Gene Profiling In Breast Cancer

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Impact Of Gene Expression Profiling Tests On Breast Cancer Outcomes

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Author : Luigi Marchionni
language : en
Publisher: DIANE Publishing
Release Date : 2009-05

Impact Of Gene Expression Profiling Tests On Breast Cancer Outcomes written by Luigi Marchionni and has been published by DIANE Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05 with Medical categories.

Assesses the evidence that three marketed gene expression-based assays improve prognostic accuracy, treatment choice, and health outcomes in women diagnosed with early stage breast cancer. Three gene expression assays were evaluated; Oncotype DX¿, MammaPrint® and the Breast Cancer Profiling (BCP or H/I ratio) test, and for gene expression signatures underlying the assays. They sought evidence on: analytic performance of tests; clinical validity; clinical utility; harms; and impact on clinical decision making and health care costs. Conclusions: Oncotype DX is furthest along the validation pathway, with retrospective evidence that it predicts distant spread and chemotherapy benefit to a clinically relevant extent over standard predictors. Illus.

Impact Of Gene Expression Profiling Tests On Breast Cancer Outcomes

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Author : Luigi Marchionni (M.D.)
language : en
Publisher:
Release Date : 2008-01-01

Impact Of Gene Expression Profiling Tests On Breast Cancer Outcomes written by Luigi Marchionni (M.D.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-01 with Breast categories.

Gene Expression Profiling In Breast Cancer

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Author : Juliane Hannemann
language : en
Publisher:
Release Date : 2007

Gene Expression Profiling In Breast Cancer written by Juliane Hannemann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.

A Comparison Of Gene Expression Profiling Tests For Breast Cancer

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Author : Pam Smartt
language : en
Publisher:
Release Date : 2010

A Comparison Of Gene Expression Profiling Tests For Breast Cancer written by Pam Smartt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Breast categories.

Gene Profiling In Breast Cancer

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Author :
language : en
Publisher:
Release Date : 2009

Gene Profiling In Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.

Hypothesis Driven Gene Expression Profiling In Breast Cancer

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Author : Dimitry Serge Antoine Nuyten
language : en
Publisher:
Release Date : 2010

Hypothesis Driven Gene Expression Profiling In Breast Cancer written by Dimitry Serge Antoine Nuyten and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.

Constructive Technology Assessment Of Gene Expression Profiling For Breast Cancer

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Author : Valesca Pavlawna Retèl
language : en
Publisher:
Release Date : 2011

Constructive Technology Assessment Of Gene Expression Profiling For Breast Cancer written by Valesca Pavlawna Retèl and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.

Gene Expression Profiling Of Breast Cancer To Identify Subtypes And To Predict Local Recurrence After Breast Conserving Therapy

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Author : Bas Kreike
language : en
Publisher:
Release Date : 2011

Gene Expression Profiling Of Breast Cancer To Identify Subtypes And To Predict Local Recurrence After Breast Conserving Therapy written by Bas Kreike and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.

The Application Of Gene Expression Profiling To Clinical Breast Cancer Research

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Author : Sherene Loi
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2009

The Application Of Gene Expression Profiling To Clinical Breast Cancer Research written by Sherene Loi and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.

The book has three main results parts. Chapter 3 illustrates the first independent validation study of a 70-gene signature developed from gene expression profiling for use in breast cancer prognosis and demonstration of its ability to add independent prognostic information to the clinical prognostic factors currently used. The successful validation of this study preceded the design and implementation of a world-wide randomized clinical trial evaluating the gene signature's clinical utility. This trial has commenced and is currently recruiting in Europe. Chapter 4 describes the finding that proliferation-related genes can predict clinical outcome consistently in breast cancer and many gene signatures developed for predicting breast cancer prognosis derive a significant proportion of their prognostic power from these genes. Finally, chapter 5 describes the use of proliferation-related genes to define two distinct prognostic molecular subgroups within estrogen receptor positive breast cancers.

Gene Profiling Of Protease Induced Genes In Breast Cancer

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Author : Wolfram Ruf
language : en
Publisher:
Release Date : 2001

Gene Profiling Of Protease Induced Genes In Breast Cancer written by Wolfram Ruf and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.

The thrombin receptor (protease activated receptor 1, PAR-i) is not detectable in non-invasive ductal carcinoma in situ, but is highly upregulated in invasive breast cancer. In breast cancer cell lines, PAR-i is expressed in more metastatic cells, conferring sensitivity to thrombin. Gene profiling of breast cancer cells stimulated with thrombin or a direct PAR-i agonist demonstrate the upregulation of genes that support cell survival and that regulate angiogenesis. Large scale gene profiling for expression tagged genes (ests) indicate additional downstream gene targets of thrombin signaling. These genes may prove of relevance for breast cancer progression.