Neuropsychiatric Disorders And Epigenetics
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Neuropsychiatric Disorders And Epigenetics
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Author : Jacob Peedicayil
language : en
Publisher: Elsevier
Release Date : 2023-09-29
Neuropsychiatric Disorders And Epigenetics written by Jacob Peedicayil and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-29 with Science categories.
Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant to disease. This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy. By helping to define epigenetics as a key player in neuropsychiatric disorders, this volume empowers new research, clinical translation, and pharmacological advances, and highlights promising directions for ongoing investigation. Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists Features extensive use of diagrams, illustrations, tables, and graphical abstracts for each section to reinforce understanding Includes chapter contributions from leading global experts
Novel Approaches To Studying Basal Ganglia And Related Neuropsychiatric Disorders
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Author : XIAO-HONG LU
language : en
Publisher: Academic Press
Release Date : 2009-11-06
Novel Approaches To Studying Basal Ganglia And Related Neuropsychiatric Disorders written by XIAO-HONG LU and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-06 with Science categories.
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of articles covering Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders. Topics covered include molecular profiling of direct and indirect striatal medium spiny neurons, the role of epigenetics in development and function of basal ganglia and transgenic animal models for Parkinson's disease.
Epigenetic Mechanisms In Development And Disease
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Author : Paul J. Hurd
language : en
Publisher:
Release Date : 2013
Epigenetic Mechanisms In Development And Disease written by Paul J. Hurd and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Cell differentiation categories.
Epigenetic Mechanisms in Development and Disease, the latest volume in the Biochemical Society Symposia series, features ten chapters from the Biochemical Society's Annual Symposium held at the University of Leeds on 11 - 13 December 2012. Epigenetic mechanisms, including the post translational modifications of chromatin (DNA and histones), play pivotal roles in development, cell differentiation and cell identity. Inappropriate regulation of epigenetic mechanisms has been implicated in common human diseases including diabetes, neuropsychiatric disorders and cancers. Environmental influences such as nutrition and stress can lead to epigenetic alterations and contribute to chronic disease biology.
Pharmacoepigenetics
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Author : Ramón Cacabelos
language : en
Publisher: Elsevier
Release Date : 2024-09-01
Pharmacoepigenetics written by Ramón Cacabelos and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-01 with Science categories.
Pharmacoepigenetics, Second Edition, a volume within the Translational Epigenetics series, is a comprehensive reference on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible view of the field, from basic principles to applications in disease therapeutics. Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine.The new edition has been fully revised to address recent advances in epigenetics, from new natural and synthetic compounds with epigenetic effects to the role of epigenetics in the pathogenesis of a growing number of complex diseases, including further cancers, cardiovascular disorders, and brain disorders. Newly identified molecular components in the functional architecture of the epigenetic machinery, as well as practical and relevant pharmacoepigenetics topics related to COVID-19 and other world health challenges, are also discussed. Each chapter has been updated to include a chapter summary, keywords and definitions, and further color figure and charts for learning reinforcement, along with clinical research case studies illustrating key research in the field and making findings and research approaches more actionable for readers. Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development Features chapter contributions from leading international researchers in academia, clinical settings, and the pharmaceutical industry Instructs researchers, students, and clinicians in better interpreting and employing pharmacoepigenetics in drug development, efficiency, and safety Incorporates recent advances, including epigenetic drugs and biomolecules with epigenetic effects in cancer, cardiovascular disorders, brain disorders, and COVID-19 Includes chapter definitions, key words, and summaries to reinforce understanding, as well clinical research case studies illustrating key research in the field
Epigenetics In Psychiatry
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Author : Jacob Peedicayil
language : en
Publisher: Academic Press
Release Date : 2021-08-21
Epigenetics In Psychiatry written by Jacob Peedicayil and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-21 with Science categories.
Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field
Neuropsychiatric Disorders
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Author : Koho Miyoshi
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-08-09
Neuropsychiatric Disorders written by Koho Miyoshi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-09 with Medical categories.
