Genes Environment And Alzheimer S Disease
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Genes Environment And Alzheimer S Disease
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Author : Orly Lazarov
language : en
Publisher: Academic Press
Release Date : 2016-02-25
Genes Environment And Alzheimer S Disease written by Orly Lazarov and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-25 with Medical categories.
Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer’s disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer’s disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists
Behavior Genetics Of Cognition Across The Lifespan
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Author : Deborah Finkel
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-07-09
Behavior Genetics Of Cognition Across The Lifespan written by Deborah Finkel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-09 with Psychology categories.
Along with psychopathology, cognition has been one of the primary phenotypic focal points of the field of behavior genetics since its inception. Francis Galton’s 1874 examination of eminent families in Britain was among the earliest attempts to investigate whether cognitive achievements run in families. This volume presents current methodologies for understanding cognitive abilities that move beyond the outdated nature vs. nurture paradigm. Recent advances in both collection and statistical modeling of twin data, particularly longitudinal twin data, make this an especially advantageous moment to produce a work that presents a collection of the groundbreaking research on cognitive abilities across the lifespan. This volume presents an overview of the current state of quantitative and molecular genetic investigations into the many facets of cognitive performance and functioning across the lifespan.
Aging
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Author : Cindy S. Bergeman
language : en
Publisher: SAGE Publications
Release Date : 1997-04-30
Aging written by Cindy S. Bergeman and has been published by SAGE Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-04-30 with Psychology categories.
Why do people age differently? Research in the field of gerontology has indicated that there are large individual differences in personality, cognitive functioning, physical health, and psychological well-being, as well as in the quality of life in the later years. It is this variability and the reasons why people age differently that this book explores. Thoughtfully written, Aging presents an overview of what is known about genetic and environmental influences on aging. Beginning with an overview of family, adoption, and twin designs, author Cindy S. Bergeman examines such topics as the research in the area of longevity and health, cognitive functioning, personality, and psychopathology; and social support, life events, and measures of the family environment. The book concludes with a summary of the field of gerontological behavioral genetics. This book will stimulate discussion and future work about the origins of individual differences in later life and will be invaluable to professionals and practitioners in the fields of developmental psychology, psychology, aging, family studies, and nursing.
Challenging Genetic Determinism
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Author : Royal Society of Canada. Symposium
language : en
Publisher: McGill-Queen's Press - MQUP
Release Date : 2011
Challenging Genetic Determinism written by Royal Society of Canada. Symposium and has been published by McGill-Queen's Press - MQUP this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
Compelling essays on understanding the interplay of genes in society.
Environmental Causes And Prevention Measures For Alzheimer S Disease
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Author : George J. Brewer
language : en
Publisher: Academic Press
Release Date : 2017-09-26
Environmental Causes And Prevention Measures For Alzheimer S Disease written by George J. Brewer and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-26 with Medical categories.
Environmental Causes and Prevention Measures for Alzheimer’s Disease examines the increased incidence of the disease in developed countries and aims to educate neuroscientists, medical practitioners and other educated individuals on new insights into environmental causation, primarily metals. This book looks into the web of evidence around the hypothesis of copper toxicity and the additional role that a high fat diet plays in disease progression and cognition loss. The data and its implications are discussed, along with potential prevention measures. This book will generate excitement and interest among neuroscientists, medical practitioners and other biomedical researchers. Emphasizes the history and epidemiology of Alzheimer’s disease, highlighting its epidemic proportions in developed countries Discusses data on new environmental factors in developed countries Provides prevention measures to potentially reduce Alzheimer’s rates through diet
Genetic Analysis Of Complex Disease
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Author : Jonathan L. Haines
language : en
Publisher: Wiley-Liss
Release Date : 2006-05-05
Genetic Analysis Of Complex Disease written by Jonathan L. Haines and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-05 with Medical categories.
Provides a comprehensive introduction to the various strategies, designs, and methods of analysis for the study of human genetic disease. It offers a broad-based understanding of the problems and solutions based on successful applications in the design and execution of gene mapping projects. Chapters present clear and easily referenced overviews of the broad range of considerations involved in genetic analysis of human genetic disease, including design, sampling, data collection, linkage and association studies, and social, legal, and ethical issues. Incorporating all new discussion questions and practical examples within each chapter, the book significantly updates treatment of bioinformatics, multiple comparisons, sample size requirements, parametric linkage analysis, case-control and family based approaches, and genomic screening. It covers new methods for analysis of gene-gene and gene-environmental interactions, and features a complete rewrite of the chapter on determining genetic components of disease.
