Genome Plasticity In Health And Disease
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Genome Plasticity In Health And Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-04-08
Genome Plasticity In Health And Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-08 with Medical categories.
Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery
Cellular Endocrinology In Health And Disease
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Author : Alfredo Ulloa-Aguirre
language : en
Publisher: Academic Press
Release Date : 2021-02-02
Cellular Endocrinology In Health And Disease written by Alfredo Ulloa-Aguirre and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-02 with Science categories.
Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field
Human Retrotransposons In Health And Disease
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Author : Gael Cristofari
language : en
Publisher: Springer
Release Date : 2018-07-07
Human Retrotransposons In Health And Disease written by Gael Cristofari and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-07 with Medical categories.
This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging.
Developmental Origins Of Health And Disease
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Author : Peter Gluckman
language : en
Publisher: Cambridge University Press
Release Date : 2006-04-20
Developmental Origins Of Health And Disease written by Peter Gluckman and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-20 with Medical categories.
This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.
Tandem Repeat Polymorphisms
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Author : Anthony J. Hannan
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-07-30
Tandem Repeat Polymorphisms written by Anthony J. Hannan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-30 with Medical categories.
This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease. There are hundreds of thousands of unique tandem repeats in the human genome and their polymorphic distributions have the potential to greatly influence functional diversity and disease susceptibility. Recent discoveries in this expanding field are critically reviewed and discussed in a range of subsequent chapters, with a focus on the role of TRPs and their various gene products in evolution, development, diverse molecular and cellular processes, brain function and disease.
Dna Methylation And Complex Human Disease
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Author : Michel Neidhart
language : en
Publisher: Academic Press
Release Date : 2015-08-11
Dna Methylation And Complex Human Disease written by Michel Neidhart and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-11 with Science categories.
DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases
Renaissance Of Sickle Cell Disease Research In The Genome Era
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Author : Betty S Pace
language : en
Publisher: World Scientific
Release Date : 2007-01-24
Renaissance Of Sickle Cell Disease Research In The Genome Era written by Betty S Pace and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-24 with Medical categories.
The Human Genome Project has spawned a Renaissance of research faced with the daunting expectation of personalized medicine for individuals with sickle cell disease in the Genome Era. This book offers a comprehensive and timeless account of emerging concepts in clinical and basic science research, and community concerns of health disparity to educate professionals, students and the general public about meeting this challenging expectation. Contributions from physicians, research scientists, scientific administrators and community workers make Renaissance of Sickle Cell Disease Research in the Genome Era unique among the catalogue of books on this genetic disorder. Part 1 offers detailed review of the National Heart Lung and Blood Institute's leadership role in funding sickle cell research, as well as developing progressive research initiatives and the predicted impact of the Human Genome Project. Part 2 gives an account of several clinical research perspectives based on the Cooperative Study of Sickle Cell Disease. These include recommendations for newborn screening, pain management, stroke, transfusion therapy and pediatric and adult healthcare. Part 3 offers novel insights into basic science research progress and the impact of the Human Genome Project on the direction of hemoglobinopathy research, including hemoglobin switching, bone marrow transplantation and gene therapy. Part 4 engages the reader in a culture-based discussion of the stigma attached to sickle cell disease in the African American community and the apprehensions about genetic research in this community. It concludes with a global perspective on sickle cell disease from African, European and American experiences. For readers seeking a definitive account of sickle cell disease appropriate for students, researchers and community workers, this collaborative effort is an ideal textbook. Contents:Sickle Cell Disease: Demystifying the Beginnings (C Reid & G Rodgers)Sponsorship of Sickle Cell Disease Research by the National Institutes of Health: A Brief History and Projections for the Future (G L Evans & D G Badman)The Human Genome Project (B S Pace)Sickle Cell Disease: A Phenotypic Patchwork (K Smith-Whitley & B S Pace)Preventive Care and Advances in the Treatment of Sickle Cell Disease (C T Quinn & G R Buchanan)Sickle Cell Disease in Adults (J Haynes, Jr. & A Pack-Mabien)Pain in Sickle Cell Disease: A Multidimensional Construct (L J Benjamin & R Payne)Transfusion Therapy in Sickle Cell Disease (C