Around the world societies are facing growing aging populations with the concomitant increase in neuropsychiatric disorders. Neuropsychiatric disorders are organic brain diseases with psychiatric symptoms, as in Alzheimer’s and Parkinson’s diseases, that cause cognitive impairment, including dementia, amnesic syndrome, and personality–behavioral changes. As a clinical science, neuropsychiatry aims to explore the complex interrelationship between behavior and brain function from a variety of perspectives, including those of psychology, neurology, and psychiatry. This concise and updated monograph comprises the latest findings in the field and includes chapters on delusional symptoms, mood disorders and neurotic symptoms, cognitive impairment, behavioral and personality changes, and recently, cerebral alterations revealed in PTSD patients and in endogenous psychoses through neuroimaging and neuropathology. These findings will certainly widen the realm of neuropsychiatry going forward and will prove of great value to specialists as well as to academics and trainees in neurology, psychiatry, neuropsychology, neuroradiology, neuropathology, neurophysiology, neurochemistry, and clinical genetics. Ultimately, neuropsychiatry aims to prevent and reduce the suffering of individuals with the psychiatric symptoms of cerebral disorders.
Staging Neuropsychiatric Disorders
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Author : Tomás Palomo
language : en
Publisher: Springer
Release Date : 2013-07-09
Staging Neuropsychiatric Disorders written by Tomás Palomo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-09 with Medical categories.
Book chapters are authored by participants in the International Meeting on Staging Neuropsychiatric Disorders: Implications for Etiopathogenesis and Treatment, held in Mojácar (Almería) Spain from 14-18 October 2009. Chapters are organized into four sections on themes encompassed by Staging Neuropsychiatric Disorders: Clinical Staging in the Pathophysiology of Psychotic and Affective Disorders, Staging Perspectives in Neurodevelopmental Aspects of Neuropsychiatry, Epigenetics and Biomarkers in the Staging of Neuropsychiatric Disorders, and Staging Neurodegenerative Disorders. This volume should serve as a resource for physicians and neuroscientists alike, highlighting the importance of staging neuropsychiatric disorders and the underlying mechanistic dysfunction, for prevention and treatment strategies at different stages of disease progression. Earlier volumes in the series, published by the Fundación Cerebro y Mente in Madrid, Spain: Depressive, Anxiety and Drug Abuse Disorders Eds: T. Palomo and T. Archer Schizophrenia, Movement Disorders and Age Related Cognitive Disorders Eds.: T. Palomo, T. Archer and R.J. Beninger Dopamine Disease States Eds.: R.J. Beninger, T. Palomo and T. Archer Interactive Monoaminergic Disorders Eds.: T. Palomo, R.J. Beninger and T. Archer Neurodegenerative Brain Disorders Eds.: T. Palomo, R.J. Beninger and T. Archer Neurodevelopmental Liabilities in Brain Disease States Eds.: R.J. Beninger, T. Palomo, R.M. Kostrzewa and T. Archer Gene-Environment Interplay in Brain Disease States Eds.: T. Palomo, R.J. Beninger, R.M. Kostrzewa and T. Archer Implications of CoMorbidity for Etiology and Treatment of Neuropsychiatric Disorders Eds.: T. Palomo, R.J. Beninger, R.M. Kostrzewa and T. Archer Beyond Neuropsychiatric Diagnostics: Symptoms not Disorders Eds.: T. Palomo, R.J. Beninger, R.M. Kostrzewa and T. Archer
Epigenetics Of Stress And Stress Disorders
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Author : Nagy Youssef
language : en
Publisher: Academic Press
Release Date : 2022-02-18
Epigenetics Of Stress And Stress Disorders written by Nagy Youssef and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-18 with Medical categories.
Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through the evaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stress disorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understanding stress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range of recent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developments in noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods or development and across the life span. The book concludes by looking at possible transgenerational stress-induced epigenetic alterations on future offspring and important areas of research for public health, along with the potential for epigenetic therapeutics or “epidrugs. Examines the epigenetics of stress, trauma, and related stress disorders Connects new research to clinical practice and highlights implications for patient care, drug discovery, and public health Discusses the epigenetic effect of adversity across the life span, and transgenerational stress-induced epigenetic alterations Features chapter contributions from international experts in the field
Epigenetic Regulation In The Nervous System
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Author : J. David Sweatt
language : en
Publisher: Academic Press
Release Date : 2012-12-31
Epigenetic Regulation In The Nervous System written by J. David Sweatt and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.
Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics
Principles Of Psychiatric Genetics
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Author : John I. Nurnberger
language : en
Publisher: Cambridge University Press
Release Date : 2012-09-13
Principles Of Psychiatric Genetics written by John I. Nurnberger and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-13 with Medical categories.
A comprehensive, up-to-date resource providing information about genetic influences on disorders of behavior.