Genetics For Rheumatologists
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Genetics For Rheumatologists
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Author : Matthew A. Brown
language : en
Publisher: Remedica
Release Date : 2002
Genetics For Rheumatologists written by Matthew A. Brown and has been published by Remedica this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Molecular genetics categories.
Annotation Trainee and practicing rheumatologists The study of disease genetics arguably began in rheumatology, with the description of the hereditary basis of alkaptonuria by Garrod in 1902, and the introduction of the concept of in-born errors of metabolism. A large proportion of the diseases seen by rheumatologists have genetic influences. The dissection of the genetic basis of rheumatic diseases has moved rapidly over the past 15 years. Increasingly, rheumatologists are being asked the question "How likely is it that my children will develop the disease I have?', and about the utility of genetic testing for those diseases. This book is not a hefty tome full of genetics jargon, but a quick reference source for doctors written to help answer those questions.
The Hereditary Basis Of Rheumatic Diseases
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Author : Rikard Holmdahl
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-07-02
The Hereditary Basis Of Rheumatic Diseases written by Rikard Holmdahl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-02 with Medical categories.
Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part deals with the shared heredity of rheumatic diseases, e.g., RA, lupus and ankylosing spondylitis. The third part of the volume describes tools for analysing genetic complexity, ranging from animal models to new molecular tools. The volume is essential reading for researchers and clinicians from rheumatology, inflammation research, immunology, and cell and molecular biology.
The Hereditary Basis Of Rheumatic Diseases
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Author : Rikard Holmdahl
language : en
Publisher: Birkhäuser
Release Date : 2009-09-03
The Hereditary Basis Of Rheumatic Diseases written by Rikard Holmdahl and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-03 with Medical categories.
Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part deals with the shared heredity of rheumatic diseases, e.g., RA, lupus and ankylosing spondylitis. The third part of the volume describes tools for analysing genetic complexity, ranging from animal models to new molecular tools. The volume is essential reading for researchers and clinicians from rheumatology, inflammation research, immunology, and cell and molecular biology.
Genetics Of Rare Autoimmune Diseases
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Author : Javier Martín
language : en
Publisher: Springer
Release Date : 2019-05-29
Genetics Of Rare Autoimmune Diseases written by Javier Martín and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-29 with Medical categories.
The main aim of this volume is to provide an updated overview of the genetic basis of a group of complex disorders that are considered rare individually, but show a relatively high prevalence on the whole in developed countries: the rare autoimmune diseases. These are chronic disorders that involve long and expensive treatments with considerable side effects that may dramatically reduce the quality of life of affected people. Therefore, shedding light into their pathologic mechanisms is a major concern given their growing social and economic awareness and impact. General sections include different chapters on single entities as systemic lupus and sclerosis, Behçet’s disease, Sjogren’s syndrome and polymiositis, and sections devoted to autoimmune vasculitis, hepatic autoimmune conditions, as well as those affecting the nervous system, and a concluding chapter in which the shared predisposition amongst all diseases is discussed. All the chapters are given a homogeneous scheme in which the authors explain the clinical singularities of every disease and report the recent breakthrough discoveries related to them, giving a critical interpretation and suggesting future perspectives. All contributors are renowned researchers with high expertise in each disease. Due to the exponential increase in our understanding of the genetic causes of these complex diseases, a major advance in biomedical discovery is taking place. However, most of the achievements in this field are very recent and there is a lack of bibliography gathering them together. This book is thus filling a gap and will prove a useful companion to clinicians in the first place (internists, rheumatologists, clinical immunologists, and hematologists) but also to basic and applied researchers.
Genomics In Rheumatic Diseases An Issue Of Rheumatic Disease Clinics Of North America
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Author : S. Louis Bridges Jr.
language : en
Publisher: Elsevier Health Sciences
Release Date : 2017-08-01
Genomics In Rheumatic Diseases An Issue Of Rheumatic Disease Clinics Of North America written by S. Louis Bridges Jr. and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-01 with Medical categories.
