Genetics And Epigenetics Of Psychiatric Diseases 2nd Edition
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Epigenetics In Psychiatry
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Author : Jacob Peedicayil
language : en
Publisher: Academic Press
Release Date : 2021-08-21
Epigenetics In Psychiatry written by Jacob Peedicayil and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-21 with Science categories.
Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field
Neuropsychiatric Disorders And Epigenetics
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Author : Jacob Peedicayil
language : en
Publisher: Academic Press
Release Date : 2023-09-28
Neuropsychiatric Disorders And Epigenetics written by Jacob Peedicayil and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-28 with Science categories.
Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions when the effects of environmental stimuli on epigenetic states is particularly relevant to disease. This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy.
Genetics And Epigenetics Of Psychiatric Diseases Volume Ii
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Author : Cunyou Zhao
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-16
Genetics And Epigenetics Of Psychiatric Diseases Volume Ii written by Cunyou Zhao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-16 with Science categories.
Epigenetics And Psychiatric Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-06-22
Epigenetics And Psychiatric Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-22 with Science categories.
Epigenetics and Psychiatric Disease, Volume 157, the latest volume in the Progress in Molecular Biology and Translational Science series, includes recent developments on a variety of topics, including the Epigenetic landscapes of the adversity-exposed brain, Chromosomal conformations and epigenomic regulation in schizophrenia, Progress in the epigenetics of depression, the epigenetics of circadian rhythms in imprinted neurodevelopmental disorders, DNA methylation mediating substance abuse, mechanisms and therapeutic opportunities, DNA methylation in animals model of psychosis, Epigenetics of early life stress, Epigenetic drugs for mood disorders, and more. Accessible to students and researchers alike, with content that appeals to a variety of readers Written by leading authorities in their respective fields of molecular biology
Genetics And Epigenetics Of Psychiatric Diseases 2nd Edition
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Author : Cunyou Zhao
language : en
Publisher: Frontiers Media SA
Release Date : 2020-10-09
Genetics And Epigenetics Of Psychiatric Diseases 2nd Edition written by Cunyou Zhao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-09 with Science categories.
Psychiatric diseases have a highly complex etiology, aggregating in families but not segregating in a traditional Mendelian manner. Recent approaches to understanding the causes of psychiatric disease have focused on describing the genetic contribution to major psychiatric illnesses; the use of large-scale genome-wide association studies (GWAS) and exome sequencing has enabled a systematic exploration of genetic risk factors and identified over 100 independent genomic loci significantly associated with psychiatric diseases; however, there remains uncertainty about the causal genes involved in disease pathogenesis, and how their function is regulated. Since many GWAS variants reside in non-coding regions, the disease-associated common variants might be enriched in regulatory domains, including enhancers and regions of active chromatin state. These lead us to focus on the possible role of non-sequence-based genomic variation in health and disease. Of particular interest are epigenetic modifications that regulate gene expression through modifications to DNA, RNA, histone proteins, and chromatin. The availability of high-throughput profiling methods for quantifiying epigenomic modifications in large numbers of samples has enabled us to perform epigenome-wide association studies (EWAS) aimed at screening methylomic variations associated with environmental exposure and disease. Thus systematic integration of genetic, epigenetic and epidemiological approaches will contribute to improving our understanding of the molecular mechanisms underlying disease phenotypes.
Principles Of Psychiatric Genetics
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Author : John I. Nurnberger
language : en
Publisher: Cambridge University Press
Release Date : 2012-09-13
Principles Of Psychiatric Genetics written by John I. Nurnberger and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-13 with Medical categories.
A comprehensive, up-to-date resource providing information about genetic influences on disorders of behavior.
Epigenetics
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Author : C. David Allis
language : en
Publisher: CSHL Press
Release Date : 2007
Epigenetics written by C. David Allis and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Epigenesis, Genetic categories.
The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.
Epigenetics Of Stress And Stress Disorders
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Author : Nagy Youssef
language : en
Publisher: Academic Press
Release Date : 2022-02-18
Epigenetics Of Stress And Stress Disorders written by Nagy Youssef and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-18 with Medical categories.
Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through the evaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stress disorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understanding stress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range of recent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developments in noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods or development and across the life span. The book concludes by looking at possible transgenerational stress-induced epigenetic alterations on future offspring and important areas of research for public health, along with the potential for epigenetic therapeutics or “epidrugs. Examines the epigenetics of stress, trauma, and related stress disorders Connects new research to clinical practice and highlights implications for patient care, drug discovery, and public health Discusses the epigenetic effect of adversity across the life span, and transgenerational stress-induced epigenetic alterations Features chapter contributions from international experts in the field
The International Handbook On Psychopathic Disorders And The Law
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Author : Alan Felthous
language : en
Publisher: John Wiley & Sons
Release Date : 2008-03-10
The International Handbook On Psychopathic Disorders And The Law written by Alan Felthous and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-10 with Psychology categories.
The economic impact of society’s efforts to rehabilitate and contain psychopathically disordered individuals can be enormous. Understanding these disorders, developing valid assessment methods and providing safe, effective treatments is therefore of paramount importance. Reflecting the work of a truly international panel of experts from Europe, North America and Asia, the International Handbook on Psychopathic Disorders and the Law offers an in-depth, multidisciplinary look at key aspects of the development and etiology of psychopathic disorders, current methods of intervention, treatment and management, and how these disorders impact decision-making in civil and criminal law.
Affective And Schizoaffective Disorders
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Author : Andreas Marneros
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Affective And Schizoaffective Disorders written by Andreas Marneros and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Several contributions in our first book about schizo affective disorders (Marneros and Tsuang, Schizoaffective Psychoses, Springer-Verlag, 1986) supported the assumption that schizoaffective disorders differ in relevant ways from schizophrenic disorders. The classification of schizo affective disorders as a subgroup of schizophrenia has also been criticized, and empirical research in clinical, genetic, therapeutic, and prognostic areas supports the idea that there are some strong similari ties between schizo affective and affective disorders. Of course, there are not only similarities between these two groups, but also differences just as there are between schizo affective and schizophrenic disorders. It is precisely the existence of similarities and differences between schizo affective disorders and the other two so-called typical mental disorders, i.e., schizophrenia and affective disorders, which makes them a challenge in psychiatric research, a challenge to the traditional dichotomy in the classification of disorders which originated with Kraepelin. This challenge is certainly proving fruitful in psychiatric research. These "cases in between" may well demonstrate that sep arating, dividing, and limiting is not always meaningful. Sometimes it can be more meaningful to unify; to unify in the sense of building bridges between typical groups. It is here that the assumption of a "psychotic continuum" can become relevant, and the investigation of schizoaffective disorders is of prime importance in research on a possible continuum of psychosis.