Neurodegeneration From Genetics To Molecules
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Author : Victoria Campos-Peña
language : en
Publisher: Frontiers Media SA
Release Date : 2016-11-15
Neurodegeneration From Genetics To Molecules written by Victoria Campos-Peña and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-15 with Electronic book categories.
Chronic degenerative diseases are one of the major public health problems, particularly those affecting the nervous system. They are characterized by the degeneration of specific cell populations that include several pathologies which contribute significantly to morbidity and mortality in the elderly population. Therefore, in recent years, the study of neuroscience has gained significant importance. Most of these neurodegenerative disorders are the result of a complex interaction between genetic and environmental factors that generate progression and can even determine its severity. The presence of mutations in genes as LRRK2, SNCA, PARK7, PARK2 or PINK1 is associated with Parkinson's disease. Mutations in genes such as APP, PS1 and PS2 are associated with familial Alzheimer's disease; while HTT gene mutations are the cause of Huntington's disease. In most cases, this condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. It is known that these mutations can also alter the proteins function; however, it has not yet been possible to fully understand how some genetic changes cause the disease or influence the risk of developing these disorders. Most symptoms seen in these conditions occurs when specific nerve cells are damaged or die generating a loss in brain communication. Also many of these mutations generate aggregation of intracellular or extracellular proteins affecting cell function and eventually causing neuronal death. It is unclear whether the presence of these aggregates play an important role in nerve cell death during the development of neurodegenerative diseases, or if they are simply part of the response of cells to the disease. Other mutations affect the mitochondrial function generating alterations in energy production and promoting the formation of unstable molecules such as free radicals. Under normal conditions, the harmful effects caused by free radicals, are offset within the cell. However, in pathological conditions, the presence of mutations can alter this process by allowing the accumulation of radicals and damaging or killing cells. On the other hand, we also know that these diseases may not have a direct genetic component, thus, the study of sporadic type neurodegenerative diseases is much more complex. Histopathological lesions as well as the cellular and molecular alterations are generally indistinguishable from familial cases. For this reason, it is important to understand the genetic and molecular mechanisms associated with this type of pathologies. In this sense, this issue aims to understand the molecular processes that occur in the brain, and how these are influenced by the environment, genetics and behavior.
Genetics And Mental Illness
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Author : L.L. Hall
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Genetics And Mental Illness written by L.L. Hall and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
''Refreshing and informative....describe[s] the new complex research tools, directions and interpretations in a lucid and understandable fashion.'' --- Lancet, North American edition ''Beautifully crafted...The most significant contribution of this book involves its integration of areas that are not typically considered in genetic overviews.'' --- American Scientist, 1998 ''This book does an extraordinary job of making sense out of the many complex and controversial issues surrounding psychiatric genetics...It is worth the price.'' --- Journal of Genetic Counseling, Vol. 6, No. 3, 1997 This collection of essays clearly examines the complex nature of mental illness, focusing on the theory and state of the art of psychiatric genetics. This insightful volume is the first to present the diverse viewpoints of investigators, policy analysts, and psychiatric patients. Contributors explore the roles of genes in mental illness and describe various clinical, ethical, and social implications of psychiatric genetics. Additional discussions include trends in psychiatric genetic research, nature versus nurture in behavioral genetics, basic statistical principles of linkage analysis, and the many social domains relevant to psychiatric genetics.
Genetic Disorders
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Author : Robin Santos Doak
language : en
Publisher: Benchmark Education Company
Release Date : 2011
Genetic Disorders written by Robin Santos Doak and has been published by Benchmark Education Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Genetic disorders categories.
Readers learn about different types of genetic disorders. They learn how some are passed down from parent to child while others happen when the environment affects genes.
How Our Brain Became Human
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Author : Yanko A. Yankov MD PhD.
language : en
Publisher: Trafford Publishing
Release Date : 2022-10-18
How Our Brain Became Human written by Yanko A. Yankov MD PhD. and has been published by Trafford Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-18 with Science categories.
The human brain growth and evolution have been subjects of many genetic, environmental or social studies separately. Additionally, there are very few available sources on the complex role of our microbiome and the recently discovered hormones VIP and PACAP. The book author also describes some of his cases seen during his long clinical experience to illustrate different points of his extensive literature review. The book is divided into seven chapters, condensing the author’s scientific opinion on the growth and evolution of the human brain, the organ that differentiates us from all other species. He does not dismiss any other opinions or beliefs. The author challenges scientists and clinicians to continue researching the brain without prejudice. At the end he gives his opinion on how our BIG brains can help us live better together.