Developing Recombinant Poxvirus Vaccines
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Developing Recombinant Poxvirus Vaccines
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Author : Rikke Fredslund Andersen
language : en
Publisher:
Release Date : 2005
Developing Recombinant Poxvirus Vaccines written by Rikke Fredslund Andersen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Poxvirus diseases categories.
Recombinant Poxviruses
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Author : Matthew M. Binns
language : en
Publisher: CRC Press
Release Date : 1992-05-27
Recombinant Poxviruses written by Matthew M. Binns and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-05-27 with Science categories.
Recombinant Poxviruses provides a comprehensive examination of poxviruses with an emphasis on the potential of these viruses as new vaccines. The book considers a wide range of issues involved in producing new genetically engineered live vaccines, such as efficacy, safety, stability, cost, host range, immune response, immunization route, use of multivalent vaccines, and need for revaccination. The opening chapter describes the origin of vaccinia virus, its use to eradicate smallpox, and the pathogenesis of poxvirus infections. Subsequent chapters examine the molecular biology of poxviruses, methods of constructing vaccinia virus recombinants, and applications; the use and immune responses induced by poxvirus recombinants as live vaccines; and the important issues of the safety and immunogenicity of vaccinia virus. The book's final two chapters report the progress that has been made developing avipoxviruses and parapoxviruses as candidate recombinant vaccines. Recombinant Poxviruses will be a welcome addition to the bookshelves of virologists, microbiologists, infectious disease specialists, and veterinarians.
Vaccinia Virus And Poxvirology
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Author : Stuart N. Isaacs
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Vaccinia Virus And Poxvirology written by Stuart N. Isaacs and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Science categories.
The Right Book at the Right Time The poxviruses comprise a family of complex DNA viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. Of the eight recognized g- era of vertebrate poxviruses, those belonging to the orthopoxvirus genus have been most intensively studied. This group includes variola virus, the agent of smallpox, as well as cowpox virus and vaccinia virus. Jenner’s original sma- pox vaccine, described in 1798, consisted of live cowpox virus, but vaccinia virus later replaced it (1). There has been speculation as to the origin of v- cinia virus; the most likely idea is that it is a separate species, possibly ori- nally isolated from a horse, and is now extinct or rare in nature (2). Recent genome sequencing studies confirm the distinctness of variola virus, cowpox virus, and vaccinia virus and also their very close genetic relationship, which accounts for the cross protection of smallpox vaccines. The novelty of the smallpox vaccine can be readily appreciated by the time it took, about 80 years, before the next live vaccine against rabies was developed, and another 50 years for the yellow fever vaccine. Moreover, the eradication of smallpox in 1977 stands as a unique medical achievement. Because of its historical role, sma- pox vaccination contributed greatly to present concepts of infectious disease, immunity, and pathogenesis. Less well known, however, are the many other “firsts” for vaccinia virus.
Development Of Raccoon Poxvirus Vectored Feline Recombinant Vaccines
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Author : Liangbiao Hu
language : en
Publisher:
Release Date : 1995
Development Of Raccoon Poxvirus Vectored Feline Recombinant Vaccines written by Liangbiao Hu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Introduction To Recombinant Vaccines
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Author : Dr. Ramesh C.K.
language : en
Publisher: Lulu.com
Release Date :
Introduction To Recombinant Vaccines written by Dr. Ramesh C.K. and has been published by Lulu.com this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Poxviruses
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Author : Andrew Mercer
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-02-15
Poxviruses written by Andrew Mercer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-15 with Medical categories.
This monograph provides a comprehensive review of the poxvirus family with a particular emphasis on current developments. It includes the latest insights into poxviral molecular biology, diagnosis, therapy, vaccine development and the beneficial exploitation of these viruses in biomedical research. Each chapter is written by a leader in the field, and the book includes historical perspectives and summaries of recent advances in the field.
Recombinant Vectors In Vaccine Development
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Author : Fred Brown
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1994
Recombinant Vectors In Vaccine Development written by Fred Brown and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
This volume explores the use of recombinant vectors in the development of new vaccines to benefit both human and animal health. Emphasis is placed on bacterial and viral vectors and their applications.
Recombinant Virus Vaccines
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Author : Maureen C. Ferran
language : en
Publisher:
Release Date : 2017
Recombinant Virus Vaccines written by Maureen C. Ferran and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Biomedicine categories.
"This volume provides readers with methods and protocols for understanding the development of recombinant viruses and their use as vaccines platforms. Recombinant Virus Vaccines: Methods and Protocols details the use of recombinant vaccines that are employed to either produce immunogens in vitro or elicit antibody production in vivo. The chapters in this book are divided into four parts: Part I explores double-stranded DNA viruses; Part II discusses negative sense single-stranded RNA viruses; Part III talks about positive sense single-stranded RNA viruses; and Part IV describes bacteriophages. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Recombinant Virus Vaccines: Methods and Protocols is a valuable resource for scientists and clinicians who are interested in learning about and adopting methods for use in basic and biomedical research directed toward generating and developing recombinant viral vaccines."--Prové de l'editor.
Generation Of Recombinant Capripoxvirus Vaccines
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Author : Mahder Teffera
language : en
Publisher:
Release Date : 2020
Generation Of Recombinant Capripoxvirus Vaccines written by Mahder Teffera and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Capripoxvirus (CAPV) represents a genus of the poxviridae family which includes: sheep pox virus (SPPV), goat pox virus (GTPV), and lumpy skin disease virus (LSDV) affecting sheep, goats, and cattle respectively. Peste des petits ruminants (PPR) is a viral disease of ruminants caused by the morbillivirus, peste des petits ruminants virus (PPRV). These World Organization of Animal Health notifiable diseases continue to infect animals causing morbidity and mortality leading to direct and indirect economic losses in endemic countries. Currently, vaccination using live attenuated vaccines is used to control these diseases. Due to the concurrent prevalence of CAPV and PPR, the use of a bivalent vaccine would be a cost effective approach to control the diseases in sheep and goats. A live attenuated CAPV vaccine was genetically modified to express an antigenic protein from PPR. This was done using the Romanian CAPV vaccine and inserting the hemagglutinin (H) protein of PPR (Moroccan) in the IL-10 homologue gene region. This project offers a solution for the eradication of PPR as provides a thermostable vaccine which can be used instead of live attenuated PPR vaccines which are thermos-labile. Additionally, it provides a cost effective method to control CAPV diseases and PPR. The second project deals with differentiating infected from vaccinated animal vaccines (DIVA). Due to the complete immune response generated by immunized animals to conventional vaccines, it is not possible to use existing serological tests to identify whether an animal has been vaccinated or infected. Two live attenuated CAPV vaccines were utilized to generate these vaccines by attempting to knock out what was believed to be a non-essential gene. These attempts to knock out the CP25 gene of both LSDV and SPPV were not successful. It was determined that the CP25 protein is likely essential for virus replication. This project is important since it would provide an improved solution to respond to CAPV outbreaks in endemic and non-endemic countries. The current spread of LSDV throughout Europe and previous reported outbreaks of SPPV, GTPV, and LSDV in many countries highlights the need for a DIVA vaccine to improve the control of CAPV diseases.
Gene Therapy For Cancer
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Author : Kelly K. Hunt
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-26
Gene Therapy For Cancer written by Kelly K. Hunt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-26 with Medical categories.
The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.