contained and written in a style that enables the reader to progress from elementary concepts to advanced research techniques. Laboratory Protocols in Fungal Biology is a valuable tool for both beginner research workers and experienced professionals. Coming Soon in the Fungal Biology series: Goyal, Manoharachary / Future Challenges in Crop Protection Against Fungal Pathogens Martín, García-Estrada, Zeilinger / Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites Zeilinger, Martín, García-Estrada / Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2 van den Berg, Maruthachalam / Genetic Transformation Systems in Fungi Schmoll, Dattenbock / Gene Expression Systems in Fungi Dahms / Advanced Microscopy in Mycology
Development And Application Of Novel Genome Engineering Tools In Microbial Biotechnology
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Author : Jiazhang Lian
language : en
Publisher: Frontiers Media SA
Release Date : 2021-01-20
Development And Application Of Novel Genome Engineering Tools In Microbial Biotechnology written by Jiazhang Lian and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-20 with Science categories.
Advances In The Regulation And Production Of Fungal Enzymes By Transcriptomics Proteomics And Recombinant Strains Design
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Author : André Damasio
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-04
Advances In The Regulation And Production Of Fungal Enzymes By Transcriptomics Proteomics And Recombinant Strains Design written by André Damasio and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-04 with categories.
Several efforts have been made in developing strategies to supply the enzyme market, as well as in reducing its costs. It includes the selection of an appropriate enzyme source and the optimization of enzyme properties and secretion. Carbohydrate-Active Enzymes (CAZymes) are industrially relevant biocatalysts that are capable of degrading plant cell wall biomass. The most important secreted enzymes related to plant cell wall decomposition are cellulases, hemicellulases, and auxiliary enzymes. These enzymes have been applied in the hydrolysis of plant biomass for the production of second-generation (2G) ethanol and several other high added value products. One of the bottlenecks for 2G ethanol production is the cost of enzymes applied on plant biomass hydrolysis. The improvement of proteins production by fungi applying system biology and genetic engineering is an interesting and promising strategy to reduce the enzymes cost and make the 2G ethanol production viable. Fungi play an important role in plant biomass degradation and biotechnology by producing and secreting high yields of enzymes. In spite of the fact that filamentous fungi present several advantages compared to other microorganisms due to the high level of proteins production, heterologous protein production is far from optimal levels and still needs to be improved. Currently, heterologous production of certain proteins is generally considerably lower than the levels obtained to homologous production. Many strategies have been studied in order to improve heterologous production of proteins by filamentous fungi, including the deletion of genes that encode for proteases, the deletion of lectin-like ER-Golgi cargo receptors and the co-expression of specific chaperones. It has been shown that the main bottleneck in the production of heterologous proteins is not caused by the low expression of the target gene. An experimental evidence suggests that most target proteins produced in filamentous fungi are lost or stuck in the secretory pathway due to errors in processing, modification or misfolding that result in their elimination by endoplasmic reticulum (ER) quality control. Misfolded proteins alter homeostasis and proper ER functioning resulting in a state known as ER stress. ER stress activates a conserved signaling pathway called unfolded protein response (UPR) and ER-associated protein degradation (ERAD), which upregulates genes responsible for restoring protein folding homeostasis in the cell and degrades misfolded protein in the cytosol by the ubiquitin-proteasome system. The genetic manipulation of individual genes and changes in the genome seems not to be the best alternative to overcome the main bottlenecks in heterologous protein secretion. However, the understanding of complex interactions of important proteins and genes, as well as how they are regulated is more promising.
Advances In Trichoderma Biology For Agricultural Applications
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Author : N. Amaresan
language : en
Publisher: Springer Nature
Release Date : 2022-06-09
Advances In Trichoderma Biology For Agricultural Applications written by N. Amaresan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-09 with Science categories.
Advances in Trichoderma Biology for Agricultural Applications covers the beneficial properties of Trichoderma in enhancing global agricultural productivity. Trichoderma are biotechnologically significant fungi, being widely used both agriculturally and industrially. In many cases Trichoderma are also a potential drug source of clinical importance. In recent years, driven by advances in genetics and genomics, research on these fungi has opened new avenues for its various applications. This book covers i) Current state of Trichoderma taxonomy, and species identification, ii) Trichoderma and plant-pathogenic fungi interactions, iii) Trichoderma interactions with plants, including rhizosphere competence of Trichoderma, antagonistic potentials, plant growth promotion, and management of various abiotic stresses in plants, iv) Practical aspects of Trichoderma commercialization in agriculture, v) Biosynthesis of metal-based nanoparticles and its application, and vi) Negative impact of Trichoderma strains in the environments. Reading this book should kindle further discussions among researchers working in fungal biotechnology, microbiology, agriculture, environmental science, forestry, and other allied subjects and thus lead to a broader scope of Trichoderma-based products and technologies. The knowledge shared in this book should also provide a warning on the potential risks associated with Trichoderma.
Fungal Biotechnology And Bioengineering
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Author : Abd El-Latif Hesham
language : en
Publisher: Springer Nature
Release Date : 2020-06-18
Fungal Biotechnology And Bioengineering written by Abd El-Latif Hesham and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-18 with Science categories.
Fungi are eukaryotic microorganisms that include both unicellular and multicellular species. They have a worldwide distribution and a wide range of applications in diverse sectors, from environmental, food and medicine to biotechnological innovations. Fungal biochemical genetics involves the study of the relationships between genome, proteome and metabolome, and the underlying molecular processes in both native and bioengineered fungi. This book provides a valuable resource on the challenges and potential of fungal biotechnology and related bioengineering and functional diversity for various industrial applications in the food, environmental, bioenergy and biorefining, and the biopharma sectors. In comparison to previous and related publications in the area of applied myco-biotech-engineering, this book bridges a knowledge gap in the areas related to prospects and investment as well as intellectual and technical issues. This book also provides information on recent commercial and economic interests in the area by juxtaposing the developments achieved in recent worldwide research and its many challenges.
Fungal Cellulolytic Enzymes
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Author : Xu Fang
language : en
Publisher: Springer
Release Date : 2018-08-31
Fungal Cellulolytic Enzymes written by Xu Fang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-31 with Medical categories.
The book provides an overview of the current knowledge on cellulolytic enzymes and their applications. It summarizes the mechanisms of synthesis and hydrolysis of cellulolytic enzymes, industrial fungal strains, genetic engineering of fungal strains and application of cellulolytic enzymes. This book will be a useful reference for researchers and bioengineering experts engaged in lignocelluloses biodegradation, biomass utilization, enzyme production and fungal molecular biology.