Generation Of Recombinant Capripoxvirus Vaccines
DOWNLOAD
Download Generation Of Recombinant Capripoxvirus Vaccines PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Generation Of Recombinant Capripoxvirus Vaccines book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Generation Of Recombinant Capripoxvirus Vaccines
DOWNLOAD
Author : Mahder Teffera
language : en
Publisher:
Release Date : 2020
Generation Of Recombinant Capripoxvirus Vaccines written by Mahder Teffera and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Capripoxvirus (CAPV) represents a genus of the poxviridae family which includes: sheep pox virus (SPPV), goat pox virus (GTPV), and lumpy skin disease virus (LSDV) affecting sheep, goats, and cattle respectively. Peste des petits ruminants (PPR) is a viral disease of ruminants caused by the morbillivirus, peste des petits ruminants virus (PPRV). These World Organization of Animal Health notifiable diseases continue to infect animals causing morbidity and mortality leading to direct and indirect economic losses in endemic countries. Currently, vaccination using live attenuated vaccines is used to control these diseases. Due to the concurrent prevalence of CAPV and PPR, the use of a bivalent vaccine would be a cost effective approach to control the diseases in sheep and goats. A live attenuated CAPV vaccine was genetically modified to express an antigenic protein from PPR. This was done using the Romanian CAPV vaccine and inserting the hemagglutinin (H) protein of PPR (Moroccan) in the IL-10 homologue gene region. This project offers a solution for the eradication of PPR as provides a thermostable vaccine which can be used instead of live attenuated PPR vaccines which are thermos-labile. Additionally, it provides a cost effective method to control CAPV diseases and PPR. The second project deals with differentiating infected from vaccinated animal vaccines (DIVA). Due to the complete immune response generated by immunized animals to conventional vaccines, it is not possible to use existing serological tests to identify whether an animal has been vaccinated or infected. Two live attenuated CAPV vaccines were utilized to generate these vaccines by attempting to knock out what was believed to be a non-essential gene. These attempts to knock out the CP25 gene of both LSDV and SPPV were not successful. It was determined that the CP25 protein is likely essential for virus replication. This project is important since it would provide an improved solution to respond to CAPV outbreaks in endemic and non-endemic countries. The current spread of LSDV throughout Europe and previous reported outbreaks of SPPV, GTPV, and LSDV in many countries highlights the need for a DIVA vaccine to improve the control of CAPV diseases.
Emerging Arboviruses
DOWNLOAD
Author : William C. Wilson
language : en
Publisher: Frontiers Media SA
Release Date : 2021-01-25
Emerging Arboviruses written by William C. Wilson and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-25 with Medical categories.
Veterinary Vaccines
DOWNLOAD
Author : Samia Metwally
language : en
Publisher: John Wiley & Sons
Release Date : 2021-04-01
Veterinary Vaccines written by Samia Metwally and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-01 with Medical categories.
Provides a concise and authoritative reference on the use of vaccines against diseases of livestock Compiled by Senior Animal Health Officers at The Food and Agriculture Organization of the United Nations, and with contributions from international leading experts, Veterinary Vaccines: Principles and Applications is a concise and authoritative reference featuring easily readable reviews of the latest research in vaccinology and vaccine immune response to pathogens of major economic impact to livestock. It covers advice and recommendations for vaccine production, quality control, and effective vaccination schemes including vaccine selection, specifications, vaccination programs, vaccine handling in the field, application, failures, and assessment of herd protection. In addition, the book presents discussions on the current status and potential future developments of vaccines and vaccination against selected transboundary animal diseases. Provides a clear and comprehensive guide on using veterinary vaccines to protect livestock from diseases Teaches the principles of vaccinology and vaccine immune response Highlights the vaccine production schemes and standards for quality control testing Offers easy-to-read reviews of the most current research on the subject Gives readers advice and recommendations on which vaccination schemes are most effective Discusses the today’s state of vaccines and vaccination against selected transboundary animal diseases as well as possible future developments in the field Veterinary Vaccines: Principles and Applications is an important resource for veterinary practitioners, animal health department officials, vaccine scientists, and veterinary students. It will also be of interest to professional associations and NGO active in livestock industry.
Lumpy Skin Disease
DOWNLOAD
Author : Eeva S. M. Tuppurainen
language : en
Publisher: Springer
Release Date : 2018-07-03
Lumpy Skin Disease written by Eeva S. M. Tuppurainen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-03 with Medical categories.
This book provides a comprehensive but concise overview on the economically important emerging cattle pox virus derived Lumpy Skin Disease, including the characteristics of causative agent, description of clinical signs in cattle, pathology and histopathology, immunity, geographical distribution, epidemiology and transmission pathways, control and eradication of the disease. In addition the recent developments in vaccination, mathematical modeling and risk assessment are discussed. Lumpy Skin Disease currently spreads aggressively across the Middle and Near East. The first incursion to the European Union territory occurred in Greece in autumn 2015. The book targets clinicians and field veterinarians in Lumpy Skin Disease affected regions, veterinary authorities as well as advanced students in veterinary medicine and virology.
