Recombinant Poxviruses
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Recombinant Poxviruses
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Author : Matthew M. Binns
language : en
Publisher: CRC Press
Release Date : 1992-05-27
Recombinant Poxviruses written by Matthew M. Binns and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-05-27 with Science categories.
Recombinant Poxviruses provides a comprehensive examination of poxviruses with an emphasis on the potential of these viruses as new vaccines. The book considers a wide range of issues involved in producing new genetically engineered live vaccines, such as efficacy, safety, stability, cost, host range, immune response, immunization route, use of multivalent vaccines, and need for revaccination. The opening chapter describes the origin of vaccinia virus, its use to eradicate smallpox, and the pathogenesis of poxvirus infections. Subsequent chapters examine the molecular biology of poxviruses, methods of constructing vaccinia virus recombinants, and applications; the use and immune responses induced by poxvirus recombinants as live vaccines; and the important issues of the safety and immunogenicity of vaccinia virus. The book's final two chapters report the progress that has been made developing avipoxviruses and parapoxviruses as candidate recombinant vaccines. Recombinant Poxviruses will be a welcome addition to the bookshelves of virologists, microbiologists, infectious disease specialists, and veterinarians.
Vaccinia Virus And Poxvirology
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Author : Stuart N. Isaacs
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Vaccinia Virus And Poxvirology written by Stuart N. Isaacs and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Science categories.
The Right Book at the Right Time The poxviruses comprise a family of complex DNA viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. Of the eight recognized g- era of vertebrate poxviruses, those belonging to the orthopoxvirus genus have been most intensively studied. This group includes variola virus, the agent of smallpox, as well as cowpox virus and vaccinia virus. Jenner’s original sma- pox vaccine, described in 1798, consisted of live cowpox virus, but vaccinia virus later replaced it (1). There has been speculation as to the origin of v- cinia virus; the most likely idea is that it is a separate species, possibly ori- nally isolated from a horse, and is now extinct or rare in nature (2). Recent genome sequencing studies confirm the distinctness of variola virus, cowpox virus, and vaccinia virus and also their very close genetic relationship, which accounts for the cross protection of smallpox vaccines. The novelty of the smallpox vaccine can be readily appreciated by the time it took, about 80 years, before the next live vaccine against rabies was developed, and another 50 years for the yellow fever vaccine. Moreover, the eradication of smallpox in 1977 stands as a unique medical achievement. Because of its historical role, sma- pox vaccination contributed greatly to present concepts of infectious disease, immunity, and pathogenesis. Less well known, however, are the many other “firsts” for vaccinia virus.
Poxviruses
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Author : Richard W. Moyer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Poxviruses written by Richard W. Moyer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The purpose of this volume is to highlight some current areas of poxvirus research which are likely to be particularly fruitful in the upcoming few years. The first chapter, by Drs. Condit and Niles, discusses poxvirus genetics. Work in this area has provided mutants, produced practical procedures to simplify the manipulation of viral genes, and generated information about the molecular architecture and organization of genes characteristic of pox viruses. One of the most intensively studied regions of the viral genome is the HindIII D region of vaccinia, in which a combination of classical and molecular genetic analysis of the region has been particularly revealing. Within this region are open reading frames, some of which are expressed early and others late, organized in a fashion which is now known to be typical of these viruses. Other studies, related to temperature sensitive, drug resistant, and drug dependent mutants, are also discussed. Each of the other reviews included in this volume summarizes areas of research which have depended heavily on the genetics of the system. The intracellular site of a poxvirus infection is mostly, if not exclusively, limited to the cytoplasm which dictates several interesting biological ramifications. For example, poxvirus transcription must occur in the cytoplasm, rather than in the nucleus. The virus copes with this situation by incorporating into the virion the enzymatic machinery necessary to initiate transcription from input virus.
Developing Recombinant Poxvirus Vaccines
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Author : Rikke Fredslund Andersen
language : en
Publisher:
Release Date : 2005
Developing Recombinant Poxvirus Vaccines written by Rikke Fredslund Andersen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Poxvirus diseases categories.
Selectable Markers For Recombinant Poxviruses
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Author : Elizabeth Gertruida Brand
language : en
Publisher:
Release Date : 1993
Selectable Markers For Recombinant Poxviruses written by Elizabeth Gertruida Brand and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.
Recombinant Raccoon Poxvirus Vectored Feline Vaccines
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Author : Christopher Kulova Ngichabe
language : en
Publisher:
Release Date : 1992
Recombinant Raccoon Poxvirus Vectored Feline Vaccines written by Christopher Kulova Ngichabe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Selected Markers For Recombinant Poxvirus
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Author : Elizabeth Gertruida Brand
language : en
Publisher:
Release Date : 1993*
Selected Markers For Recombinant Poxvirus written by Elizabeth Gertruida Brand and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993* with Genetic vectors categories.
The Orthopoxviruses
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Author : Frank Fenner
language : en
Publisher: Elsevier
Release Date : 2012-12-02
The Orthopoxviruses written by Frank Fenner and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
The Orthopoxviruses presents knowledge and comprehensive and integrated picture of orthopoxviruses. The book looks into the molecular biology of this genusof viruses, particularly, the structure and chemical composition of the virion, replication, morphogenesis, pathogenesis, pathology, and immunology of this virus’ infections. It also elucidates the global spread, control, and eradication of smallpox. Additionally, the book describes a potentially important use of vaccinia virus, namely, its use as a vector for genes from other viruses, bacteria, or protozoa that specify antigens important in stimulating the production of a protective immune response. Such comprehensive account of all aspects of the biology of all known species of orthopoxviruses will be valuable to molecular biologists, virologists, immunologists, pathologists, and researchers in the veterinary sciences.
Molecular Characterization Of A Recombinant Poxvirus
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Author : Elchonon Michael Berkowitz
language : en
Publisher:
Release Date : 1986
Molecular Characterization Of A Recombinant Poxvirus written by Elchonon Michael Berkowitz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with categories.
Biology Of Poxviruses
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Author : Samuel Dales
language : en
Publisher: Springer
Release Date : 1981
Biology Of Poxviruses written by Samuel Dales and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Poxviridae categories.
Publisher description -- This program examines the way metals can be manipulated when making products. It covers the operations in each of the three most common methods of forming used in manufacturing: heating, cold forming and milling.