Hoppe et al.)Hemoglobin S Polymerization, Just the Beginning (F A Ferrone)Damage to the Red Blood Cell Membrane in Sickle Cell Disease (S R Goodman & C Joiner)Fetal Hemoglobin for What Ails Sickle Hemoglobin (S F Ofori-Acquah & B S Pace)Genetic Modulation of Sickle Cell Disease (M H Steinberg & L T Swee)Molecular Framework of Hemoglobin Switching (S Fiering)Dynamic Nucleoprotein Structure of the ß-Globin Locus: Establishing a Rational Molecular Basis for the Therapeutic Modulation of Hemoglobin Switching (E Bresnick et al.)Vertebrate Models for Sickle Cell Disease Research (B H Paw et al.)Stem Cell Biology (W Li & A W Flake)Bone Marrow Transplantation (R I Raphael & M C Walters)Genetically Engineered Cures: Gene Therapy for Sickle Cell Disease (P Malik & P Leboulch)Sickle Cell Disease: The Past, Present and Future Social and Ethical Dilemmas (V L Bonham, Jr. et al.)It Takes a Village to Cure Sickle Cell Disease (R Peterson & D Davis-Maye)Beyond National Borders: A Global Perspective on Advances in Sickle Cell Disease Research and Management, and New Challenges in the Genome Era (S F Ofori-Acquah & K Ohene-Frempong) Readership: Primary market: Clinical and basic researchers in haematology and genetics, graduate students and postdoctoral fellows; Secondary market: Nursing students, community sickle cell programs, medical school libraries, public library; Tertiary market: Suitable for a graduate course in genetics, genomics as a supplemental text, probably not a primary text. Keywords:Sickle Cell Anemia/Disease;Genomic Era;National Heart Lung and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;Stroke;Pain Management;Fetal Hemoglobin;Hemoglobin Switching;Transgenic Mouse Model;Locus Control Region;African-American Community;Sickle Cell Africa;World Health OrganizationKey Features:Covers the latest progress made in clinical, basic and social research of SCDCaptures the momentum of research efforts related to SCD; this is very timely in light of the plan to perform the first gene therapy treatment in 2006Five out of ten of the current Directors of the National Heart, Lung, and Blood Institute (NHLBI)-funded Comprehensive Sickle Cell Centers are amongst the prominent contributors to the book. These clinical and basic researchers have a major influence in shaping the future focus of programs for sickle cell disease in the United States
Healthy Lifestyle
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Author : Roya Kelishadi
language : en
Publisher: Springer Nature
Release Date : 2022-01-01
Healthy Lifestyle written by Roya Kelishadi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-01 with Science categories.
This book offers a comprehensive overview on lifestyle habits related to development of risk factors of chronic diseases. It provides a summary of the impacts of various modifiable factors that influence long-term health status. The accumulation of unhealthy lifestyle habits shows that over the life course, increasing the number, duration, and severity of unhealthy behaviors would increase the risk of disease development. This contributed volume highlights the fact that establishing a healthy lifestyle is easier and more effective than focusing on lifestyle change
Investigating The Human Genome
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Author : Moyra Smith
language : en
Publisher: FT Press
Release Date : 2011-06-08
Investigating The Human Genome written by Moyra Smith and has been published by FT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-08 with Medical categories.
Leading medical genetics scholar Moyra Smith reviews current and recent work in genetics and genomics to assess progress in understanding human variation and the pathogenesis of common and rare diseases in which genetics plays a role. Smith provides an exceptional overview of the most important biomedical progress arising from the greatly increased genetic information base generated by gene mapping and the sequencing of the complete Human Genome. This book addresses into a wide spectrum of topics associated with human genetics and genomics, including: Human origins; migrations and human population diversity gained though genomic analyses. The complexities of psychiatric diseases that are influenced by genetics. The pathogenesis of late-onset neurological diseases such as Alzheimer’s, Parkinsonism, and ALS. Key aspects of protein misfolding. Gene-environment interactions in DNA damage and repair and DNA instability. Micro RNAs and mRNA translation. Epigenetics. New functions for old enzymes in cancer.
New Horizons In Health
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2001-03-09
New Horizons In Health written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-03-09 with Social Science categories.
New Horizons in Health discusses how the National Institutes of Health (NIH) can integrate research in the social, behavioral, and biomedical sciences to better understand the causes of disease as well as interventions that promote health. It outlines a set of research priorities for consideration by the Office of Behavioral and Social Sciences Research (OBSSR), with particular attention to research that can support and complement the work of the National Institutes of Health. By addressing the range of interactions among social settings, behavioral patterns, and important health concerns, it highlights areas of scientific opportunity where significant investment is most likely to improve nationalâ€"and globalâ€"health outcomes. These opportunities will apply the knowledge and methods of the behavioral and social sciences to contemporary health needs, and give attention to the chief health concerns of the general public.