Viral Vectors In Veterinary Vaccine Development
DOWNLOAD
Author : Thiru Vanniasinkam
language : en
Publisher: Springer Nature
Release Date : 2020-11-30
Viral Vectors In Veterinary Vaccine Development written by Thiru Vanniasinkam and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-30 with Medical categories.
This highly accessible textbook introduces readers to the development of viral vectors and discusses their application in veterinary vaccinology. It offers comprehensive information on the latest advances in this emerging research field, together with a broad overview of the history of veterinary vaccines and viral vectors. The book also addresses issues concerning funding, translational research and ethics that will impact the future development, manufacture and global use of viral vector-based veterinary vaccines. The book addresses the needs of graduate students and researchers in the fields of Veterinary Medicine, Virology and Immunology.
Infectious Diseases Of Livestock
DOWNLOAD
Author : J. A. W. Coetzer
language : en
Publisher: Oxford University Press, USA
Release Date : 2004
Infectious Diseases Of Livestock written by J. A. W. Coetzer and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Africa, Southern categories.
Previous ed.: Infectious diseases of livestock with special reference to Southern Africa, 1994.
Recombinant Poxviruses
DOWNLOAD
Author : Matthew M. Binns
language : en
Publisher: CRC Press
Release Date : 1992-05-27
Recombinant Poxviruses written by Matthew M. Binns and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-05-27 with Science categories.
Recombinant Poxviruses provides a comprehensive examination of poxviruses with an emphasis on the potential of these viruses as new vaccines. The book considers a wide range of issues involved in producing new genetically engineered live vaccines, such as efficacy, safety, stability, cost, host range, immune response, immunization route, use of multivalent vaccines, and need for revaccination. The opening chapter describes the origin of vaccinia virus, its use to eradicate smallpox, and the pathogenesis of poxvirus infections. Subsequent chapters examine the molecular biology of poxviruses, methods of constructing vaccinia virus recombinants, and applications; the use and immune responses induced by poxvirus recombinants as live vaccines; and the important issues of the safety and immunogenicity of vaccinia virus. The book's final two chapters report the progress that has been made developing avipoxviruses and parapoxviruses as candidate recombinant vaccines. Recombinant Poxviruses will be a welcome addition to the bookshelves of virologists, microbiologists, infectious disease specialists, and veterinarians.
Animal Origin Viral Zoonoses
DOWNLOAD
Author : Yashpal Singh Malik
language : en
Publisher: Springer Nature
Release Date : 2020-09-23
Animal Origin Viral Zoonoses written by Yashpal Singh Malik and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-23 with Medical categories.
This book is the second volume in the series Livestock Diseases and Management, and reviews the importance and implications of animal origin viral zoonoses. It also highlights the specific etiology and epidemiology of these viral infections and discusses their various biological and mechanical transmission mechanisms. Further, the book reviews various measures for controlling viral zoonoses and examines novel therapeutic and prophylactic strategies. Discussing recent studies on the pathogenesis and host immune response to these infections, it underscores the importance of using vaccines against these viral diseases to reduce the risk of them being transmitted to humans.Lastly, it describes in detail the challenges posed by these viral infections and our readiness to face them.
Poxviruses
DOWNLOAD
Author : Richard W. Moyer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Poxviruses written by Richard W. Moyer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The purpose of this volume is to highlight some current areas of poxvirus research which are likely to be particularly fruitful in the upcoming few years. The first chapter, by Drs. Condit and Niles, discusses poxvirus genetics. Work in this area has provided mutants, produced practical procedures to simplify the manipulation of viral genes, and generated information about the molecular architecture and organization of genes characteristic of pox viruses. One of the most intensively studied regions of the viral genome is the HindIII D region of vaccinia, in which a combination of classical and molecular genetic analysis of the region has been particularly revealing. Within this region are open reading frames, some of which are expressed early and others late, organized in a fashion which is now known to be typical of these viruses. Other studies, related to temperature sensitive, drug resistant, and drug dependent mutants, are also discussed. Each of the other reviews included in this volume summarizes areas of research which have depended heavily on the genetics of the system. The intracellular site of a poxvirus infection is mostly, if not exclusively, limited to the cytoplasm which dictates several interesting biological ramifications. For example, poxvirus transcription must occur in the cytoplasm, rather than in the nucleus. The virus copes with this situation by incorporating into the virion the enzymatic machinery necessary to initiate transcription from input virus.
Cumulated Index Medicus
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 1999
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medicine categories.