This issue of Rheumatic Disease Clinics focuses on Genetics. Article topics cover: Genetic Influences on Susceptibility and Severity of Rheumatoid Arthritis; HLA-disease associations in rheumatoid arthritis; Autoinflammatory Syndromes as a Model of Monogenic Diseases; Genomic Influences on Hyperuricaemia and Gout; Genetics of Systemic Lupus Erythematosus; Genetics of Ankylosing Spondylitis;Genetics of Scleroderma; Genetics of Osteoarthritis; Genetics of Juvenile Inflammatory Arthritis; Genetic Influences on Treatment Response in Rheumatic Diseases; Integrative approaches/computational biology; Future directions of genetic research in rheumatic diseases; and Population genetics and natural selection in rheumatic disease.
Beh Et S Disease
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Author : Yoshiaki Ishigatsubo
language : en
Publisher: Springer
Release Date : 2014-12-03
Beh Et S Disease written by Yoshiaki Ishigatsubo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-03 with Medical categories.
This book, besides reviewing basic and clinical aspects of Behçet's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behçet's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behçet's disease. Behçet's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behçet's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.
Genes And Genetics Of Autoimmunity
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Author : A. N. Theofilopoulos
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1999
Genes And Genetics Of Autoimmunity written by A. N. Theofilopoulos and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Science categories.
Autoimmunity is one of the most highly investigated areas of immunologic research. The principle of immune system discrimination between self and foreign molecules is fundamental to the survival of the species, and the failure to establish or maintain this discrimination can lead to a wide spectrum of diseases. As a consequence of intensive studies, much has been learned with regard to the normal functioning of the immune system and the editing processes by which self-tolerance is established. Moreover, many theories and experimental models have been developed to explore the mechanisms of autoimmune disease pathogenesis. This book is the first volume of the new series 'Current Directions in Autoimmunity', which aims to consolidate current knowledge of autoimmunity focusing on both basic and clinical aspects. Given that these diseases have a strong genetic basis, it seems appropriate that the first volume addresses this topic. It reviews the most recent findings on genes affecting autoimmunity and genome-wide studies defining the multiple loci predisposing to prominent autoimmune diseases, such as lupus, arthritis, diabetes and multiple sclerosis. For each of these entities, studies in experimental models as well as humans are covered. The authoritative and timely material will be of interest to investigators in the fields of immunology and genetics, to clinicians with interest in rheumatology, endocrinology and neurology, and to those working to devise gene-specific therapies for a variety of inflammatory conditions.
Absolute Rheumatology Review
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Author : Petros Efthimiou
language : en
Publisher: Springer Nature
Release Date : 2019-09-13
Absolute Rheumatology Review written by Petros Efthimiou and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-13 with Medical categories.
This book provides a concise and up-to-date review of key rheumatology topics along with extensive practice questions to assist in preparing for the American Board of Internal Medicine (ABIM) Rheumatology Certification Exam. Each chapter focuses on a single disease and starts with a short review (primarily tables and figures) to highlight the main points and key issues. The review is followed by 10-20 board-style multiple choice questions with detailed explanations for each topic. The chapters and associated preparation questions are written by established experts from top institutions in the United States. The book concludes with a 50-question practice test reflecting the format used by the ABIM Board Certification Exam. Absolute Rheumatology Review is an essential resource for not only graduate students, residents, and fellows in rheumatology and internal medicine studying for board exams but also rheumatologists, physicians, and related professionals preparing for recertification.
Modern Therapeutics In Rheumatic Diseases
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Author : George C. Tsokos
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-11-08
Modern Therapeutics In Rheumatic Diseases written by George C. Tsokos and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-08 with Medical categories.
Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.
Rheumatoid Arthritis
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Author : Josef S. Smolen
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Rheumatoid Arthritis written by Josef S. Smolen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Many advances have occurred in the last 5 years especially in understanding genetic susceptibility factors, the role of immune response in chronic arthritis and the relationship between cellular processes that underlie inflammation and tissue damage. All these are dealt with in depth in the individual contributions. Genetics studies included illustrate how studies of HLA genes and genes controlling the autoantibody repertoire may be involved. Environmental factors are believed to be important and studies both in humans and in experimental models on the role of viral and bacterial agents are covered. The fascinating relationship between microbes, dysregulated immune responses and oncogenes are also examined. Since autoimmunity is the key aspect of the immunological response in rheumatoid arthritis, the role of antigens is re-examined as is the part played by immune T and B cells. New areas of clinical application of basic science is well presented in this book, forexample, in examining how markers of cartilage destruction may become important in monitoring disease activity. A chapter reviewing possible future novel therapies is included.