Gene Therapy For Acute And Acquired Diseases
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Gene Therapy For Acute And Acquired Diseases
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Author : Phillip H. Factor
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Gene Therapy For Acute And Acquired Diseases written by Phillip H. Factor and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In recent years much enthusiasm and energy has been directed toward the development of human gene therapies, especially for inherited conditions and cancers. However, current gene transfer technology is limited in its transduction efficiency and ability to permanently and safely correct genomic defects. Thus the promise of gene therapy for these conditions is as yet unrealized. The progression of gene transfer technology will eventually surmount these limitations. Gene Therapy for Acute and Acquired Diseases includes selected examples of ongoing studies in molecular genetics that have the potential to evolve into human therapies for acute illnesses. These chapters are intended to highlight lesser known applications of gene therapy for acquired disorders. It is expected that human gene therapy trials for these conditions will be forthcoming in the near future, leading to previously unimaginable therapies. Thus, this first-ever book about gene therapy for acute and acquired diseases is intended to serve as a glimpse into the future.
Gene Therapy
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Author : Joseph Panno
language : en
Publisher: Infobase Publishing
Release Date : 2005
Gene Therapy written by Joseph Panno and has been published by Infobase Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Biology categories.
Many diseases are caused by a simple point mutation.
Immunopharmacology
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Author : Manzoor M. Khan
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-19
Immunopharmacology written by Manzoor M. Khan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-19 with Medical categories.
During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
Gene Therapy Protocols
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Author : Paul D. Robbins
language : en
Publisher: Humana Press
Release Date : 1996-10-01
Gene Therapy Protocols written by Paul D. Robbins and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-10-01 with Medical categories.
In the last few years, significant advances have been made in the area of gene therapy for both genetic and acquired diseases. Improvement in gene transfer methods has allowed for development of gene therapy protocols for the treatment of diverse types of diseases, including metabolic, cardiovas- lar, and autoimmune diseases, as well as cancer. For example, clinical trials for gene therapy of cancer, cystic fibrosis, ADA deficiency, and arthritis, among others, have been initiated in recent years. It is likely that, in the near future, gene therapy will become a common form of treatment for many different types of diseases. Gene therapy takes advantage of recent advances in many areas of molecular and cell biology, including the identification of new the- peutic genes, improvement in both viral and nonviral gene delivery systems, better understanding of gene regulation, and improvement in cell isolation and transplantation. Because of the different and complex techniques involved in achieving successful gene-mediated therapies, it is difficult for scientists to perform all methods required for gene delivery and subsequent in vivo gene expression. This Gene Therapy Protocols volume in the Methods in Molecular Me- cine series provides scientists with detailed methods for working with gene transfer systems, and methods for gene transfer to specific tissue types either in vivo or ex vivo.
Polymers And Nanomaterials For Gene Therapy
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Author : Ravin Narain
language : en
Publisher: Woodhead Publishing
Release Date : 2016-01-09
Polymers And Nanomaterials For Gene Therapy written by Ravin Narain and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-09 with Science categories.
Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications
Acute Respiratory Distress Syndrome
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Author : Sadis Matalon
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Acute Respiratory Distress Syndrome written by Sadis Matalon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Proceedings of a NATO ASI held in Corfu, Greece, June 15-25, 1997
Pharmaceutical Biotechnology
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Author : Daan J. A. Crommelin
language : en
Publisher: CRC Press
Release Date : 2002-11-14
Pharmaceutical Biotechnology written by Daan J. A. Crommelin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-11-14 with Medical categories.
The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.
Gene Therapy For Diseases Of The Lung
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Author : Kenneth Brigham
language : en
Publisher: CRC Press
Release Date : 2020-10-14
Gene Therapy For Diseases Of The Lung written by Kenneth Brigham and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-14 with Medical categories.
This up-to-the-minute and comprehensive resource lucidly covers gene therapy for lung diseases from existing technologies delivering foreign DNA to the lungs via the airways or circulation to promising new approaches for the further development of safe and efficient gene delivery systems.
Gene Therapy For Viral Infections
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Author : Patrick Arbuthnot
language : en
Publisher: Academic Press
Release Date : 2015-06-01
Gene Therapy For Viral Infections written by Patrick Arbuthnot and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-01 with Science categories.
Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field
Encyclopedia Of Genetics Genomics Proteomics And Informatics
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Author : George P. Rédei
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-04-25
Encyclopedia Of Genetics Genomics Proteomics And Informatics written by George P. Rédei and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-25 with Medical categories.
This new third edition updates a best-selling encyclopedia. It includes about 56% more words than the 1,392-page second edition of 2003. The number of illustrations increased to almost 2,000 and their quality has improved by design and four colors. It includes approximately 1,800 current databases and web servers. This encyclopedia covers the basics and the latest in genomics, proteomics, genetic engineering, small RNAs, transcription factories, chromosome territories, stem cells, genetic networks, epigenetics, prions, hereditary diseases, and patents. Similar integrated information is not available in textbooks or on the Internet.